Gene description for OSBPL2
Gene name oxysterol binding protein-like 2
Gene symbol OSBPL2
Other names/aliases DFNA67
DNFA67
ORP-2
ORP2
Species Homo sapiens
 Database cross references - OSBPL2
ExoCarta ExoCarta_9885
Vesiclepedia VP_9885
Entrez Gene 9885
HGNC 15761
MIM 606731
UniProt Q9H1P3  
 OSBPL2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for OSBPL2
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA
    phosphatidylinositol transfer activity GO:0008526 IMP
    cholesterol binding GO:0015485 IBA
    cholesterol binding GO:0015485 IDA
    sterol transfer activity GO:0120015 TAS
    cholesterol transfer activity GO:0120020 IMP
Biological Process
    bile acid biosynthetic process GO:0006699 TAS
    plasma membrane organization GO:0007009 IMP
    regulation of synaptic vesicle priming GO:0010807 IDA
    phospholipid transport GO:0015914 IMP
    cholesterol transport GO:0030301 IMP
    intracellular cholesterol transport GO:0032367 IMP
    protein homotetramerization GO:0051289 IDA
    regulation of presynaptic cytosolic calcium ion concentration GO:0099509 IEA
    intermembrane lipid transfer GO:0120009 IEA
Subcellular Localization
    lipid droplet GO:0005811 IMP
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    perinuclear endoplasmic reticulum GO:0097038 IBA
    presynaptic active zone cytoplasmic component GO:0098831 IEA
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified OSBPL2 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for OSBPL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSD17B11 51170
Proximity Label-MS Homo sapiens
2 VAPB 9217
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 ZFPL1 7542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 Dennd6a  
Affinity Capture-MS Mus musculus
7 KIAA1715 80856
Proximity Label-MS Homo sapiens
8 RNF14 9604
Affinity Capture-MS Homo sapiens
9 HSD3B7 80270
Proximity Label-MS Homo sapiens
10 HNRNPD 3184
Affinity Capture-MS Homo sapiens
11 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
12 SNAP25 6616
PCA Homo sapiens
Reconstituted Complex Homo sapiens
13 SNRPF 6636
Two-hybrid Homo sapiens
14 BAG6 7917
Affinity Capture-MS Homo sapiens
15 Spire2  
Affinity Capture-MS Mus musculus
16 SGTB  
Affinity Capture-MS Homo sapiens
17 BIRC6 57448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SEC62 7095
Proximity Label-MS Homo sapiens
19 ATP2A1 487
Proximity Label-MS Homo sapiens
20 APBB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 Vamp2  
Affinity Capture-MS Mus musculus
22 CKAP4 10970
Proximity Label-MS Homo sapiens
23 SEC61B 10952
Proximity Label-MS Homo sapiens
24 HUWE1 10075
Affinity Capture-MS Homo sapiens
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