Gene description for HDAC6
Gene name	histone deacetylase 6
Gene symbol	HDAC6
Other names/aliases	CPBHM HD6 JM21 PPP1R90
Species	Homo sapiens
Database cross references - HDAC6
ExoCarta	ExoCarta_10013
Entrez Gene	10013
HGNC	14064
MIM	300272
UniProt	Q9UBN7
HDAC6 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for HDAC6

Molecular Function     misfolded protein binding GO:0051787 EXP     beta-catenin binding GO:0008013 IPI     tubulin deacetylase activity GO:0042903 ISS     core promoter binding GO:0001047 IDA     actin binding GO:0003779 IEA     alpha-tubulin binding GO:0043014 IDA     ubiquitin protein ligase binding GO:0031625 IPI     enzyme binding GO:0019899 ISS     dynein complex binding GO:0070840 IDA     histone deacetylase activity GO:0004407 IMP     polyubiquitin binding GO:0031593 IDA     beta-tubulin binding GO:0048487 IEA     NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372 IEA     microtubule binding GO:0008017 ISS     NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 IEA     zinc ion binding GO:0008270 IEA     Hsp90 protein binding GO:0051879 IDA     protein binding GO:0005515 IPI     tau protein binding GO:0048156 IDA     NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 IEA     histone deacetylase binding GO:0042826 IPI     NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969 IEA Biological Process     response to misfolded protein GO:0051788 IMP     histone H4 deacetylation GO:0070933 IEA     histone H3-K9 deacetylation GO:1990619 IEA     cellular response to heat GO:0034605 TAS     polyubiquitinated misfolded protein transport GO:0070845 IMP     negative regulation of protein complex disassembly GO:0043242 IMP     positive regulation of hydrogen peroxide-mediated programmed cell death GO:1901300 IDA     regulation of gene expression, epigenetic GO:0040029 IMP     positive regulation of signal transduction GO:0009967 IMP     regulation of fat cell differentiation GO:0045598 IEA     response to toxic substance GO:0009636 IMP     regulation of microtubule-based movement GO:0060632 IC     transcription, DNA-templated GO:0006351 IEA     misfolded or incompletely synthesized protein catabolic process GO:0006515 IMP     positive regulation of epithelial cell migration GO:0010634 IMP     intracellular protein transport GO:0006886 IMP     response to growth factor GO:0070848 IMP     negative regulation of transcription, DNA-templated GO:0045892 ISS     aggresome assembly GO:0070842 IMP     organelle organization GO:0006996 TAS     positive regulation of chaperone-mediated protein complex assembly GO:0090035 IMP     cellular response to misfolded protein GO:0071218 IEA     positive regulation of receptor biosynthetic process GO:0010870 IMP     ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IEA     lysosome localization GO:0032418 IMP     regulation of receptor activity GO:0010469 IMP     negative regulation of oxidoreductase activity GO:0051354 IC     peptidyl-lysine deacetylation GO:0034983 IMP     Hsp90 deacetylation GO:0070846 IMP     negative regulation of hydrogen peroxide metabolic process GO:0010727 IC     cellular response to hydrogen peroxide GO:0070301 IMP     negative regulation of proteolysis GO:0045861 IMP     protein polyubiquitination GO:0000209 IEA     regulation of androgen receptor signaling pathway GO:0060765 TAS     protein deacetylation GO:0006476 IMP     histone H3-K9 modification GO:0061647 IEA     macroautophagy GO:0016236 IMP     regulation of establishment of protein localization GO:0070201 IEA     protein complex disassembly GO:0043241 IEA     tubulin deacetylation GO:0090042 ISS     response to organic substance GO:0010033 IMP     histone deacetylation GO:0016575 ISS     negative regulation of microtubule depolymerization GO:0007026 IEA     cellular response to topologically incorrect protein GO:0035967 IMP Subcellular Localization     caveola GO:0005901 IDA     inclusion body GO:0016234 IDA     axon GO:0030424 ISS     perinuclear region of cytoplasm GO:0048471 IDA     nucleus GO:0005634 ISS     microtubule GO:0005874 IDA     cell leading edge GO:0031252 IDA     nucleoplasm GO:0005654 IDA     dynein complex GO:0030286 IDA     microtubule associated complex GO:0005875 IDA     histone deacetylase complex GO:0000118 IDA     perikaryon GO:0043204 ISS     aggresome GO:0016235 IDA     cytoplasmic microtubule GO:0005881 IEA     cytoplasm GO:0005737 ISS     dendrite GO:0030425 ISS     cytosol GO:0005829 TAS