Gene description for SPECC1L
Gene name sperm antigen with calponin homology and coiled-coil domains 1-like
Gene symbol SPECC1L
Other names/aliases CYTSA
GBBB2
OBLFC1
Species Homo sapiens
 Database cross references - SPECC1L
ExoCarta ExoCarta_23384
Entrez Gene 23384
HGNC 29022
MIM 614140
UniProt Q69YQ0  
 SPECC1L identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SPECC1L
Biological Process
    cell migration GO:0016477 IEA
    cell division GO:0051301 IEA
    negative regulation of actin filament depolymerization GO:0030835 IEA
    negative regulation of microtubule depolymerization GO:0007026 IEA
    cell cycle GO:0007049 IEA
    actin cytoskeleton organization GO:0030036 IEA
Subcellular Localization
    spindle GO:0005819 IEA
    filamentous actin GO:0031941 IEA
    cytoplasm GO:0005737 IEA
    gap junction GO:0005921 IEA
    microtubule organizing center GO:0005815 IEA
 Experiment description of studies that identified SPECC1L in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SPECC1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SPECC1L is involved
No pathways found





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