Gene description for GPC3
Gene name	glypican 3
Gene symbol	GPC3
Other names/aliases	DGSX GTR2-2 MXR7 OCI-5 SDYS SGB SGBS SGBS1
Species	Homo sapiens
Database cross references - GPC3
ExoCarta	ExoCarta_2719
Entrez Gene	2719
HGNC	4451
MIM	300037
UniProt	P51654
GPC3 identified in exosomes derived from the following tissue/cell type
Liver cancer cells	25265333

Gene ontology annotations for GPC3

Molecular Function     peptidyl-dipeptidase inhibitor activity GO:0060422 IDA     protein binding GO:0005515 IPI     heparan sulfate proteoglycan binding GO:0043395 IEA Biological Process     mesonephric duct morphogenesis GO:0072180 IEA     mesenchymal cell proliferation involved in ureteric bud development GO:0072138 ISS     chondroitin sulfate metabolic process GO:0030204 TAS     glycosaminoglycan catabolic process GO:0006027 TAS     cell proliferation involved in metanephros development GO:0072203 IEA     negative regulation of peptidase activity GO:0010466 IEA     anterior/posterior axis specification GO:0009948 IEA     body morphogenesis GO:0010171 IEA     embryonic hindlimb morphogenesis GO:0035116 IEA     lung development GO:0030324 IEA     negative regulation of epithelial cell proliferation GO:0050680 IEA     positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IEA     small molecule metabolic process GO:0044281 TAS     retinoid metabolic process GO:0001523 TAS     positive regulation of protein catabolic process GO:0045732 IEA     positive regulation of smoothened signaling pathway GO:0045880 IEA     negative regulation of growth GO:0045926 IEA     positive regulation of glucose import GO:0046326 IEA     anatomical structure morphogenesis GO:0009653 TAS     coronary vasculature development GO:0060976 IEA     glycosaminoglycan biosynthetic process GO:0006024 TAS     branching involved in ureteric bud morphogenesis GO:0001658 IEA     glycosaminoglycan metabolic process GO:0030203 TAS     negative regulation of smoothened signaling pathway GO:0045879 IEA     bone mineralization GO:0030282 IEA     osteoclast differentiation GO:0030316 IEA     positive regulation of BMP signaling pathway GO:0030513 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 IEA     carbohydrate metabolic process GO:0005975 TAS     positive regulation of endocytosis GO:0045807 IEA     phototransduction, visible light GO:0007603 TAS Subcellular Localization     Golgi lumen GO:0005796 TAS     plasma membrane GO:0005886 TAS     lysosomal lumen GO:0043202 TAS     anchored component of plasma membrane GO:0046658 IEA     proteinaceous extracellular matrix GO:0005578 IEA     integral component of plasma membrane GO:0005887 TAS     extracellular exosome GO:0070062 IDA     extracellular space GO:0005615 IEA