Gene description for ADAMTS1
Gene name ADAM metallopeptidase with thrombospondin type 1 motif, 1
Gene symbol ADAMTS1
Other names/aliases C3-C5
METH1
Species Homo sapiens
 Database cross references - ADAMTS1
ExoCarta ExoCarta_9510
Entrez Gene 9510
HGNC 217
MIM 605174
UniProt Q9UHI8  
 ADAMTS1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 22723089    
 Gene ontology annotations for ADAMTS1
Molecular Function
    metallopeptidase activity GO:0008237 TAS
    heparin binding GO:0008201 IEA
    metalloendopeptidase activity GO:0004222 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    integrin-mediated signaling pathway GO:0007229 TAS
    negative regulation of cell proliferation GO:0008285 TAS
    ovulation from ovarian follicle GO:0001542 IEA
    kidney development GO:0001822 IEA
    proteolysis GO:0006508 IEA
    heart trabecula formation GO:0060347 IEA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IEA
    cytoplasm GO:0005737 IDA
    basement membrane GO:0005604 IEA
 Experiment description of studies that identified ADAMTS1 in exosomes
1
Experiment ID 143
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|HSP90|RAB5
EV Cytosolic markers
✔
LAMP2|CD9
EV Membrane markers
✔
HSP90B1
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for ADAMTS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 A2M 2
Affinity Capture-Western Homo sapiens
2 VEGF  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which ADAMTS1 is involved
PathwayEvidenceSource
Degradation of the extracellular matrix TAS Reactome
O-glycosylation of TSR domain-containing proteins TAS Reactome





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