Gene description for VEGFA
Gene name vascular endothelial growth factor A
Gene symbol VEGFA
Other names/aliases MVCD1
VEGF
VPF
Species Homo sapiens
 Database cross references - VEGFA
ExoCarta ExoCarta_7422
Vesiclepedia VP_7422
Entrez Gene 7422
HGNC 12680
MIM 192240
UniProt P15692  
 VEGFA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VEGFA
Molecular Function
    neuropilin binding GO:0038191 IPI
    protein homodimerization activity GO:0042803 ISS
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    cytokine activity GO:0005125 ISS
    extracellular matrix binding GO:0050840 IC
    receptor agonist activity GO:0048018 IPI
    platelet-derived growth factor receptor binding GO:0005161 IPI
    vascular endothelial growth factor receptor binding GO:0005172 IPI
    chemoattractant activity GO:0042056 IDA
    vascular endothelial growth factor receptor 1 binding GO:0043183 IPI
    fibronectin binding GO:0001968 IDA
    vascular endothelial growth factor receptor 2 binding GO:0043184 IPI
    protein heterodimerization activity GO:0046982 IDA
    heparin binding GO:0008201 IMP
    growth factor activity GO:0008083 ISS
Biological Process
    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 IDA
    dopaminergic neuron differentiation GO:0071542 ISS
    regulation of cGMP metabolic process GO:0030823 IDA
    platelet degranulation GO:0002576 TAS
    positive regulation of protein autophosphorylation GO:0031954 IDA
    positive regulation of protein phosphorylation GO:0001934 IDA
    positive regulation of axon extension involved in axon guidance GO:0048842 ISS
    artery morphogenesis GO:0048844 ISS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    tube formation GO:0035148 IDA
    positive regulation of endothelial cell migration GO:0010595 IDA
    cellular response to hypoxia GO:0071456 TAS
    lactation GO:0007595 ISS
    positive regulation of mesenchymal cell proliferation GO:0002053 ISS
    positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 IDA
    response to hypoxia GO:0001666 IDA
    positive regulation of cell migration GO:0030335 IDA
    nervous system development GO:0007399 TAS
    platelet activation GO:0030168 TAS
    coronary vein morphogenesis GO:0003169 ISS
    positive regulation of leukocyte migration GO:0002687 TAS
    positive regulation of vascular permeability GO:0043117 IDA
    post-embryonic camera-type eye development GO:0031077 ISS
    outflow tract morphogenesis GO:0003151 ISS
    kidney development GO:0001822 ISS
    positive regulation of cell proliferation GO:0008284 IDA
    positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 IDA
    epithelial cell differentiation GO:0030855 ISS
    branching morphogenesis of an epithelial tube GO:0048754 ISS
    vasculogenesis GO:0001570 TAS
    positive regulation of receptor internalization GO:0002092 IDA
    positive regulation of protein kinase C signaling GO:0090037 IDA
    primitive erythrocyte differentiation GO:0060319 ISS
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 IMP
    positive regulation of cellular component movement GO:0051272 IDA
    eye photoreceptor cell development GO:0042462 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    positive regulation of histone deacetylase activity GO:1901727 IDA
    positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 IDA
    positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 ISS
    growth GO:0040007 ISS
    lymph vessel morphogenesis GO:0036303 ISS
    cell migration involved in sprouting angiogenesis GO:0002042 IDA
    blood coagulation GO:0007596 TAS
    positive regulation of angiogenesis GO:0045766 IMP
    positive regulation of gene expression GO:0010628 IDA
    endothelial cell chemotaxis GO:0035767 IDA
    positive chemotaxis GO:0050918 IDA
    regulation of cell shape GO:0008360 IDA
    heart morphogenesis GO:0003007 ISS
    positive regulation of protein localization to early endosome GO:1902966 IDA
    monocyte differentiation GO:0030224 IDA
    cardiac muscle fiber development GO:0048739 ISS
    macrophage differentiation GO:0030225 IDA
    positive regulation of mast cell chemotaxis GO:0060754 IDA
    mammary gland alveolus development GO:0060749 ISS
    positive regulation of cell division GO:0051781 IEA
    induction of positive chemotaxis GO:0050930 NAS
    positive regulation of endothelial cell proliferation GO:0001938 ISS
    ovarian follicle development GO:0001541 ISS
    positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 IDA
    positive regulation of retinal ganglion cell axon guidance GO:1902336 ISS
    angiogenesis GO:0001525 IDA
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IDA
    positive regulation of CREB transcription factor activity GO:0032793 IDA
    positive regulation of cell adhesion GO:0045785 IDA
    positive regulation of p38MAPK cascade GO:1900745 IDA
    basophil chemotaxis GO:0002575 IDA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    vascular endothelial growth factor signaling pathway GO:0038084 IDA
    regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS
    positive regulation of protein complex assembly GO:0031334 IDA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    patterning of blood vessels GO:0001569 ISS
    in utero embryonic development GO:0001701 ISS
    commissural neuron axon guidance GO:0071679 ISS
    lung development GO:0030324 ISS
    positive regulation of epithelial cell proliferation GO:0050679 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    mesoderm development GO:0007498 ISS
    positive regulation of protein kinase D signaling GO:1903572 IDA
    positive regulation of focal adhesion assembly GO:0051894 IDA
    positive regulation of blood vessel endothelial cell migration GO:0043536 IDA
    cell maturation GO:0048469 ISS
    activation of protein kinase activity GO:0032147 IDA
    positive regulation of positive chemotaxis GO:0050927 IDA
    positive regulation of MAP kinase activity GO:0043406 IDA
    surfactant homeostasis GO:0043129 ISS
    VEGF-activated neuropilin signaling pathway GO:0038190 ISS
    camera-type eye morphogenesis GO:0048593 ISS
    coronary artery morphogenesis GO:0060982 ISS
    cardiac vascular smooth muscle cell development GO:0060948 ISS
    positive regulation of neuroblast proliferation GO:0002052 ISS
    regulation of retinal ganglion cell axon guidance GO:0090259 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IEA
    proteinaceous extracellular matrix GO:0005578 NAS
    platelet alpha granule lumen GO:0031093 TAS
    secretory granule GO:0030141 IDA
    extracellular region GO:0005576 TAS
    cell surface GO:0009986 IDA
    extracellular space GO:0005615 ISS
 Experiment description of studies that identified VEGFA in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VEGFA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VTN 7448
Reconstituted Complex Homo sapiens
2 SPARC 6678
Far Western Homo sapiens
3 IGFBP7 3490
Reconstituted Complex Homo sapiens
4 GPC1 2817
Reconstituted Complex Homo sapiens
5 NRP1 8829
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
6 ADAMTS1 9510
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 VEGFA 7422
Invivo Homo sapiens
Invitro Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
8 SEMA3F 6405
Invitro Homo sapiens
Invivo Homo sapiens
9 KDR  
Biochemical Activity Homo sapiens
10 PGF  
Co-purification Homo sapiens
11 CTGF 1490
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
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