Gene description for ZFPL1
Gene name zinc finger protein-like 1
Gene symbol ZFPL1
Other names/aliases D11S750
MCG4
Species Homo sapiens
 Database cross references - ZFPL1
ExoCarta ExoCarta_7542
Vesiclepedia VP_7542
Entrez Gene 7542
HGNC 12868
UniProt O95159  
 ZFPL1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ZFPL1
Molecular Function
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 NAS
Biological Process
    regulation of DNA-templated transcription GO:0006355 NAS
    vesicle-mediated transport GO:0016192 IEA
Subcellular Localization
    nucleus GO:0005634 NAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 IEA
 Experiment description of studies that identified ZFPL1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ZFPL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 TMEM14B  
Two-hybrid Homo sapiens
4 SERPINB4 6318
Affinity Capture-MS Homo sapiens
5 SLC10A6  
Two-hybrid Homo sapiens
6 CHRNA4  
Affinity Capture-MS Homo sapiens
7 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FRMD3  
Two-hybrid Homo sapiens
10 BZW2 28969
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ATP12A 479
Affinity Capture-MS Homo sapiens
12 SYNE4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 LAMP2 3920
Proximity Label-MS Homo sapiens
14 STX4 6810
Two-hybrid Homo sapiens
15 MS4A3  
Two-hybrid Homo sapiens
16 AMHR2  
Affinity Capture-MS Homo sapiens
17 TMPRSS2 7113
Two-hybrid Homo sapiens
18 STX1A 6804
Two-hybrid Homo sapiens
19 FNDC9  
Two-hybrid Homo sapiens
20 SPAG9 9043
Affinity Capture-MS Homo sapiens
21 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 KLRC1  
Two-hybrid Homo sapiens
23 CD3E 916
Two-hybrid Homo sapiens
24 ATP2A3 489
Affinity Capture-MS Homo sapiens
25 PGRMC2 10424
Two-hybrid Homo sapiens
26 HIATL1 84641
Two-hybrid Homo sapiens
27 HYPM  
Affinity Capture-MS Homo sapiens
28 SSMEM1  
Two-hybrid Homo sapiens
29 MTERF3  
Two-hybrid Homo sapiens
30 TMEM106C 79022
Two-hybrid Homo sapiens
31 HDAC10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 FOXA1  
Affinity Capture-MS Homo sapiens
33 CLEC7A  
Two-hybrid Homo sapiens
34 GORAB 92344
Two-hybrid Homo sapiens
35 RELL2  
Two-hybrid Homo sapiens
36 TMEM139  
Two-hybrid Homo sapiens
37 HPN  
Affinity Capture-MS Homo sapiens
38 PBXIP1 57326
Affinity Capture-MS Homo sapiens
39 IGHG1 3500
Affinity Capture-MS Homo sapiens
40 OSBPL2 9885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 BSND  
Two-hybrid Homo sapiens
42 CD81 975
Affinity Capture-Western Homo sapiens
43 TSTD2  
Two-hybrid Homo sapiens
44 TEX29  
Two-hybrid Homo sapiens
45 RANBP6 26953
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SCN3B  
Two-hybrid Homo sapiens
47 MFF 56947
Two-hybrid Homo sapiens
48 CALML3 810
Affinity Capture-MS Homo sapiens
49 FAM170A  
Affinity Capture-MS Homo sapiens
50 SLC19A3  
Two-hybrid Homo sapiens
51 IVL 3713
Affinity Capture-MS Homo sapiens
52 CXCR4 7852
Affinity Capture-MS Homo sapiens
53 PITPNM3 83394
Affinity Capture-MS Homo sapiens
54 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
55 TM4SF19  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
56 LAMP1 3916
Co-fractionation Homo sapiens
57 OSBPL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 ERGIC3 51614
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SKP2  
Affinity Capture-MS Homo sapiens
60 NIPAL1  
Affinity Capture-MS Homo sapiens
61 FKBP8 23770
Two-hybrid Homo sapiens
62 CCDC155  
Two-hybrid Homo sapiens
63 S100A7A 338324
Affinity Capture-MS Homo sapiens
64 CREB3L1  
Two-hybrid Homo sapiens
65 A2ML1 144568
Affinity Capture-MS Homo sapiens
66 LEUTX  
Two-hybrid Homo sapiens
67 FAM209A 200232
Two-hybrid Homo sapiens
68 SAAL1 113174
Affinity Capture-MS Homo sapiens
69 ATP5J2 9551
Two-hybrid Homo sapiens
70 GPR42  
Two-hybrid Homo sapiens
71 TMEM237 65062
Two-hybrid Homo sapiens
72 Uso1 56041
Affinity Capture-MS Mus musculus
73 TSPAN1 10103
Affinity Capture-MS Homo sapiens
74 HIBADH 11112
Two-hybrid Homo sapiens
75 CPLX4  
Two-hybrid Homo sapiens
76 SLC22A15  
Affinity Capture-MS Homo sapiens
77 LIME1 54923
Two-hybrid Homo sapiens
78 AHNAK2 113146
Two-hybrid Homo sapiens
79 FATE1  
Two-hybrid Homo sapiens
80 ACBD5 91452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 LCN2 3934
Affinity Capture-MS Homo sapiens
82 STX2 2054
Two-hybrid Homo sapiens
83 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 SMIM3  
Two-hybrid Homo sapiens
85 PPP2R5E 5529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 MIP  
Two-hybrid Homo sapiens
87 SCYL3 57147
Affinity Capture-MS Homo sapiens
88 SYAP1 94056
Two-hybrid Homo sapiens
89 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 LDLRAD1  
Two-hybrid Homo sapiens
91 LINC00839  
Protein-RNA Homo sapiens
92 IGHG2 3501
Affinity Capture-MS Homo sapiens
93 EBP  
Two-hybrid Homo sapiens
94 DDX58 23586
Affinity Capture-RNA Homo sapiens
95 SERPINB3 6317
Affinity Capture-MS Homo sapiens
96 CLEC10A  
Two-hybrid Homo sapiens
97 ERGIC2 51290
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 OSBPL3 26031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 MRPS18B 28973
Two-hybrid Homo sapiens
100 RAB2A 5862
Proximity Label-MS Homo sapiens
101 RNMTL1  
Two-hybrid Homo sapiens
102 SGMS2 166929
Two-hybrid Homo sapiens
103 GPC3 2719
Affinity Capture-MS Homo sapiens
104 RAB5C 5878
Proximity Label-MS Homo sapiens
105 TMEM31  
Two-hybrid Homo sapiens
106 ELOVL4  
Two-hybrid Homo sapiens
107 PLAC9 219348
Affinity Capture-MS Homo sapiens
108 MGST3 4259
Two-hybrid Homo sapiens
109 KIAA1644  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZFPL1 is involved
No pathways found





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