Gene description for SGMS2
Gene name sphingomyelin synthase 2
Gene symbol SGMS2
Other names/aliases SMS2
Species Homo sapiens
 Database cross references - SGMS2
ExoCarta ExoCarta_166929
Vesiclepedia VP_166929
Entrez Gene 166929
HGNC 28395
MIM 611574
UniProt Q8NHU3  
 SGMS2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SGMS2
Molecular Function
    kinase activity GO:0016301 IEA
    sphingomyelin synthase activity GO:0033188 IEA
    ceramide cholinephosphotransferase activity GO:0047493 IDA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    sphingomyelin biosynthetic process GO:0006686 IDA
    phosphorylation GO:0016310 IEA
    sphingolipid metabolic process GO:0006665 TAS
    sphingolipid biosynthetic process GO:0030148 TAS
Subcellular Localization
    integral component of cell outer membrane GO:0045203 IEA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 IDA
    Golgi apparatus GO:0005794 IDA
    integral component of Golgi membrane GO:0030173 IDA
 Experiment description of studies that identified SGMS2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SGMS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SGMS2 is involved
PathwayEvidenceSource
Sphingolipid de novo biosynthesis TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here