Gene description for PPFIBP2
Gene name PTPRF interacting protein, binding protein 2 (liprin beta 2)
Gene symbol PPFIBP2
Other names/aliases Cclp1
Species Homo sapiens
 Database cross references - PPFIBP2
ExoCarta ExoCarta_8495
Entrez Gene 8495
HGNC 9250
MIM 603142
UniProt Q8ND30  
 PPFIBP2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 25844599    
 Gene ontology annotations for PPFIBP2
Molecular Function
    molecular_function GO:0003674 ND
Subcellular Localization
    intracellular GO:0005622 TAS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified PPFIBP2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for PPFIBP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DTNB  
Two-hybrid Homo sapiens
2 PPFIA2 8499
Invitro Homo sapiens
3 SFN 2810
Affinity Capture-MS Homo sapiens
4 TSG101 7251
Two-hybrid Homo sapiens
5 PPFIA1 8500
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
6 PPFIA3 8541
Invitro Homo sapiens
7 PTPRC 5788
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which PPFIBP2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here