Gene description for MED24
Gene name mediator complex subunit 24
Gene symbol MED24
Other names/aliases ARC100
CRSP100
CRSP4
DRIP100
THRAP4
TRAP100
Species Homo sapiens
 Database cross references - MED24
ExoCarta ExoCarta_9862
Vesiclepedia VP_9862
Entrez Gene 9862
HGNC 22963
MIM 607000
UniProt O75448  
 MED24 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MED24
Molecular Function
    vitamin D receptor binding GO:0042809 NAS
    protein binding GO:0005515 IPI
    thyroid hormone receptor binding GO:0046966 IDA
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 NAS
    receptor activity GO:0004872 IDA
    transcription cofactor activity GO:0003712 IDA
    RNA polymerase II transcription cofactor activity GO:0001104 IDA
    histone acetyltransferase activity GO:0004402 IEA
Biological Process
    stem cell maintenance GO:0019827 IEA
    histone acetylation GO:0016573 IEA
    intracellular steroid hormone receptor signaling pathway GO:0030518 IDA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IDA
    protein heterooligomerization GO:0051291 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    androgen receptor signaling pathway GO:0030521 IDA
    gene expression GO:0010467 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    mediator complex GO:0016592 NAS
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified MED24 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MED24
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPARG 5468
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
2 ESR1  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 THRA  
Affinity Capture-Western Homo sapiens
4 MED9  
Affinity Capture-MS Homo sapiens
5 VDR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TRG20  
Affinity Capture-MS Homo sapiens
7 IXL  
Affinity Capture-MS Homo sapiens
8 MED28  
Affinity Capture-MS Homo sapiens
9 PPARA  
Invitro Homo sapiens
10 RXRA 6256
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
11 CDK8 1024
Affinity Capture-MS Homo sapiens
12 CRSP7  
Affinity Capture-MS Homo sapiens
13 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
14 MED19  
Affinity Capture-MS Homo sapiens
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