Gene description for SPARC
Gene name	secreted protein, acidic, cysteine-rich (osteonectin)
Gene symbol	SPARC
Other names/aliases	ON
Species	Homo sapiens
Database cross references - SPARC
ExoCarta	ExoCarta_6678
Entrez Gene	6678
HGNC	11219
MIM	182120
UniProt	P09486
SPARC identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for SPARC

Molecular Function     extracellular matrix binding GO:0050840 IEA     protein binding GO:0005515 IPI     collagen binding GO:0005518 IDA     calcium ion binding GO:0005509 IDA Biological Process     ossification GO:0001503 IEA     positive regulation of endothelial cell migration GO:0010595 IDA     inner ear development GO:0048839 IEA     response to lead ion GO:0010288 IEA     response to cAMP GO:0051591 IEA     response to cadmium ion GO:0046686 IEA     blood coagulation GO:0007596 TAS     lung development GO:0030324 IEA     response to gravity GO:0009629 IEA     negative regulation of endothelial cell proliferation GO:0001937 IDA     response to cytokine GO:0034097 IEA     cellular response to growth factor stimulus GO:0071363 IEA     negative regulation of angiogenesis GO:0016525 IDA     response to glucocorticoid GO:0051384 IEA     heart development GO:0007507 IEA     response to L-ascorbic acid GO:0033591 IEA     response to ethanol GO:0045471 IEA     response to lipopolysaccharide GO:0032496 IEA     extracellular matrix organization GO:0030198 TAS     response to peptide hormone GO:0043434 IEA     receptor-mediated endocytosis GO:0006898 TAS     response to calcium ion GO:0051592 IEA     bone development GO:0060348 IEA     signal transduction GO:0007165 IEA     platelet degranulation GO:0002576 TAS     regulation of cell morphogenesis GO:0022604 IDA     platelet activation GO:0030168 TAS Subcellular Localization     platelet alpha granule lumen GO:0031093 TAS     cell surface GO:0009986 IDA     platelet alpha granule membrane GO:0031092 IDA     platelet alpha granule GO:0031091 IDA     nuclear matrix GO:0016363 IDA     extracellular region GO:0005576 TAS     cytoplasm GO:0005737 IDA     basement membrane GO:0005604 IEA     extracellular space GO:0005615 IEA     plasma membrane GO:0005886 IDA     endocytic vesicle lumen GO:0071682 TAS     mitochondrion GO:0005739 IDA