Gene description for DCAF6
Gene name DDB1 and CUL4 associated factor 6
Gene symbol DCAF6
Other names/aliases 1200006M05Rik
ARCAP
IQWD1
MSTP055
NRIP
PC326
Species Homo sapiens
 Database cross references - DCAF6
ExoCarta ExoCarta_55827
Vesiclepedia VP_55827
Entrez Gene 55827
HGNC 30002
MIM 610494
UniProt Q58WW2  
 DCAF6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DCAF6
Molecular Function
    protein binding GO:0005515 IPI
    nuclear receptor coactivator activity GO:0030374 IBA
    nuclear receptor coactivator activity GO:0030374 IDA
Biological Process
    protein ubiquitination GO:0016567 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    focal adhesion GO:0005925 IDA
    Cul4-RING E3 ubiquitin ligase complex GO:0080008 IBA
    Cul4-RING E3 ubiquitin ligase complex GO:0080008 IDA
 Experiment description of studies that identified DCAF6 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DCAF6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PFDN1 5201
Affinity Capture-MS Homo sapiens
2 WDFY3 23001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 KPNA1 3836
Co-fractionation Homo sapiens
4 HS2ST1 9653
Affinity Capture-MS Homo sapiens
5 LYZL6  
Affinity Capture-MS Homo sapiens
6 PNOC  
Affinity Capture-MS Homo sapiens
7 MYL10 93408
Affinity Capture-MS Homo sapiens
8 LYPD6B 130576
Affinity Capture-MS Homo sapiens
9 C1QTNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DQX1  
Affinity Capture-MS Homo sapiens
11 SNX27 81609
Affinity Capture-MS Homo sapiens
12 CABP2  
Affinity Capture-MS Homo sapiens
13 CA6 765
Affinity Capture-MS Homo sapiens
14 GPS1 2873
Affinity Capture-MS Homo sapiens
15 COPS2 9318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 YAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 VPS28 51160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LOXL4 84171
Affinity Capture-MS Homo sapiens
19 KRT33B 3884
Affinity Capture-MS Homo sapiens
20 ITLN1 55600
Affinity Capture-MS Homo sapiens
21 MYO5C 55930
Affinity Capture-MS Homo sapiens
22 SP1  
Affinity Capture-Western Homo sapiens
23 ARFGAP2 84364
Affinity Capture-MS Homo sapiens
24 FAHD2B  
Affinity Capture-MS Homo sapiens
25 NFKBIA  
Affinity Capture-MS Homo sapiens
26 B3GNT3 10331
Affinity Capture-MS Homo sapiens
27 COPS8 10920
Affinity Capture-MS Homo sapiens
28 MAGEA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CABP4  
Affinity Capture-MS Homo sapiens
30 MDFI  
Two-hybrid Homo sapiens
31 NR3C1 2908
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
32 USP9X 8239
Co-fractionation Homo sapiens
33 TNNC2  
Affinity Capture-MS Homo sapiens
34 TRIM55  
Two-hybrid Homo sapiens
35 Ddb1 13194
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
36 PLA2G2D  
Affinity Capture-MS Homo sapiens
37 BMP15 9210
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 FMNL3 91010
Affinity Capture-MS Homo sapiens
39 SCG2  
Affinity Capture-MS Homo sapiens
40 CTSO  
Affinity Capture-MS Homo sapiens
41 NXF1 10482
Affinity Capture-RNA Homo sapiens
42 CUL4B 8450
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
43 DAB2 1601
Affinity Capture-MS Homo sapiens
44 MSMB  
Affinity Capture-MS Homo sapiens
45 ACACA 31
Co-fractionation Homo sapiens
46 DCAF6 55827
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 C10orf88  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ING1  
Affinity Capture-MS Homo sapiens
49 DDA1  
Affinity Capture-MS Homo sapiens
50 MOV10 4343
Affinity Capture-RNA Homo sapiens
51 CALCA  
Affinity Capture-MS Homo sapiens
52 ATP6V1G1 9550
Affinity Capture-MS Homo sapiens
53 Atm  
Affinity Capture-MS Mus musculus
54 EEF1D 1936
Affinity Capture-MS Homo sapiens
55 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
56 VARS 7407
Co-fractionation Homo sapiens
57 MAGEA4 4103
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 TRIM63  
Two-hybrid Homo sapiens
59 FAM46A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 NR2E1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 PIH1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 DDB1 1642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
63 CALN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 AKAP7 9465
Affinity Capture-MS Homo sapiens
65 COPS3 8533
Affinity Capture-MS Homo sapiens
66 AR 367
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
67 BRPF3  
Affinity Capture-MS Homo sapiens
68 GALNS 2588
Affinity Capture-MS Homo sapiens
69 PCSK1  
Affinity Capture-MS Homo sapiens
70 DNAJB1 3337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 SRP14 6727
Affinity Capture-MS Homo sapiens
72 UCK2 7371
Affinity Capture-MS Homo sapiens
73 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
74 EIF3H 8667
Co-fractionation Homo sapiens
75 CDK4 1019
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DCAF6 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





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