Gene description for PDGFA
Gene name	platelet-derived growth factor alpha polypeptide
Gene symbol	PDGFA
Other names/aliases	PDGF-A PDGF1
Species	Homo sapiens
Database cross references - PDGFA
ExoCarta	ExoCarta_5154
Entrez Gene	5154
HGNC	8799
MIM	173430
UniProt	P04085
PDGFA identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for PDGFA

Molecular Function     protein binding GO:0005515 IPI     platelet-derived growth factor receptor binding GO:0005161 IPI     protein homodimerization activity GO:0042803 IDA     platelet-derived growth factor binding GO:0048407 IPI     growth factor activity GO:0008083 IDA     protein heterodimerization activity GO:0046982 IPI     collagen binding GO:0005518 IDA Biological Process     response to hypoxia GO:0001666 IEA     positive regulation of mesenchymal cell proliferation GO:0002053 ISS     positive regulation of protein kinase B signaling GO:0051897 IDA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     cell activation GO:0001775 TAS     response to wounding GO:0009611 IDA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     regulation of DNA biosynthetic process GO:2000278 IDA     regulation of peptidyl-tyrosine phosphorylation GO:0050730 ISS     actin cytoskeleton organization GO:0030036 ISS     positive regulation of DNA replication GO:0045740 IDA     inner ear development GO:0048839 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     negative regulation of phosphatidylinositol biosynthetic process GO:0010512 IDA     regulation of glomerular mesangial cell proliferation GO:0072124 IDA     positive regulation of cell division GO:0051781 IEA     platelet-derived growth factor receptor signaling pathway GO:0048008 IDA     negative regulation of platelet activation GO:0010544 IDA     lung alveolus development GO:0048286 ISS     embryonic lung development GO:1990401 ISS     regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling GO:0060683 ISS     phosphatidylinositol-mediated signaling GO:0048015 TAS     response to drug GO:0042493 IEA     blood coagulation GO:0007596 TAS     transforming growth factor beta receptor signaling pathway GO:0007179 IEA     response to retinoic acid GO:0032526 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     cell-cell signaling GO:0007267 TAS     skin development GO:0043588 ISS     negative chemotaxis GO:0050919 IDA     positive regulation of MAPK cascade GO:0043410 IMP     angiogenesis GO:0001525 ISS     innate immune response GO:0045087 TAS     platelet activation GO:0030168 TAS     platelet degranulation GO:0002576 TAS     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA     cell projection assembly GO:0030031 ISS     regulation of smooth muscle cell migration GO:0014910 IDA     extracellular matrix organization GO:0030198 TAS     positive regulation of cell proliferation GO:0008284 IDA     positive regulation of MAP kinase activity GO:0043406 IDA     positive regulation of cell migration GO:0030335 IDA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     positive regulation of fibroblast proliferation GO:0048146 IDA     regulation of actin cytoskeleton organization GO:0032956 TAS     positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 IDA     response to inorganic substance GO:0010035 IEA     hair follicle development GO:0001942 ISS     positive regulation of protein autophosphorylation GO:0031954 IDA     response to estradiol GO:0032355 IEA     organ morphogenesis GO:0009887 ISS     wound healing GO:0042060 TAS Subcellular Localization     microvillus GO:0005902 ISS     extracellular space GO:0005615 IDA     cell surface GO:0009986 IDA     Golgi membrane GO:0000139 TAS     platelet alpha granule lumen GO:0031093 TAS     endoplasmic reticulum lumen GO:0005788 TAS     extracellular region GO:0005576 TAS