Gene description for RPL10L
Gene name ribosomal protein L10-like
Gene symbol RPL10L
Other names/aliases RPL10_5_1358
Species Homo sapiens
 Database cross references - RPL10L
ExoCarta ExoCarta_140801
Vesiclepedia VP_140801
Entrez Gene 140801
HGNC 17976
UniProt Q96L21  
 RPL10L identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RPL10L
Molecular Function
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 IDA
Biological Process
    ribosomal large subunit assembly GO:0000027 ISS
    translation GO:0006412 IBA
    male meiosis I GO:0007141 IBA
    male meiosis I GO:0007141 ISS
    spermatogenesis GO:0007283 IBA
    spermatogenesis GO:0007283 IEP
    spermatogenesis GO:0007283 IMP
    cell differentiation GO:0030154 IEA
Subcellular Localization
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 IDA
    ribosome GO:0005840 IDA
    membrane GO:0016020 HDA
    cytosolic large ribosomal subunit GO:0022625 IBA
    cytosolic large ribosomal subunit GO:0022625 IDA
    cytosolic large ribosomal subunit GO:0022625 NAS
 Experiment description of studies that identified RPL10L in exosomes
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RPL10L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
2 CEMIP 57214
Affinity Capture-MS Homo sapiens
3 SPRTN  
Affinity Capture-MS Homo sapiens
4 PCK1 5105
Affinity Capture-MS Homo sapiens
5 RPS3A 6189
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
6 RPL30 6156
Co-fractionation Homo sapiens
7 RPA2 6118
Affinity Capture-MS Homo sapiens
8 RPL37A 6168
Co-fractionation Homo sapiens
9 RPS19 6223
Co-fractionation Homo sapiens
10 RPL10 6134
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
11 RPL15 6138
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
12 RPL14 9045
Co-fractionation Homo sapiens
13 CAND1 55832
Affinity Capture-MS Homo sapiens
14 RPS3 6188
Co-fractionation Homo sapiens
15 USP36  
Affinity Capture-MS Homo sapiens
16 CHCHD4  
Co-fractionation Homo sapiens
17 RPL10A 4736
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
18 PRC1 9055
Affinity Capture-MS Homo sapiens
19 KIF23 9493
Affinity Capture-MS Homo sapiens
20 MCM2 4171
Affinity Capture-MS Homo sapiens
21 COPS5 10987
Affinity Capture-MS Homo sapiens
22 FBXW7  
Affinity Capture-MS Homo sapiens
23 RPL24 6152
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
24 NPM1 4869
Co-fractionation Homo sapiens
25 CUL4A 8451
Affinity Capture-MS Homo sapiens
26 CUL1 8454
Affinity Capture-MS Homo sapiens
27 RPS11 6205
Co-fractionation Homo sapiens
28 EEF1A1 1915
Co-fractionation Homo sapiens
29 KIF14 9928
Affinity Capture-MS Homo sapiens
30 RPS23 6228
Co-fractionation Homo sapiens
31 RPL27 6155
Co-fractionation Homo sapiens
32 RPL9 6133
Co-fractionation Homo sapiens
33 RPL4 6124
Co-fractionation Homo sapiens
34 RPS10 6204
Co-fractionation Homo sapiens
35 RPL5 6125
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
36 RPL18A 6142
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
37 CHMP4B 128866
Affinity Capture-MS Homo sapiens
38 RPL31 6160
Co-fractionation Homo sapiens
39 RPS7 6201
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
40 RPL36 25873
Co-fractionation Homo sapiens
41 RPL27A 6157
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
42 RPLP0 6175
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
43 CEP76  
Affinity Capture-MS Homo sapiens
44 RPLP0P6 220717
Co-fractionation Homo sapiens
45 MAGEB2 4113
Affinity Capture-MS Homo sapiens
46 RPS15A 6210
Co-fractionation Homo sapiens
47 RPL11 6135
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
48 ANLN 54443
Affinity Capture-MS Homo sapiens
49 RPL7A 6130
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
50 RPS2 6187
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
51 KIF20A 10112
Affinity Capture-MS Homo sapiens
52 ECT2 1894
Affinity Capture-MS Homo sapiens
53 RPL35 11224
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
54 EEF2 1938
Co-fractionation Homo sapiens
55 RPS6 6194
Co-fractionation Homo sapiens
56 RPL21 6144
Co-fractionation Homo sapiens
57 RPL3 6122
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
58 ARHGEF17 9828
Affinity Capture-MS Homo sapiens
59 AURKB 9212
Affinity Capture-MS Homo sapiens
60 CDK2 1017
Affinity Capture-MS Homo sapiens
61 RPA3 6119
Affinity Capture-MS Homo sapiens
62 RPS13 6207
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
63 RPS14 6208
Co-fractionation Homo sapiens
64 Stard13  
Affinity Capture-MS Mus musculus
65 RPL12 6136
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
66 RPL22 6146
Co-fractionation Homo sapiens
67 RPL18 6141
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
68 TUBB7P 56604
Co-fractionation Homo sapiens
69 BKRF1  
Affinity Capture-MS
70 RPL7 6129
Co-fractionation Homo sapiens
71 RPS16 6217
Co-fractionation Homo sapiens
72 RPL19 6143
Co-fractionation Homo sapiens
73 RPS27A 6233
Co-fractionation Homo sapiens
74 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
75 RPS25 6230
Co-fractionation Homo sapiens
76 SLC25A6 293
Co-fractionation Homo sapiens
77 TP53 7157
Affinity Capture-MS Homo sapiens
78 RPL6 6128
Co-fractionation Homo sapiens
79 TUBG1 7283
Affinity Capture-MS Homo sapiens
80 ZNF746  
Affinity Capture-MS Homo sapiens
81 RPA1 6117
Affinity Capture-MS Homo sapiens
82 RPS21 6227
Co-fractionation Homo sapiens
83 RPS12 6206
Co-fractionation Homo sapiens
84 RPS4X 6191
Co-fractionation Homo sapiens
85 RPS15 6209
Co-fractionation Homo sapiens
86 S100A10 6281
Co-fractionation Homo sapiens
87 RPS5 6193
Co-fractionation Homo sapiens
88 RPS26 6231
Co-fractionation Homo sapiens
89 RPS28 6234
Co-fractionation Homo sapiens
90 RPL38 6169
Co-fractionation Homo sapiens
91 RPS24 6229
Co-fractionation Homo sapiens
92 MOV10 4343
Co-fractionation Homo sapiens
93 SLC25A4 291
Co-fractionation Homo sapiens
94 TRIP4 9325
Affinity Capture-MS Homo sapiens
95 RPL23 9349
Co-fractionation Homo sapiens
96 RPS8 6202
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
97 RPL8 6132
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
98 ATP6V0A2 23545
Co-fractionation Homo sapiens
99 RPL23A 6147
Co-fractionation Homo sapiens
100 HNRNPU 3192
Co-fractionation Homo sapiens
101 RPL17 6139
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which RPL10L is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Cap-dependent Translation Initiation TAS Reactome
Cellular response to starvation IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Eukaryotic Translation Elongation IEA Reactome
Eukaryotic Translation Initiation TAS Reactome
Eukaryotic Translation Termination IEA Reactome
Formation of a pool of free 40S subunits TAS Reactome
GTP hydrolysis and joining of the 60S ribosomal subunit TAS Reactome
Infectious disease TAS Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
L13a-mediated translational silencing of Ceruloplasmin expression TAS Reactome
Major pathway of rRNA processing in the nucleolus and cytosol TAS Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Nervous system development IEA Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TAS Reactome
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) TAS Reactome
Nonsense-Mediated Decay (NMD) TAS Reactome
Peptide chain elongation IEA Reactome
Regulation of expression of SLITs and ROBOs IEA Reactome
Response of EIF2AK4 (GCN2) to amino acid deficiency IEA Reactome
rRNA processing TAS Reactome
rRNA processing in the nucleus and cytosol TAS Reactome
Selenoamino acid metabolism IEA Reactome
Selenocysteine synthesis IEA Reactome
Signaling by ROBO receptors IEA Reactome
SRP-dependent cotranslational protein targeting to membrane IEA Reactome
SRP-dependent cotranslational protein targeting to membrane TAS Reactome
Translation TAS Reactome
Translation IEA Reactome
Viral Infection Pathways TAS Reactome
Viral mRNA Translation TAS Reactome





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