Gene description for KCTD21
Gene name potassium channel tetramerization domain containing 21
Gene symbol KCTD21
Other names/aliases KCASH2
Species Homo sapiens
 Database cross references - KCTD21
ExoCarta ExoCarta_283219
Vesiclepedia VP_283219
Entrez Gene 283219
HGNC 27452
UniProt Q4G0X4  
 KCTD21 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for KCTD21
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    histone deacetylase binding GO:0042826 IBA
    histone deacetylase binding GO:0042826 IDA
    cullin family protein binding GO:0097602 IBA
    cullin family protein binding GO:0097602 IDA
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    protein ubiquitination GO:0016567 IEA
    negative regulation of smoothened signaling pathway GO:0045879 IDA
    protein homooligomerization GO:0051260 IEA
 Experiment description of studies that identified KCTD21 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KCTD21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP1A2 477
Affinity Capture-MS Homo sapiens
2 DUSP22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZMYND19  
Two-hybrid Homo sapiens
4 TIMM50 92609
Affinity Capture-MS Homo sapiens
5 MAD2L1 4085
Affinity Capture-MS Homo sapiens
6 LSM12 124801
Affinity Capture-MS Homo sapiens
7 LONRF1  
Two-hybrid Homo sapiens
8 RNF25 64320
Two-hybrid Homo sapiens
9 SOX2  
Affinity Capture-MS Homo sapiens
10 CUL3 8452
Affinity Capture-MS Homo sapiens
11 MRGBP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TNFAIP6 7130
Affinity Capture-MS Homo sapiens
13 ANKRD39  
Affinity Capture-MS Homo sapiens
14 TRIB2 28951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 C10orf91  
Affinity Capture-MS Homo sapiens
16 LILRB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 C22orf15  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
18 PPL 5493
Two-hybrid Homo sapiens
19 NMRK1  
Two-hybrid Homo sapiens
20 TRIM28 10155
Affinity Capture-MS Homo sapiens
21 WDYHV1  
Two-hybrid Homo sapiens
22 MAGED1 9500
Affinity Capture-MS Homo sapiens
23 UFM1 51569
Two-hybrid Homo sapiens
24 PIGR 5284
Affinity Capture-MS Homo sapiens
25 KCTD21 283219
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 KCTD15 79047
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
27 CRLF3 51379
Two-hybrid Homo sapiens
28 DOC2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 DNAJB11 51726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 WDFY1 57590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SEC61A1 29927
Affinity Capture-MS Homo sapiens
32 KLHL14 57565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KCTD21 is involved
No pathways found





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