Gene description for TRIB2
Gene name tribbles pseudokinase 2
Gene symbol TRIB2
Other names/aliases C5FW
GS3955
TRB2
Species Homo sapiens
 Database cross references - TRIB2
ExoCarta ExoCarta_28951
Entrez Gene 28951
HGNC 30809
MIM 609462
UniProt Q92519  
 TRIB2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TRIB2
Molecular Function
    ubiquitin protein ligase binding GO:0031625 ISS
    protein kinase inhibitor activity GO:0004860 IEA
    mitogen-activated protein kinase kinase binding GO:0031434 IBA
    transcription factor binding GO:0008134 ISS
    protein kinase activity GO:0004672 ISS
    nucleotide binding GO:0000166 ISS
    ubiquitin-protein transferase regulator activity GO:0055106 ISS
Biological Process
    negative regulation of protein kinase activity GO:0006469 NAS
    protein phosphorylation GO:0006468 ISS
    negative regulation of interleukin-10 biosynthetic process GO:0045081 IMP
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
    negative regulation of fat cell differentiation GO:0045599 ISS
    regulation of MAP kinase activity GO:0043405 ISS
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    cytoplasm GO:0005737 ISS
    nucleus GO:0005634 IBA
 Experiment description of studies that identified TRIB2 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TRIB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRIB2 is involved
No pathways found





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