Gene description for PPP1R12A
Gene name protein phosphatase 1, regulatory subunit 12A
Gene symbol PPP1R12A
Other names/aliases M130
MBS
MYPT1
Species Homo sapiens
 Database cross references - PPP1R12A
ExoCarta ExoCarta_4659
Vesiclepedia VP_4659
Entrez Gene 4659
HGNC 7618
MIM 602021
UniProt O14974  
 PPP1R12A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
T lymphocytes 34108659    
 Gene ontology annotations for PPP1R12A
Molecular Function
    enzyme inhibitor activity GO:0004857 IBA
    enzyme inhibitor activity GO:0004857 IDA
    protein binding GO:0005515 IPI
    myosin phosphatase regulator activity GO:0017020 IBA
    phosphatase regulator activity GO:0019208 IDA
    phosphatase regulator activity GO:0019208 IMP
    protein kinase binding GO:0019901 IPI
    14-3-3 protein binding GO:0071889 IDA
Biological Process
    mitotic cell cycle GO:0000278 IMP
    protein dephosphorylation GO:0006470 IMP
    centrosome cycle GO:0007098 IMP
    signal transduction GO:0007165 IEA
    regulation of cell adhesion GO:0030155 IDA
    negative regulation of catalytic activity GO:0043086 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    regulation of nucleocytoplasmic transport GO:0046822 IEA
    neuron projection morphogenesis GO:0048812 IBA
    cellular response to xenobiotic stimulus GO:0071466 IEA
    regulation of establishment of endothelial barrier GO:1903140 IMP
Subcellular Localization
    kinetochore GO:0000776 IDA
    stress fiber GO:0001725 IEA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    focal adhesion GO:0005925 HDA
    actin cytoskeleton GO:0015629 IDA
    Z disc GO:0030018 IBA
    Z disc GO:0030018 ISS
    A band GO:0031672 IBA
    A band GO:0031672 ISS
    contractile muscle fiber GO:0043292 IDA
    PTW/PP1 phosphatase complex GO:0072357 IDA
 Experiment description of studies that identified PPP1R12A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
10
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
22
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
29
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for PPP1R12A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL27 6155
Cross-Linking-MS (XL-MS) Homo sapiens
2 CDC14B 8555
Affinity Capture-MS Homo sapiens
3 ACTR2 10097
Affinity Capture-MS Homo sapiens
4 ARHGEF25 115557
Affinity Capture-MS Homo sapiens
5 LUZP4  
Affinity Capture-MS Homo sapiens
6 METTL17  
Affinity Capture-MS Homo sapiens
7 ISG15 9636
Affinity Capture-MS Homo sapiens
8 Cdk1 12534
Affinity Capture-MS Mus musculus
9 FMNL1 752
Affinity Capture-MS Homo sapiens
10 PPP1CB 5500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
11 HDAC2 3066
Co-fractionation Homo sapiens
12 MED17  
Affinity Capture-MS Homo sapiens
13 PAXIP1  
Affinity Capture-MS Homo sapiens
14 RPS3A 6189
Co-fractionation Homo sapiens
15 SIAH2 6478
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
16 CPOX 1371
Co-fractionation Homo sapiens
17 WDR82 80335
Co-fractionation Homo sapiens
18 PTBP1 5725
Co-fractionation Homo sapiens
19 ARPC2 10109
Co-fractionation Homo sapiens
20 PSMA4 5685
Co-fractionation Homo sapiens
21 PPP6R3 55291
Co-fractionation Homo sapiens
22 RPA2 6118
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
23 CRK 1398
Affinity Capture-MS Homo sapiens
24 HNRNPDL 9987
Co-fractionation Homo sapiens
25 FBXO25  
Affinity Capture-MS Homo sapiens
26 DBN1 1627
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
27 PACSIN2 11252
Affinity Capture-MS Homo sapiens
28 PPP1CC 5501
Co-fractionation Homo sapiens
29 RPS19 6223
Co-fractionation Homo sapiens
30 RNF38  
Affinity Capture-MS Homo sapiens
31 KIF20A 10112
Affinity Capture-MS Homo sapiens
32 TRDMT1  
Affinity Capture-MS Homo sapiens
33 HSP90AB1 3326
Co-fractionation Homo sapiens
34 IL16  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
35 TROVE2 6738
Co-fractionation Homo sapiens
36 Actb 11461
Affinity Capture-MS Mus musculus
37 SYDE2  
Affinity Capture-MS Homo sapiens
38 MILR1  
Affinity Capture-MS Homo sapiens
39 CORO6  
Affinity Capture-MS Homo sapiens
40 TRIB2 28951
Affinity Capture-MS Homo sapiens
41 COPS5 10987
Co-fractionation Homo sapiens
42 ANKRD50 57182
Affinity Capture-MS Homo sapiens
43 APEX1 328
Affinity Capture-RNA Homo sapiens
44 KIAA1429 25962
Affinity Capture-MS Homo sapiens
45 CAPZB 832
Affinity Capture-MS Homo sapiens
46 RUVBL1 8607
Co-fractionation Homo sapiens
47 Dync1h1 13424
Affinity Capture-MS Mus musculus
48 RDX 5962
Co-fractionation Homo sapiens
49 Trim69  
Affinity Capture-MS Mus musculus
50 KIF23 9493
Affinity Capture-Western Homo sapiens
51 GAGE5  
Affinity Capture-MS Homo sapiens
52 TUBA1C 84790
Co-fractionation Homo sapiens
53 ACTR3 10096
Co-fractionation Homo sapiens
54 GABBR1  
Affinity Capture-MS Homo sapiens
55 CALD1 800
Affinity Capture-MS Homo sapiens
56 TRIOBP 11078
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
57 ANKRD49  
Affinity Capture-MS Homo sapiens
58 Poc1b  
Affinity Capture-MS Mus musculus
59 PRC1 9055
Affinity Capture-MS Homo sapiens
60 IQGAP1 8826
Affinity Capture-MS Homo sapiens
61 NPM1 4869
Co-fractionation Homo sapiens
62 CALM3 808
Affinity Capture-MS Homo sapiens
63 SPECC1L 23384
Affinity Capture-MS Homo sapiens
64 YWHAG 7532
Affinity Capture-MS Homo sapiens
65 SMARCA4 6597
Co-fractionation Homo sapiens
66 SOST  
Affinity Capture-MS Homo sapiens
67 THRSP  
Affinity Capture-MS Homo sapiens
68 DYNLL1 8655
Affinity Capture-MS Homo sapiens
69 CES2 8824
Affinity Capture-MS Homo sapiens
70 TULP3 7289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 NUSAP1 51203
Co-fractionation Homo sapiens
72 YWHAH 7533
Affinity Capture-MS Homo sapiens
73 ATG16L1 55054
Affinity Capture-MS Homo sapiens
74 PHF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CUL1 8454
Co-fractionation Homo sapiens
76 SH3BGRL 6451
Affinity Capture-MS Homo sapiens
77 HSPA2 3306
Affinity Capture-MS Homo sapiens
78 SMARCB1 6598
Co-fractionation Homo sapiens
79 PLS3 5358
Co-fractionation Homo sapiens
80 Erh  
Affinity Capture-MS Mus musculus
81 OCLM  
Affinity Capture-MS Homo sapiens
82 RLIM 51132
Affinity Capture-MS Homo sapiens
83 Lima1  
Affinity Capture-MS Mus musculus
84 KIF14 9928
Affinity Capture-MS Homo sapiens
85 HSPA8 3312
Affinity Capture-MS Homo sapiens
86 TPT1 7178
Affinity Capture-MS Homo sapiens
87 COPS3 8533
Co-fractionation Homo sapiens
88 CHMP4C 92421
Affinity Capture-MS Homo sapiens
89 TOLLIP 54472
Proximity Label-MS Homo sapiens
90 PPP1CA 5499
Co-fractionation Homo sapiens
91 RHOA 387
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
92 MYO18A 399687
Affinity Capture-MS Homo sapiens
93 TUBA1B 10376
Co-fractionation Homo sapiens
94 VAV1 7409
Affinity Capture-MS Homo sapiens
95 EML4 27436
Co-fractionation Homo sapiens
96 CBX3 11335
Co-fractionation Homo sapiens
97 FKBP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 RAI14 26064
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
99 FNBP1 23048
Co-fractionation Homo sapiens
100 HSP90B1 7184
Cross-Linking-MS (XL-MS) Homo sapiens
101 SMARCC1 6599
Co-fractionation Homo sapiens
102 MAPRE1 22919
Affinity Capture-MS Homo sapiens
103 DDIT3 1649
Affinity Capture-MS Homo sapiens
104 CLTCL1 8218
Affinity Capture-MS Homo sapiens
105 AHNAK 79026
Cross-Linking-MS (XL-MS) Homo sapiens
106 POC1A  
Affinity Capture-MS Homo sapiens
107 PTP4A3  
Affinity Capture-MS Homo sapiens
108 HDAC7  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
109 DEK 7913
Co-fractionation Homo sapiens
110 CHMP4B 128866
Affinity Capture-MS Homo sapiens
111 SP110  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 YWHAE 7531
Affinity Capture-MS Homo sapiens
113 MYH9 4627
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
114 VCP 7415
Co-fractionation Homo sapiens
115 ACTN4 81
Affinity Capture-MS Homo sapiens
116 NTRK1 4914
Affinity Capture-MS Homo sapiens
117 CDKN3 1033
Biochemical Activity Homo sapiens
118 MALL  
Affinity Capture-MS Homo sapiens
119 EEF2 1938
Cross-Linking-MS (XL-MS) Homo sapiens
120 DNAJA1 3301
Co-fractionation Homo sapiens
121 GAPDH 2597
Co-fractionation Homo sapiens
122 BBS1 582
Affinity Capture-MS Homo sapiens
123 Calml3  
Affinity Capture-MS Mus musculus
124 ACTB 60
Proximity Label-MS Homo sapiens
125 TPP2 7174
Co-fractionation Homo sapiens
126 MYH10 4628
Co-fractionation Homo sapiens
127 Coro1c 23790
Affinity Capture-MS Mus musculus
128 IDH3G 3421
Co-fractionation Homo sapiens
129 LRRFIP1 9208
Co-fractionation Homo sapiens
130 PUS1 80324
Co-fractionation Homo sapiens
131 NCL 4691
Co-fractionation Homo sapiens
132 SETD7 80854
Biochemical Activity Homo sapiens
133 RYBP  
Affinity Capture-MS Homo sapiens
134 PPP1R12C 54776
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
135 TTLL12 23170
Co-fractionation Homo sapiens
136 SMARCC2 6601
Co-fractionation Homo sapiens
137 P3H1 64175
Co-fractionation Homo sapiens
138 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
139 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 TRIM21 6737
Affinity Capture-MS Homo sapiens
141 NEFM 4741
Cross-Linking-MS (XL-MS) Homo sapiens
142 HAP1  
Affinity Capture-MS Homo sapiens
143 FTH1 2495
Co-fractionation Homo sapiens
144 NUAK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 Stag2  
Affinity Capture-MS Mus musculus
146 BRF1  
Affinity Capture-MS Homo sapiens
147 ZBTB2 57621
Affinity Capture-MS Homo sapiens
148 GOLGA3 2802
Co-fractionation Homo sapiens
149 ASAH1 427
Co-fractionation Homo sapiens
150 TAF15 8148
Co-fractionation Homo sapiens
151 RABGGTA 5875
Affinity Capture-MS Homo sapiens
152 AHCY 191
Co-fractionation Homo sapiens
153 Myh9 17886
Affinity Capture-MS Mus musculus
154 STRN3 29966
Co-fractionation Homo sapiens
155 UPF1 5976
Co-fractionation Homo sapiens
156 AHCYL1 10768
Co-fractionation Homo sapiens
157 JPH3 57338
Affinity Capture-MS Homo sapiens
158 C9orf78 51759
Affinity Capture-MS Homo sapiens
159 USP15 9958
Co-fractionation Homo sapiens
160 BAG2 9532
Affinity Capture-MS Homo sapiens
161 ECT2 1894
Affinity Capture-MS Homo sapiens
162 ARHGAP11A  
Affinity Capture-MS Homo sapiens
163 UBE2L3 7332
Cross-Linking-MS (XL-MS) Homo sapiens
164 CTNNB1 1499
Affinity Capture-MS Homo sapiens
165 CTTN 2017
Affinity Capture-MS Homo sapiens
166 ERLEC1 27248
Affinity Capture-MS Homo sapiens
167 BPTF 2186
Co-fractionation Homo sapiens
168 BTF3 689
Affinity Capture-MS Homo sapiens
169 SMARCA5 8467
Co-fractionation Homo sapiens
170 TNPO3 23534
Co-fractionation Homo sapiens
171 OSGEP 55644
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
172 MYO19  
Affinity Capture-MS Homo sapiens
173 RNF138  
Affinity Capture-MS Homo sapiens
174 ATXN10 25814
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
175 USP47 55031
Co-fractionation Homo sapiens
176 NUAK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
177 UACA 55075
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
178 MYO5C 55930
Affinity Capture-MS Homo sapiens
179 MYO1C 4641
Affinity Capture-MS Homo sapiens
180 CDC42 998
Affinity Capture-MS Homo sapiens
181 CDK2 1017
Affinity Capture-MS Homo sapiens
182 Cep72  
Affinity Capture-MS Mus musculus
183 SYNPO 11346
Affinity Capture-MS Homo sapiens
184 FOS 2353
Affinity Capture-MS Homo sapiens
185 PSPC1 55269
Affinity Capture-MS Homo sapiens
186 Uso1 56041
Affinity Capture-MS Mus musculus
187 AHR 196
Affinity Capture-MS Homo sapiens
188 RPL35A 6165
Affinity Capture-MS Homo sapiens
189 HSPA1A 3303
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
190 JUNB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 PRPF40A 55660
Co-fractionation Homo sapiens
192 Haus3  
Affinity Capture-MS Mus musculus
193 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
194 FLII 2314
Co-fractionation Homo sapiens
195 CASR  
Affinity Capture-Western Homo sapiens
196 SIK2  
Affinity Capture-MS Homo sapiens
197 Ppp1cb 19046
Affinity Capture-MS Mus musculus
198 TSR1 55720
Co-fractionation Homo sapiens
199 2510003E04Rik  
Affinity Capture-MS Mus musculus
200 PFDN5 5204
Co-fractionation Homo sapiens
201 ZNF263  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 G3BP2 9908
Co-fractionation Homo sapiens
203 MRPL42  
Affinity Capture-MS Homo sapiens
204 ARRB2 409
Affinity Capture-MS Homo sapiens
205 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
206 Tmod3 50875
Affinity Capture-MS Mus musculus
207 MAGEF1  
Affinity Capture-MS Homo sapiens
208 RRBP1 6238
Co-fractionation Homo sapiens
209 ILF3 3609
Co-fractionation Homo sapiens
210 TP53 7157
Affinity Capture-MS Homo sapiens
211 CDK8 1024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 MACF1 23499
Co-fractionation Homo sapiens
213 RBM25 58517
Co-fractionation Homo sapiens
214 DNAJA2 10294
Co-fractionation Homo sapiens
215 CXCL6  
Affinity Capture-MS Homo sapiens
216 MRPS18C  
Affinity Capture-MS Homo sapiens
217 RPA1 6117
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
218 Myo1c 17913
Affinity Capture-MS Mus musculus
219 UBA52 7311
Affinity Capture-MS Homo sapiens
220 SEPT9 10801
Affinity Capture-MS Homo sapiens
221 PFDN1 5201
Co-fractionation Homo sapiens
222 CAPZA2 830
Affinity Capture-MS Homo sapiens
223 SH3BP5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
224 SMAD4  
Affinity Capture-MS Homo sapiens
225 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
226 CAPRIN1 4076
Co-fractionation Homo sapiens
227 CHD4 1108
Co-fractionation Homo sapiens
228 HNRNPA3 220988
Co-fractionation Homo sapiens
229 Sass6  
Affinity Capture-MS Mus musculus
230 EPB41L2 2037
Co-fractionation Homo sapiens
231 RABL6 55684
Co-fractionation Homo sapiens
232 AARSD1 80755
Co-fractionation Homo sapiens
233 WIF1 11197
Affinity Capture-MS Homo sapiens
234 Myh10 77579
Affinity Capture-MS Mus musculus
235 MPRIP 23164
Co-fractionation Homo sapiens
236 PHKA2 5256
Affinity Capture-MS Homo sapiens
237 XPO5 57510
Co-fractionation Homo sapiens
238 KDM1A 23028
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
239 CDV3 55573
Co-fractionation Homo sapiens
240 TMEM257  
Affinity Capture-MS Homo sapiens
241 LRRK2 120892
Affinity Capture-MS Homo sapiens
242 SNRNP70 6625
Co-fractionation Homo sapiens
243 HNRNPC 3183
Co-fractionation Homo sapiens
244 MND1  
Affinity Capture-MS Homo sapiens
245 FLNA 2316
Affinity Capture-MS Homo sapiens
246 PINK1  
Affinity Capture-MS Homo sapiens
247 SERPINB2 5055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
248 PLCD3 113026
Affinity Capture-MS Homo sapiens
249 RPRD1B 58490
Co-fractionation Homo sapiens
250 KRAS 3845
Negative Genetic Homo sapiens
251 TRIM47 91107
Co-fractionation Homo sapiens
252 TRPM2  
Affinity Capture-MS Homo sapiens
253 NSUN2 54888
Co-fractionation Homo sapiens
254 MYC  
Affinity Capture-MS Homo sapiens
255 UBA6 55236
Co-fractionation Homo sapiens
256 COPS4 51138
Co-fractionation Homo sapiens
257 Sept9  
Affinity Capture-MS Mus musculus
258 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
259 NUDT5 11164
Co-fractionation Homo sapiens
260 RCOR1  
Co-fractionation Homo sapiens
261 TUBB4B 10383
Co-fractionation Homo sapiens
262 RANBP2 5903
Co-fractionation Homo sapiens
263 NRD1 4898
Co-fractionation Homo sapiens
264 PRKG1 5592
Reconstituted Complex Homo sapiens
265 DYRK1A 1859
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here