Gene description for FMNL3
Gene name formin-like 3
Gene symbol FMNL3
Other names/aliases FHOD3
FRL2
WBP-3
WBP3
Species Homo sapiens
 Database cross references - FMNL3
ExoCarta ExoCarta_91010
Entrez Gene 91010
HGNC 23698
MIM 616288
UniProt Q8IVF7  
 FMNL3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FMNL3
Molecular Function
    actin binding GO:0003779 IEA
    Rho GTPase binding GO:0017048 IEA
    GTPase activating protein binding GO:0032794 ISS
Biological Process
    cytoskeleton organization GO:0007010 IMP
    regulation of cell shape GO:0008360 IMP
    cell migration GO:0016477 IMP
    actin cytoskeleton organization GO:0030036 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified FMNL3 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FMNL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRPF40A 55660
Far Western Homo sapiens
View the network image/svg+xml
 Pathways in which FMNL3 is involved
PathwayEvidenceSource
RHO GTPases Activate Formins TAS Reactome





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