Gene description for SPARC
Gene name secreted protein, acidic, cysteine-rich (osteonectin)
Gene symbol SPARC
Other names/aliases ON
Species Homo sapiens
 Database cross references - SPARC
ExoCarta ExoCarta_6678
Entrez Gene 6678
HGNC 11219
MIM 182120
UniProt P09486  
 SPARC identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SPARC
Molecular Function
    extracellular matrix binding GO:0050840 IEA
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 IDA
    calcium ion binding GO:0005509 IDA
Biological Process
    ossification GO:0001503 IEA
    positive regulation of endothelial cell migration GO:0010595 IDA
    inner ear development GO:0048839 IEA
    response to lead ion GO:0010288 IEA
    response to cAMP GO:0051591 IEA
    response to cadmium ion GO:0046686 IEA
    blood coagulation GO:0007596 TAS
    lung development GO:0030324 IEA
    response to gravity GO:0009629 IEA
    negative regulation of endothelial cell proliferation GO:0001937 IDA
    response to cytokine GO:0034097 IEA
    cellular response to growth factor stimulus GO:0071363 IEA
    negative regulation of angiogenesis GO:0016525 IDA
    response to glucocorticoid GO:0051384 IEA
    heart development GO:0007507 IEA
    response to L-ascorbic acid GO:0033591 IEA
    response to ethanol GO:0045471 IEA
    response to lipopolysaccharide GO:0032496 IEA
    extracellular matrix organization GO:0030198 TAS
    response to peptide hormone GO:0043434 IEA
    receptor-mediated endocytosis GO:0006898 TAS
    response to calcium ion GO:0051592 IEA
    bone development GO:0060348 IEA
    signal transduction GO:0007165 IEA
    platelet degranulation GO:0002576 TAS
    regulation of cell morphogenesis GO:0022604 IDA
    platelet activation GO:0030168 TAS
Subcellular Localization
    platelet alpha granule lumen GO:0031093 TAS
    cell surface GO:0009986 IDA
    platelet alpha granule membrane GO:0031092 IDA
    platelet alpha granule GO:0031091 IDA
    nuclear matrix GO:0016363 IDA
    extracellular region GO:0005576 TAS
    cytoplasm GO:0005737 IDA
    basement membrane GO:0005604 IEA
    extracellular space GO:0005615 IEA
    plasma membrane GO:0005886 IDA
    endocytic vesicle lumen GO:0071682 TAS
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified SPARC in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SPARC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPARC 6678
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 PDGFA 5154
Invitro Homo sapiens
3 COL1A1 1277
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
4 COL3A1 1281
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
5 VEGF  
Far Western Homo sapiens
6 PLAT 5327
Affinity Capture-MS Homo sapiens
7 TGM2 7052
Affinity Capture-MS Homo sapiens
8 TGFB1 7040
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
9 COL5A1 1289
Reconstituted Complex Homo sapiens
10 PLG 5340
Invitro Homo sapiens
11 COL2A1 1280
Affinity Capture-MS Homo sapiens
12 COL13A1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SPARC is involved
ECM proteoglycans TAS Reactome
Platelet degranulation TAS Reactome
Scavenging by Class H Receptors TAS Reactome

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