Gene description for S100A8
Gene name S100 calcium binding protein A8
Gene symbol S100A8
Other names/aliases 60B8AG
CAGA
CFAG
CGLA
CP-10
L1Ag
MA387
MIF
MRP8
NIF
P8
Species Homo sapiens
 Database cross references - S100A8
ExoCarta ExoCarta_6279
Vesiclepedia VP_6279
Entrez Gene 6279
HGNC 10498
MIM 123885
UniProt P05109  
 S100A8 identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
Cholangiocarcinoma cells 31054213    
Cholangiocarcinoma cells 31054213    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Liver cancer cells 25265333    
Liver cancer cells 25265333    
Mesenchymal stem cells Unpublished / Not applicable
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Saliva 19199708    
Squamous carcinoma cells 20124223    
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for S100A8
Molecular Function
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 TAS
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 TAS
    zinc ion binding GO:0008270 TAS
    Toll-like receptor 4 binding GO:0035662 TAS
    calcium-dependent protein binding GO:0048306 IBA
    arachidonate binding GO:0050544 TAS
    RAGE receptor binding GO:0050786 TAS
Biological Process
    leukocyte migration involved in inflammatory response GO:0002523 IBA
    leukocyte migration involved in inflammatory response GO:0002523 IDA
    chronic inflammatory response GO:0002544 IEA
    peptide secretion GO:0002790 IEA
    positive regulation of peptide secretion GO:0002793 IEA
    autophagy GO:0006914 IDA
    apoptotic process GO:0006915 IEA
    inflammatory response GO:0006954 TAS
    response to zinc ion GO:0010043 IEA
    astrocyte development GO:0014002 IEA
    peptidyl-cysteine S-nitrosylation GO:0018119 IMP
    positive regulation of cell growth GO:0030307 TAS
    neutrophil chemotaxis GO:0030593 IBA
    neutrophil chemotaxis GO:0030593 IDA
    sequestering of zinc ion GO:0032119 TAS
    response to lipopolysaccharide GO:0032496 IBA
    regulation of toll-like receptor signaling pathway GO:0034121 NAS
    autocrine signaling GO:0035425 IEA
    defense response to bacterium GO:0042742 TAS
    endothelial cell migration GO:0043542 IBA
    innate immune response GO:0045087 IEA
    response to ethanol GO:0045471 IEA
    positive regulation of inflammatory response GO:0050729 IDA
    defense response to fungus GO:0050832 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS
    regulation of cytoskeleton organization GO:0051493 TAS
    neutrophil aggregation GO:0070488 IBA
    neutrophil aggregation GO:0070488 IDA
    positive regulation of cysteine-type endopeptidase activity GO:2001056 IDA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IDA
Subcellular Localization
    extracellular region GO:0005576 HDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 HDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 TAS
    plasma membrane GO:0005886 TAS
    secretory granule lumen GO:0034774 TAS
    intermediate filament cytoskeleton GO:0045111 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
    extracellular exosome GO:0070062 HDA
    calprotectin complex GO:1990660 IPI
    calprotectin complex GO:1990660 ISO
 Experiment description of studies that identified S100A8 in exosomes
1
Experiment ID 76
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 1221
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 31054213    
Organism Homo sapiens
Experiment description Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma
Authors "Weeraphan C, Phongdara A, Chaiyawat P, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Verathamjamras C, Netsirisawan P, Yingchutrakul Y, Roytrakul S, Champattanachai V, Svasti J, Srisomsap C."
Journal name Proteomics
Publication year 2019
Sample Cholangiocarcinoma cells
Sample name KKU-M213
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 1222
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 31054213    
Organism Homo sapiens
Experiment description Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma
Authors "Weeraphan C, Phongdara A, Chaiyawat P, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Verathamjamras C, Netsirisawan P, Yingchutrakul Y, Roytrakul S, Champattanachai V, Svasti J, Srisomsap C."
Journal name Proteomics
Publication year 2019
Sample Cholangiocarcinoma cells
Sample name KKU-M213D5
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 266
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Wild type
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 268
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx-null HBV replicon plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
14
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
18
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
20
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
21
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for S100A8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALY 22913
Affinity Capture-MS Homo sapiens
2 EDEM1  
Affinity Capture-MS Homo sapiens
3 RPL26L1 51121
Affinity Capture-MS Homo sapiens
4 SERPINB4 6318
Affinity Capture-MS Homo sapiens
5 TCEB1 6921
Affinity Capture-MS Homo sapiens
6 PHF21B  
Affinity Capture-MS Homo sapiens
7 PAXIP1  
Affinity Capture-MS Homo sapiens
8 POT1  
Affinity Capture-MS Homo sapiens
9 ANXA2 302
Affinity Capture-MS Homo sapiens
10 MARCH2  
Affinity Capture-MS Homo sapiens
11 GDF9 2661
Two-hybrid Homo sapiens
12 MPO 4353
Co-fractionation Homo sapiens
13 CSTA 1475
Affinity Capture-MS Homo sapiens
14 VHL  
Affinity Capture-MS Homo sapiens
15 ST7  
Affinity Capture-MS Homo sapiens
16 AZGP1 563
Affinity Capture-MS Homo sapiens
17 FNDC5  
Affinity Capture-MS Homo sapiens
18 KIAA1429 25962
Affinity Capture-MS Homo sapiens
19 B3GNT2 10678
Affinity Capture-MS Homo sapiens
20 RNF5  
Affinity Capture-MS Homo sapiens
21 CEMIP 57214
Affinity Capture-MS Homo sapiens
22 MCM2 4171
Affinity Capture-MS Homo sapiens
23 COPS5 10987
Affinity Capture-MS Homo sapiens
24 FBXW7  
Affinity Capture-MS Homo sapiens
25 NUDT3 11165
Affinity Capture-MS Homo sapiens
26 ELF1 1997
Proximity Label-MS Homo sapiens
27 ARHGEF10 9639
Affinity Capture-MS Homo sapiens
28 USF2 7392
Affinity Capture-MS Homo sapiens
29 CHGB 1114
Two-hybrid Homo sapiens
30 SLX4  
Affinity Capture-MS Homo sapiens
31 SHC1 6464
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 C14orf1 11161
Two-hybrid Homo sapiens
33 C18orf21  
Affinity Capture-MS Homo sapiens
34 GSK3B 2932
Affinity Capture-MS Homo sapiens
35 PPM1B 5495
Affinity Capture-MS Homo sapiens
36 NF2 4771
Affinity Capture-MS Homo sapiens
37 DLD 1738
Affinity Capture-MS Homo sapiens
38 OCRL 4952
Affinity Capture-MS Homo sapiens
39 CDKN1A  
Two-hybrid Homo sapiens
40 PARK2  
Affinity Capture-MS Homo sapiens
41 TUBA1A 7846
Reconstituted Complex Homo sapiens
42 WRAP73 49856
Affinity Capture-MS Homo sapiens
43 LRIF1  
Two-hybrid Homo sapiens
44 Tuba1a 22142
Two-hybrid Mus musculus
45 UBASH3B 84959
Affinity Capture-MS Homo sapiens
46 EFHD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SMTNL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TRIM21 6737
Affinity Capture-MS Homo sapiens
49 SARAF  
Affinity Capture-MS Homo sapiens
50 PIGT 51604
Affinity Capture-MS Homo sapiens
51 IFI16 3428
Affinity Capture-MS Homo sapiens
52 ARNT 405
Affinity Capture-MS Homo sapiens
53 SPRR2E  
Affinity Capture-MS Homo sapiens
54 RPL36 25873
Affinity Capture-MS Homo sapiens
55 UNC119 9094
Two-hybrid Homo sapiens
56 ALB 213
Co-fractionation Homo sapiens
57 APTX  
Affinity Capture-MS Homo sapiens
58 UPK1A 11045
Affinity Capture-MS Homo sapiens
59 DDX39B 7919
Affinity Capture-MS Homo sapiens
60 CYLD  
Affinity Capture-MS Homo sapiens
61 PHF11 51131
Affinity Capture-MS Homo sapiens
62 CNR2  
Affinity Capture-MS Homo sapiens
63 HIST1H2AI 8329
Affinity Capture-MS Homo sapiens
64 BAG3 9531
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
65 CASP14 23581
Affinity Capture-MS Homo sapiens
66 RHBDD1 84236
Affinity Capture-MS Homo sapiens
67 BRF1  
Affinity Capture-MS Homo sapiens
68 TUBB 203068
Reconstituted Complex Homo sapiens
69 SERPINB3 6317
Affinity Capture-MS Homo sapiens
70 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
71 FANCD2  
Affinity Capture-MS Homo sapiens
72 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
73 AGPAT1 10554
Affinity Capture-MS Homo sapiens
74 DOCK8 81704
Affinity Capture-MS Homo sapiens
75 S100A7 6278
Affinity Capture-MS Homo sapiens
76 NR3C1 2908
Affinity Capture-MS Homo sapiens
77 CCNYL1 151195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 SIRT7  
Affinity Capture-MS Homo sapiens
79 EPAS1  
Affinity Capture-MS Homo sapiens
80 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 TRAF3IP1 26146
Affinity Capture-MS Homo sapiens
82 TFAP4 7023
Affinity Capture-MS Homo sapiens
83 SLX1B  
Affinity Capture-MS Homo sapiens
84 SETD8  
Affinity Capture-MS Homo sapiens
85 PPIA 5478
Two-hybrid Homo sapiens
86 NUAK1  
Affinity Capture-MS Homo sapiens
87 LGALS7 3963
Affinity Capture-MS Homo sapiens
88 AURKB 9212
Affinity Capture-MS Homo sapiens
89 CDK2 1017
Affinity Capture-MS Homo sapiens
90 LRRK1 79705
Affinity Capture-MS Homo sapiens
91 SSUH2  
Affinity Capture-MS Homo sapiens
92 FABP5 2171
Affinity Capture-MS Homo sapiens
93 RPA3 6119
Proximity Label-MS Homo sapiens
94 RPL35A 6165
Affinity Capture-MS Homo sapiens
95 TCEB2 6923
Affinity Capture-MS Homo sapiens
96 PDCD11 22984
Two-hybrid Homo sapiens
97 RIPPLY3  
Affinity Capture-MS Homo sapiens
98 DPH6  
Affinity Capture-MS Homo sapiens
99 APP 351
Reconstituted Complex Homo sapiens
100 ASB3 51130
Affinity Capture-MS Homo sapiens
101 TERF2  
Affinity Capture-MS Homo sapiens
102 SIRT6  
Affinity Capture-MS Homo sapiens
103 GRB2 2885
Affinity Capture-MS Homo sapiens
104 CUL2 8453
Affinity Capture-MS Homo sapiens
105 TP53 7157
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
106 DOCK5 80005
Affinity Capture-MS Homo sapiens
107 SH2D3A  
Affinity Capture-MS Homo sapiens
108 MCM5 4174
Affinity Capture-MS Homo sapiens
109 ERCC8  
Affinity Capture-MS Homo sapiens
110 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
111 C1orf35  
Affinity Capture-MS Homo sapiens
112 DMWD  
Affinity Capture-MS Homo sapiens
113 PTDSS1 9791
Affinity Capture-MS Homo sapiens
114 S100A9 6280
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
115 DDX58 23586
Affinity Capture-RNA Homo sapiens
116 NCF2 4688
Reconstituted Complex Homo sapiens
117 S100A8 6279
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
118 ESR1  
Affinity Capture-MS Homo sapiens
119 ERCC3  
Affinity Capture-MS Homo sapiens
120 TERF1 7013
Affinity Capture-MS Homo sapiens
121 KDM1A 23028
Affinity Capture-MS Homo sapiens
122 BECN1 8678