Gene description for CRLF3
Gene name cytokine receptor-like factor 3
Gene symbol CRLF3
Other names/aliases CREME-9
CREME9
CRLM9
CYTOR4
FRWS
p48.2
Species Homo sapiens
 Database cross references - CRLF3
ExoCarta ExoCarta_51379
Entrez Gene 51379
HGNC 17177
MIM 614853
UniProt Q8IUI8  
 CRLF3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CRLF3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    positive regulation of cell cycle arrest GO:0071158 IDA
    negative regulation of cell growth GO:0030308 IDA
    positive regulation of JAK-STAT cascade GO:0046427 IDA
    G1/S transition of mitotic cell cycle GO:0000082 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified CRLF3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CRLF3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CRLF3 is involved
No pathways found





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