Gene description for TRIP4
Gene name thyroid hormone receptor interactor 4
Gene symbol TRIP4
Other names/aliases ASC-1
ASC1
HsT17391
ZC2HC5
Species Homo sapiens
 Database cross references - TRIP4
ExoCarta ExoCarta_9325
Vesiclepedia VP_9325
Entrez Gene 9325
HGNC 12310
MIM 604501
UniProt Q15650  
 TRIP4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TRIP4
Molecular Function
    estrogen receptor binding GO:0030331 IPI
    ligand-dependent nuclear receptor binding GO:0016922 IDA
    zinc ion binding GO:0008270 IEA
    protease binding GO:0002020 IPI
    protein binding GO:0005515 IPI
    ubiquitin-like protein ligase binding GO:0044389 IPI
    transcription coactivator activity GO:0003713 IMP
    histone acetyltransferase binding GO:0035035 IPI
Biological Process
    toxin transport GO:1901998 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    intracellular estrogen receptor signaling pathway GO:0030520 IDA
    transcription from RNA polymerase II promoter GO:0006366 TAS
Subcellular Localization
    cytosol GO:0005829 IEA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    microtubule organizing center GO:0005815 IEA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified TRIP4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRIP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NFKB1 4790
Invitro Homo sapiens
2 SHD  
Reconstituted Complex Homo sapiens
3 ESR1  
Reconstituted Complex Homo sapiens
4 RELA 5970
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
5 SRC 6714
Affinity Capture-Western Homo sapiens
6 Thrb  
Two-hybrid Rattus norvegicus
7 JUN 3725
Invivo Homo sapiens
8 RARA 5914
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
9 ASCC3 10973
Invivo Homo sapiens
Two-hybrid Homo sapiens
10 CREBBP  
Reconstituted Complex Homo sapiens
11 RXRA 6256
Affinity Capture-MS Homo sapiens
12 THRB 7068
Reconstituted Complex Homo sapiens
13 NCOA1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 EP300 2033
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRIP4 is involved
No pathways found





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