Gene description for ASCC1
Gene name activating signal cointegrator 1 complex subunit 1
Gene symbol ASCC1
Other names/aliases ASC1p50
CGI-18
p50
Species Homo sapiens
 Database cross references - ASCC1
ExoCarta ExoCarta_51008
Entrez Gene 51008
HGNC 24268
MIM 614215
UniProt Q8N9N2  
 ASCC1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ASCC1
Molecular Function
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IDA
    transcription, DNA-templated GO:0006351 IEA
    DNA dealkylation involved in DNA repair GO:0006307 TAS
    DNA repair GO:0006281 TAS
Subcellular Localization
    transcription factor complex GO:0005667 IDA
    cytoplasm GO:0005737 IEA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified ASCC1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ASCC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCOA6  
Reconstituted Complex Homo sapiens
2 ASCC3 10973
Invivo Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ASCC1 is involved
PathwayEvidenceSource
ALKBH3 mediated reversal of alkylation damage TAS Reactome





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