Gene description for ADAMTS1
Gene name ADAM metallopeptidase with thrombospondin type 1 motif, 1
Gene symbol ADAMTS1
Other names/aliases C3-C5
METH1
Species Homo sapiens
 Database cross references - ADAMTS1
ExoCarta ExoCarta_9510
Vesiclepedia VP_9510
Entrez Gene 9510
HGNC 217
MIM 605174
UniProt Q9UHI8  
 ADAMTS1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Prostate cancer cells 22723089    
 Gene ontology annotations for ADAMTS1
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 IDA
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
    metallopeptidase activity GO:0008237 TAS
    zinc ion binding GO:0008270 IEA
Biological Process
    ovulation from ovarian follicle GO:0001542 IEA
    kidney development GO:0001822 IEA
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IEA
    integrin-mediated signaling pathway GO:0007229 TAS
    negative regulation of cell population proliferation GO:0008285 TAS
    negative regulation of angiogenesis GO:0016525 IDA
    extracellular matrix organization GO:0030198 IBA
    heart trabecula formation GO:0060347 IEA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IGI
    positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IGI
    positive regulation of vascular associated smooth muscle cell migration GO:1904754 IGI
Subcellular Localization
    extracellular region GO:0005576 IEA
    basement membrane GO:0005604 IEA
    extracellular matrix GO:0031012 IBA
    cytoplasmic vesicle GO:0031410 IEA
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified ADAMTS1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 143
MISEV standards
EM
Biophysical techniques
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
HSP90B1
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for ADAMTS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPP7 143098
Affinity Capture-MS Homo sapiens
2 KLK2  
Affinity Capture-MS Homo sapiens
3 CCL3  
Affinity Capture-MS Homo sapiens
4 ADAMTS7  
Affinity Capture-MS Homo sapiens
5 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZMYND19  
Affinity Capture-MS Homo sapiens
7 NPC2 10577
Affinity Capture-MS Homo sapiens
8 LRP4 4038
Affinity Capture-MS Homo sapiens
9 CCL3L1  
Affinity Capture-MS Homo sapiens
10 ADAM32  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ABT1 29777
Affinity Capture-MS Homo sapiens
12 RANBP10 57610
Affinity Capture-MS Homo sapiens
13 CHD9 80205
Affinity Capture-MS Homo sapiens
14 NOTCH2 4853
Affinity Capture-MS Homo sapiens
15 GID4  
Affinity Capture-MS Homo sapiens
16 B3GALTL 145173
Affinity Capture-MS Homo sapiens
17 IFNA8  
Affinity Capture-MS Homo sapiens
18 KRTAP10-8  
Two-hybrid Homo sapiens
19 MISP 126353
Affinity Capture-MS Homo sapiens
20 IGFBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DLG1 1739
Affinity Capture-MS Homo sapiens
22 PDGFRA 5156
Affinity Capture-MS Homo sapiens
23 TUBB8 347688
Affinity Capture-MS Homo sapiens
24 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PRSS50  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CUL3 8452
Affinity Capture-MS Homo sapiens
27 VEGFA 7422
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
28 BRD2  
Affinity Capture-MS Homo sapiens
29 ERBB2IP 55914
Affinity Capture-MS Homo sapiens
30 SNX18 112574
Affinity Capture-MS Homo sapiens
31 RMND5B  
Affinity Capture-MS Homo sapiens
32 CELA3B  
Affinity Capture-MS Homo sapiens
33 ARMC8 25852
Affinity Capture-MS Homo sapiens
34 USP17L9P  
Affinity Capture-MS Homo sapiens
35 A2M 2
Affinity Capture-Western Homo sapiens
36 YPEL5 51646
Affinity Capture-MS Homo sapiens
37 DCAF6 55827
Affinity Capture-MS Homo sapiens
38 ERP44 23071
Affinity Capture-MS Homo sapiens
39 HPX 3263
Affinity Capture-MS Homo sapiens
40 IFNA5  
Affinity Capture-MS Homo sapiens
41 RANBP9 10048
Affinity Capture-MS Homo sapiens
42 CEP250 11190
Affinity Capture-MS Homo sapiens
43 CER1  
Affinity Capture-MS Homo sapiens
44 HPN  
Affinity Capture-MS Homo sapiens
45 GID8 54994
Affinity Capture-MS Homo sapiens
46 UBA5 79876
Affinity Capture-MS Homo sapiens
47 C1QTNF7  
Affinity Capture-MS Homo sapiens
48 TRIM21 6737
Affinity Capture-MS Homo sapiens
49 TIGD5  
Affinity Capture-MS Homo sapiens
50 HSPA5 3309
Affinity Capture-MS Homo sapiens
51 KRT40  
Two-hybrid Homo sapiens
52 PSMF1 9491
Affinity Capture-MS Homo sapiens
53 RMND5A 64795
Affinity Capture-MS Homo sapiens
54 ARRDC3 57561
Affinity Capture-MS Homo sapiens
55 LIN7C 55327
Affinity Capture-MS Homo sapiens
56 CHD8 57680
Affinity Capture-MS Homo sapiens
57 DDRGK1 65992
Affinity Capture-MS Homo sapiens
58 WDR26 80232
Affinity Capture-MS Homo sapiens
59 NAPSA 9476
Affinity Capture-MS Homo sapiens
60 ST14 6768
Affinity Capture-MS Homo sapiens
61 BMP1 649
Affinity Capture-MS Homo sapiens
62 CYR61 3491
Affinity Capture-MS Homo sapiens
63 MKLN1  
Affinity Capture-MS Homo sapiens
64 CBWD1 55871
Affinity Capture-MS Homo sapiens
65 IFNA21  
Affinity Capture-MS Homo sapiens
66 FBXO11  
Affinity Capture-MS Homo sapiens
67 PLA2G12B  
Affinity Capture-MS Homo sapiens
68 TMPRSS13  
Affinity Capture-MS Homo sapiens
69 MAEA 10296
Affinity Capture-MS Homo sapiens
70 ESF1 51575
Affinity Capture-MS Homo sapiens
71 PLA2G10  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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