Gene description for IFI16
Gene name	interferon, gamma-inducible protein 16
Gene symbol	IFI16
Other names/aliases	IFNGIP1 PYHIN2
Species	Homo sapiens
Database cross references - IFI16
ExoCarta	ExoCarta_3428
Entrez Gene	3428
HGNC	5395
MIM	147586
UniProt	Q16666
IFI16 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for IFI16

Molecular Function     transcription factor binding GO:0008134 IDA     poly(A) RNA binding GO:0044822 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA     core promoter binding GO:0001047 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA     protein binding GO:0005515 IPI     identical protein binding GO:0042802 IPI     double-stranded DNA binding GO:0003690 IDA Biological Process     negative regulation of innate immune response GO:0045824 IDA     cellular response to ionizing radiation GO:0071479 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     inflammatory response GO:0006954 IEA     regulation of autophagy GO:0010506 IEP     negative regulation of cysteine-type endopeptidase activity GO:2000117 IDA     negative regulation of viral genome replication GO:0045071 IDA     cell proliferation GO:0008283 NAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     autophagy GO:0006914 IEA     activation of cysteine-type endopeptidase activity GO:0097202 IMP     regulation of gene expression, epigenetic GO:0040029 IMP     innate immune response GO:0045087 TAS     myeloid cell differentiation GO:0030099 NAS     defense response to virus GO:0051607 IMP     negative regulation of transcription, DNA-templated GO:0045892 IDA     positive regulation of type I interferon production GO:0032481 TAS     positive regulation of interleukin-1 beta production GO:0032731 IDA     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IDA     negative regulation of DNA binding GO:0043392 IDA     activation of innate immune response GO:0002218 IDA     cellular response to glucose starvation GO:0042149 IDA     hemopoiesis GO:0030097 NAS     transcription, DNA-templated GO:0006351 IEA     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IMP     positive regulation of cytokine production GO:0001819 TAS     monocyte differentiation GO:0030224 IDA Subcellular Localization     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 IDA     nuclear speck GO:0016607 IDA     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IDA     membrane GO:0016020 IDA     nucleus GO:0005634 IDA