Gene description for PPFIBP2
Gene name
PTPRF interacting protein, binding protein 2 (liprin beta 2)
Gene symbol
PPFIBP2
Other names/aliases
Cclp1
Species
Homo sapiens
Database cross references - PPFIBP2
ExoCarta
ExoCarta_8495
Entrez Gene
8495
HGNC
9250
MIM
603142
UniProt
Q8ND30
PPFIBP2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells
25944692
Prostate cancer cells
25844599
Gene ontology annotations for PPFIBP2
Experiment description of studies that identified PPFIBP2 in exosomes
1
Experiment ID
224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25944692
Organism
Homo sapiens
Experiment description
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors
Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name
Oncotarget
Publication year
2015
Sample
Neuroblastoma cells
Sample name
SH-SY5Y
Isolation/purification methods
Differential centrifugation Ultracentrifugation OptiPrep density gradient
Flotation density
1.10 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry Western blotting
2
Experiment ID
275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25844599
Organism
Homo sapiens
Experiment description
Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors
Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name
Oncotarget
Publication year
2015
Sample
Prostate cancer cells
Sample name
DU145 - Docetaxel sensitive
Isolation/purification methods
Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.12-1.19 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry/Flow cytometry/Western blotting
Protein-protein interactions for PPFIBP2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
DTNB
Two-hybrid
Homo sapiens
2
PPFIA2
8499
Invitro
Homo sapiens
3
SFN
2810
Affinity Capture-MS
Homo sapiens
4
TSG101
7251
Two-hybrid
Homo sapiens
5
PPFIA1
8500
Invitro
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
6
PPFIA3
8541
Invitro
Homo sapiens
7
PTPRC
5788
Invitro
Homo sapiens
View the network
image/svg+xml
Pathways in which PPFIBP2 is involved
No pathways found