Gene description for Fam60a
Gene name family with sequence similarity 60, member A
Gene symbol Fam60a
Other names/aliases Ppcs1
Pptcs1
Tera
Species Mus musculus
 Database cross references - Fam60a
ExoCarta ExoCarta_56306
Vesiclepedia VP_56306
Entrez Gene 56306
UniProt Q8C8M1  
 Fam60a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Fam60a
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 NAS
    positive regulation of cell population proliferation GO:0008284 IMP
    negative regulation of cell migration GO:0030336 IBA
    negative regulation of cell migration GO:0030336 ISO
    negative regulation of cell migration GO:0030336 ISS
    negative regulation of cell migration GO:0030336 NAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 NAS
    negative regulation of cell differentiation GO:0045596 IMP
    negative regulation of stem cell population maintenance GO:1902455 NAS
    positive regulation of stem cell population maintenance GO:1902459 NAS
Subcellular Localization
    nucleus GO:0005634 NAS
    Sin3-type complex GO:0070822 IBA
    Sin3-type complex GO:0070822 ISO
    Sin3-type complex GO:0070822 ISS
    Sin3-type complex GO:0070822 NAS
 Experiment description of studies that identified Fam60a in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Fam60a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FOXK1 221937
Affinity Capture-MS Homo sapiens
2 SAP30 8819
Affinity Capture-MS Homo sapiens
3 TRIM56 81844
Affinity Capture-MS Homo sapiens
4 RBBP7 5931
Affinity Capture-MS Homo sapiens
5 SUDS3  
Affinity Capture-MS Homo sapiens
6 ING1  
Affinity Capture-MS Homo sapiens
7 HDAC2 3066
Affinity Capture-MS Homo sapiens
8 SGMS2 166929
Affinity Capture-MS Homo sapiens
9 HDAC1 3065
Affinity Capture-MS Homo sapiens
10 SAP130  
Affinity Capture-MS Homo sapiens
11 SIN3A  
Affinity Capture-MS Homo sapiens
12 BRMS1 25855
Affinity Capture-MS Homo sapiens
13 ARID4A  
Affinity Capture-MS Homo sapiens
14 CDC42BPA 8476
Affinity Capture-MS Homo sapiens
15 ARID4B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Fam60a is involved
No pathways found





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