Gene description for USF2
Gene name upstream transcription factor 2, c-fos interacting
Gene symbol USF2
Other names/aliases FIP
bHLHb12
Species Homo sapiens
 Database cross references - USF2
ExoCarta ExoCarta_7392
Entrez Gene 7392
HGNC 12594
MIM 600390
UniProt Q15853  
 USF2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for USF2
Molecular Function
    double-stranded DNA binding GO:0003690 IEA
    sequence-specific DNA binding GO:0043565 IDA
    protein binding GO:0005515 IPI
    bHLH transcription factor binding GO:0043425 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IMP
    protein homodimerization activity GO:0042803 IPI
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    lactation GO:0007595 IEA
    late viral transcription GO:0019086 IC
    transcription from RNA polymerase II promoter GO:0006366 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    regulation of transcription from RNA polymerase II promoter by glucose GO:0000430 IC
    lipid homeostasis GO:0055088 ISS
    positive regulation of transcription from RNA polymerase II promoter by glucose GO:0000432 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified USF2 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for USF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPRC1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 MAF  
Reconstituted Complex Homo sapiens
3 HSPA4L 22824
Affinity Capture-MS Homo sapiens
4 SERPINB4 6318
Affinity Capture-MS Homo sapiens
5 S100A9 6280
Affinity Capture-MS Homo sapiens
6 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 NPM1 4869
Affinity Capture-MS Homo sapiens
8 USF1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
9 FUS 2521
Affinity Capture-MS Homo sapiens
10 SERPINB3 6317
Affinity Capture-MS Homo sapiens
11 USF2 7392
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 PTP4A2 8073
Affinity Capture-MS Homo sapiens
13 EP300 2033
Two-hybrid Homo sapiens
14 BIRC5  
Affinity Capture-MS Homo sapiens
15 S100A8 6279
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which USF2 is involved
No pathways found





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