Gene description for TRIB2
Gene name tribbles pseudokinase 2
Gene symbol TRIB2
Other names/aliases C5FW
GS3955
TRB2
Species Homo sapiens
 Database cross references - TRIB2
ExoCarta ExoCarta_28951
Vesiclepedia VP_28951
Entrez Gene 28951
HGNC 30809
MIM 609462
UniProt Q92519  
 TRIB2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TRIB2
Molecular Function
    nucleotide binding GO:0000166 ISS
    protein kinase activity GO:0004672 ISS
    protein kinase inhibitor activity GO:0004860 IEA
    protein binding GO:0005515 IPI
    mitogen-activated protein kinase kinase binding GO:0031434 IBA
    ubiquitin protein ligase binding GO:0031625 ISS
    ubiquitin-protein transferase regulator activity GO:0055106 ISS
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISS
Biological Process
    protein phosphorylation GO:0006468 ISS
    negative regulation of protein kinase activity GO:0006469 NAS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IBA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
    negative regulation of interleukin-10 production GO:0032693 IMP
    regulation of MAP kinase activity GO:0043405 ISS
    negative regulation of fat cell differentiation GO:0045599 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 ISS
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified TRIB2 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TRIB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCBP2 5094
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 CUL1 8454
Affinity Capture-Western Homo sapiens
3 BTRC 8945
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
4 UBQLN4 56893
Two-hybrid Homo sapiens
5 PARP1 142
Affinity Capture-MS Homo sapiens
6 TFAP4 7023
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RFWD2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
8 KIAA1217 56243
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ISCA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RPTOR 57521
Affinity Capture-MS Homo sapiens
11 PRMT6  
Two-hybrid Homo sapiens
12 SMURF1 57154
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 UBE2E1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CCDC33 80125
Affinity Capture-MS Homo sapiens
15 APP 351
Reconstituted Complex Homo sapiens
16 HSPA5 3309
Affinity Capture-MS Homo sapiens
17 POTEF 728378
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RPS6KB1 6198
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
20 STK40  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TRIM21 6737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 TRIB1 10221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 KCTD21 283219
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 HSPD1 3329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 DET1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 GSTA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 BDH2 56898
Affinity Capture-MS Homo sapiens
28 SLAMF7  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRIB2 is involved
No pathways found





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