Gene description for CIRH1A
Gene name cirrhosis, autosomal recessive 1A (cirhin)
Gene symbol CIRH1A
Other names/aliases CIRHIN
NAIC
TEX292
UTP4
Species Homo sapiens
 Database cross references - CIRH1A
ExoCarta ExoCarta_84916
Vesiclepedia VP_84916
Entrez Gene 84916
HGNC 1983
MIM 607456
UniProt Q969X6  
 CIRH1A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CIRH1A
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000462 IBA
    regulation of DNA-templated transcription GO:0006355 IDA
    maturation of SSU-rRNA GO:0030490 IMP
    ribosomal small subunit biogenesis GO:0042274 IDA
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IDA
    nucleolus GO:0005730 IDA
    90S preribosome GO:0030686 IEA
    small-subunit processome GO:0032040 IBA
    small-subunit processome GO:0032040 IDA
    t-UTP complex GO:0034455 IBA
    t-UTP complex GO:0034455 IDA
 Experiment description of studies that identified CIRH1A in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CIRH1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C9orf78 51759
Affinity Capture-MS Homo sapiens
2 GOLGA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 KLHL20  
Affinity Capture-MS Homo sapiens
5 USP36  
Affinity Capture-MS Homo sapiens
6 GLTSCR2  
Co-fractionation Homo sapiens
7 ISG15 9636
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 MYCN  
Affinity Capture-MS Homo sapiens
10 MPHOSPH6 10200
Affinity Capture-MS Homo sapiens
11 CIRH1A 84916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 EXOSC4 54512
Affinity Capture-MS Homo sapiens
13 ITSN1 6453
Affinity Capture-MS Homo sapiens
14 PARP1 142
Proximity Label-MS Homo sapiens
15 MSMB  
Affinity Capture-MS Homo sapiens
16 NECAB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 KIF14 9928
Affinity Capture-MS Homo sapiens
18 CHCHD1  
Proximity Label-MS Homo sapiens
19 PRNP 5621
Reconstituted Complex Homo sapiens
20 XPO1 7514
Affinity Capture-MS Homo sapiens
21 LMNB1 4001
Affinity Capture-MS Homo sapiens
22 ECT2 1894
Affinity Capture-MS Homo sapiens
23 RIT1 6016
Negative Genetic Homo sapiens
24 SIRT7  
Affinity Capture-MS Homo sapiens
25 HDAC6 10013
Affinity Capture-MS Homo sapiens
26 GOLGA7 51125
Affinity Capture-MS Homo sapiens
27 ANKEF1  
Affinity Capture-MS Homo sapiens
28 SSSCA1 10534
Affinity Capture-MS Homo sapiens
29 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 Nrip3  
Affinity Capture-MS Mus musculus
31 NOP56 10528
Affinity Capture-MS Homo sapiens
32 CD6 923
Affinity Capture-MS Homo sapiens
33 CERK 64781
Affinity Capture-MS Homo sapiens
34 CNRIP1 25927
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 USP11 8237
Affinity Capture-MS Homo sapiens
36 PCBP1 5093
Affinity Capture-MS Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 FMOD 2331
Affinity Capture-MS Homo sapiens
39 UTP15 84135
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 IKZF1  
Affinity Capture-MS Homo sapiens
41 EVL 51466
Affinity Capture-MS Homo sapiens
42 RBM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 VASP 7408
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
45 PSMD14 10213
Affinity Capture-MS Homo sapiens
46 NOL11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 AURKB 9212
Affinity Capture-MS Homo sapiens
48 GRSF1 2926
Proximity Label-MS Homo sapiens
49 VPS26A 9559
Affinity Capture-MS Homo sapiens
50 KIF20A 10112
Affinity Capture-MS Homo sapiens
51 PLEKHG4  
Affinity Capture-MS Homo sapiens
52 NOL7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 CCL3L1  
Affinity Capture-MS Homo sapiens
54 MOV10 4343
Affinity Capture-RNA Homo sapiens
55 CHMP4B 128866
Affinity Capture-MS Homo sapiens
56 C1D  
Affinity Capture-MS Homo sapiens
57 KIF22  
Affinity Capture-MS Homo sapiens
58 KIF23 9493
Affinity Capture-MS Homo sapiens
59 DNAJC9 23234
Proximity Label-MS Homo sapiens
60 EGFR 1956
Negative Genetic Homo sapiens
61 IFI16 3428
Affinity Capture-MS Homo sapiens
62 NFKBIL1  
Affinity Capture-MS Homo sapiens
63 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
64 EXOSC5 56915
Affinity Capture-MS Homo sapiens
65 WDR75  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 THBS3 7059
Affinity Capture-MS Homo sapiens
67 FOS 2353
Affinity Capture-MS Homo sapiens
68 PRC1 9055
Affinity Capture-MS Homo sapiens
69 WDR43 23160
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
71 RNF2  
Affinity Capture-MS Homo sapiens
72 RRP9 9136
Affinity Capture-MS Homo sapiens
73 FBL 2091
Affinity Capture-MS Homo sapiens
74 MAD2L1 4085
Affinity Capture-MS Homo sapiens
75 OBSL1 23363
Affinity Capture-MS Homo sapiens
76 RPA3 6119
Proximity Label-MS Homo sapiens
77 AK1 203
Affinity Capture-MS Homo sapiens
78 ANKRD28 23243
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 ARHGAP11A  
Affinity Capture-MS Homo sapiens
80 FBXL19  
Affinity Capture-MS Homo sapiens
81 DDX3Y 8653
Affinity Capture-MS Homo sapiens
82 NPM1 4869
Affinity Capture-MS Homo sapiens
83 PAGE1  
Affinity Capture-MS Homo sapiens
84 BRCA1 672
Affinity Capture-MS Homo sapiens
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