Gene description for IRAK1BP1
Gene name interleukin-1 receptor-associated kinase 1 binding protein 1
Gene symbol IRAK1BP1
Other names/aliases AIP70
SIMPL
Species Homo sapiens
 Database cross references - IRAK1BP1
ExoCarta ExoCarta_134728
Vesiclepedia VP_134728
Entrez Gene 134728
HGNC 17368
MIM 615375
UniProt Q5VVH5  
 IRAK1BP1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for IRAK1BP1
Molecular Function
    protein binding GO:0005515 IPI
    signaling adaptor activity GO:0035591 IEA
Biological Process
    immune response GO:0006955 IEA
    canonical NF-kappaB signal transduction GO:0007249 ISS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified IRAK1BP1 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IRAK1BP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SCNM1  
Two-hybrid Homo sapiens
2 HERC1 8925
Affinity Capture-MS Homo sapiens
3 RIPPLY1  
Two-hybrid Homo sapiens
4 UFL1 23376
Two-hybrid Homo sapiens
5 PHF1  
Two-hybrid Homo sapiens
6 TFCP2 7024
Two-hybrid Homo sapiens
7 PRKAB2 5565
Two-hybrid Homo sapiens
8 IRAK1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 SPECC1L 23384
Affinity Capture-MS Homo sapiens
10 USP20  
Two-hybrid Homo sapiens
11 ZNF410  
Two-hybrid Homo sapiens
12 RIN3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IRAK1BP1 is involved
No pathways found





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