Gene description for BRMS1
Gene name breast cancer metastasis suppressor 1
Gene symbol BRMS1
Other names/aliases -
Species Homo sapiens
 Database cross references - BRMS1
ExoCarta ExoCarta_25855
Vesiclepedia VP_25855
Entrez Gene 25855
HGNC 17262
MIM 606259
UniProt Q9HCU9  
 BRMS1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for BRMS1
Molecular Function
    protein binding GO:0005515 IPI
    histone deacetylase binding GO:0042826 IBA
    NF-kappaB binding GO:0051059 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 NAS
    apoptotic process GO:0006915 IEA
    negative regulation of cell migration GO:0030336 NAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 NAS
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    regulation of apoptotic process GO:0042981 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of protein deacetylation GO:0090312 IDA
    negative regulation of stem cell population maintenance GO:1902455 NAS
    positive regulation of stem cell population maintenance GO:1902459 NAS
    positive regulation of anoikis GO:2000210 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    Sin3-type complex GO:0070822 IBA
    Sin3-type complex GO:0070822 NAS
 Experiment description of studies that identified BRMS1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for BRMS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 DZIP3  
Affinity Capture-MS Homo sapiens
3 RELA 5970
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 PADI6  
Affinity Capture-MS Homo sapiens
5 HDAC4  
Affinity Capture-Western Homo sapiens
6 SPOP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 MXD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ELF1 1997
Proximity Label-MS Homo sapiens
10 MCRS1  
Two-hybrid Homo sapiens
11 EEF1A1 1915
Two-hybrid Homo sapiens
12 METTL14  
Affinity Capture-MS Homo sapiens
13 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MAX  
Affinity Capture-MS Homo sapiens
15 SIN3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 NMI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
17 KLF9 687
Proximity Label-MS Homo sapiens
18 TGIF2  
Affinity Capture-MS Homo sapiens
19 FAM60A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 Sin3a  
Affinity Capture-MS Mus musculus
21 TGIF2LX  
Affinity Capture-MS Homo sapiens
22 HDAC5 10014
Affinity Capture-Western Homo sapiens
23 POLR2E 5434
Affinity Capture-MS Homo sapiens
24 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SKP2  
Affinity Capture-MS Homo sapiens
26 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
27 TRIM7  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
28 MXD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CUL3 8452
Affinity Capture-Western Homo sapiens
30 LRIF1  
Two-hybrid Homo sapiens
31 UBE2D1 7321
Reconstituted Complex Homo sapiens
32 CREBBP  
Affinity Capture-Western Homo sapiens
33 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
34 BRMS1 25855
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
35 TAF1  
Two-hybrid Homo sapiens
36 HDAC6 10013
Affinity Capture-Western Homo sapiens
37 SNX6 58533
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
38 SIN3B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 ZNF704  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 KLF16  
Proximity Label-MS Homo sapiens
41 FHL2 2274
Affinity Capture-MS Homo sapiens
42 Max  
Affinity Capture-MS Mus musculus
43 PRPS2 5634
Affinity Capture-MS Homo sapiens
44 SAP30 8819
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
45 HSPA4 3308
Affinity Capture-MS Homo sapiens
46 RBBP4 5928
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
47 WTAP 9589
Affinity Capture-MS Homo sapiens
48 E2F1 1869
Two-hybrid Homo sapiens
49 HDAC3 8841
Reconstituted Complex Homo sapiens
50 ING1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 MBIP  
Affinity Capture-MS Homo sapiens
52 AR 367
Proximity Label-MS Homo sapiens
53 CEP70  
Two-hybrid Homo sapiens
54 FOXK2  
Affinity Capture-MS Homo sapiens
55 DNAJB6 10049
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
56 METTL3  
Affinity Capture-MS Homo sapiens
57 WDR59 79726
Affinity Capture-MS Homo sapiens
58 NFKB1 4790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
59 SMTN 6525
Two-hybrid Homo sapiens
60 DKK2  
Affinity Capture-MS Homo sapiens
61 SAP25  
Affinity Capture-MS Homo sapiens
62 ELF2  
Proximity Label-MS Homo sapiens
63 HNF1B  
Proximity Label-MS Homo sapiens
64 Fam60a 56306
Affinity Capture-MS Mus musculus
65 SMARCE1 6605
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
66 SUDS3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
67 PRPS1 5631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 BRMS1L  
Affinity Capture-MS Homo sapiens
69 KPNA5 3841
Two-hybrid Homo sapiens
70 FOXK1 221937
Affinity Capture-MS Homo sapiens
71 ING2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
73 ARID4A  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
74 GATAD1  
Affinity Capture-MS Homo sapiens
75 GOLGB1 2804
Two-hybrid Homo sapiens
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