Gene description for UBIAD1
Gene name UbiA prenyltransferase domain containing 1
Gene symbol UBIAD1
Other names/aliases SCCD
TERE1
Species Homo sapiens
 Database cross references - UBIAD1
ExoCarta ExoCarta_29914
Vesiclepedia VP_29914
Entrez Gene 29914
HGNC 30791
MIM 611632
UniProt Q9Y5Z9  
 UBIAD1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for UBIAD1
Molecular Function
    prenyltransferase activity GO:0004659 EXP
    prenyltransferase activity GO:0004659 IBA
    prenyltransferase activity GO:0004659 IDA
    protein binding GO:0005515 IPI
    antioxidant activity GO:0016209 IMP
Biological Process
    ubiquinone biosynthetic process GO:0006744 IMP
    menaquinone biosynthetic process GO:0009234 IBA
    menaquinone biosynthetic process GO:0009234 IEA
    menaquinone biosynthetic process GO:0009234 IMP
    ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate GO:0032194 IBA
    vitamin K biosynthetic process GO:0042371 IBA
    vitamin K biosynthetic process GO:0042371 IDA
    vitamin K biosynthetic process GO:0042371 IMP
    vitamin K metabolic process GO:0042373 TAS
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 IDA
    mitochondrial membrane GO:0031966 IEA
 Experiment description of studies that identified UBIAD1 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for UBIAD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLDN7 1366
Two-hybrid Homo sapiens
2 PIGP  
Two-hybrid Homo sapiens
3 LHFPL5  
Two-hybrid Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 TMEM14B  
Two-hybrid Homo sapiens
6 RAB35 11021
Proximity Label-MS Homo sapiens
7 TMED10 10972
Affinity Capture-MS Homo sapiens
8 MGST3 4259
Two-hybrid Homo sapiens
9 GORASP2 26003
Affinity Capture-MS Homo sapiens
10 FAM134C 162427
Two-hybrid Homo sapiens
11 CREB3L1  
Two-hybrid Homo sapiens
12 OCLN 100506658
Proximity Label-MS Homo sapiens
13 METTL7A 25840
Proximity Label-MS Homo sapiens
14 LAMTOR1 55004
Proximity Label-MS Homo sapiens
15 MARCKS 4082
Proximity Label-MS Homo sapiens
16 LAMP3  
Proximity Label-MS Homo sapiens
17 RAB5A 5868
Proximity Label-MS Homo sapiens
18 PANX1 24145
Proximity Label-MS Homo sapiens
19 GJA1 2697
Proximity Label-MS Homo sapiens
20 NUP155 9631
Proximity Label-MS Homo sapiens
21 PXMP2  
Proximity Label-MS Homo sapiens
22 CD53 963
Two-hybrid Homo sapiens
23 RAB9A 9367
Proximity Label-MS Homo sapiens
24 LAMP1 3916
Proximity Label-MS Homo sapiens
25 Nrip3  
Affinity Capture-MS Mus musculus
26 ASGR2  
Two-hybrid Homo sapiens
27 ERGIC3 51614
Two-hybrid Homo sapiens
28 BCAP31 10134
Proximity Label-MS Homo sapiens
29 HSD3B7 80270
Proximity Label-MS Homo sapiens
30 LMAN1 3998
Proximity Label-MS Homo sapiens
31 HMGCR  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
32 EMD 2010
Proximity Label-MS Homo sapiens
33 LAMP2 3920
Proximity Label-MS Homo sapiens
34 CD33 945
Two-hybrid Homo sapiens
35 REEP4  
Two-hybrid Homo sapiens
36 ARF6 382
Proximity Label-MS Homo sapiens
37 CD79A  
Two-hybrid Homo sapiens
38 RIOK3 8780
Affinity Capture-MS Homo sapiens
39 ERGIC1 57222
Proximity Label-MS Homo sapiens
40 AHNAK2 113146
Two-hybrid Homo sapiens
41 TMEFF2  
Two-hybrid Homo sapiens
42 RAB4A 5867
Proximity Label-MS Homo sapiens
43 GPR152  
Two-hybrid Homo sapiens
44 FAM209A 200232
Two-hybrid Homo sapiens
45 TMEM139  
Two-hybrid Homo sapiens
46 ERGIC2 51290
Proximity Label-MS Homo sapiens
47 EBP  
Two-hybrid Homo sapiens
48 EVI2B 2124
Two-hybrid Homo sapiens
49 SOAT1 6646
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
50 B3GAT1  
Proximity Label-MS Homo sapiens
51 RAB2A 5862
Proximity Label-MS Homo sapiens
52 RNMTL1  
Two-hybrid Homo sapiens
53 Uso1 56041
Affinity Capture-MS Mus musculus
54 Tpx2  
Affinity Capture-MS Mus musculus
55 ATP2A1 487
Proximity Label-MS Homo sapiens
56 HIBADH 11112
Two-hybrid Homo sapiens
57 CPLX4  
Two-hybrid Homo sapiens
58 RAB11A 8766
Proximity Label-MS Homo sapiens
59 GOLGA1  
Proximity Label-MS Homo sapiens
60 CRB3 92359
Two-hybrid Homo sapiens
61 RAB3B 5865
Proximity Label-MS Homo sapiens
62 SERBP1 26135
Affinity Capture-MS Homo sapiens
63 KCNJ6  
Two-hybrid Homo sapiens
64 RPN1 6184
Proximity Label-MS Homo sapiens
65 KRAS 3845
Proximity Label-MS Homo sapiens
66 RAB5C 5878
Proximity Label-MS Homo sapiens
67 RHOB 388
Proximity Label-MS Homo sapiens
68 ADD1 118
Affinity Capture-MS Homo sapiens
69 SSR1 6745
Proximity Label-MS Homo sapiens
70 STX4 6810
Proximity Label-MS Homo sapiens
71 FNDC9  
Two-hybrid Homo sapiens
72 VEGFA 7422
Two-hybrid Homo sapiens
73 SEC62 7095
Proximity Label-MS Homo sapiens
74 SCN3B  
Two-hybrid Homo sapiens
75 ELOVL5 60481
Proximity Label-MS Homo sapiens
76 GJD3  
Proximity Label-MS Homo sapiens
77 FCER1G 2207
Two-hybrid Homo sapiens
78 RPN2 6185
Proximity Label-MS Homo sapiens
79 EVI2A  
Two-hybrid Homo sapiens
80 STX6 10228
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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