Gene description for ENPP6
Gene name ectonucleotide pyrophosphatase/phosphodiesterase 6
Gene symbol ENPP6
Other names/aliases NPP6
Species Homo sapiens
 Database cross references - ENPP6
ExoCarta ExoCarta_133121
Vesiclepedia VP_133121
Entrez Gene 133121
HGNC 23409
UniProt Q6UWR7  
 ENPP6 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ENPP6
Molecular Function
    protein binding GO:0005515 IPI
    phosphoric diester hydrolase activity GO:0008081 IDA
    glycerophosphodiester phosphodiesterase activity GO:0008889 IBA
    metal ion binding GO:0046872 IEA
    glycerophosphocholine cholinephosphodiesterase activity GO:0047390 EXP
    glycerophosphocholine cholinephosphodiesterase activity GO:0047390 IDA
Biological Process
    lipid metabolic process GO:0006629 IBA
    lipid metabolic process GO:0006629 IDA
    choline metabolic process GO:0019695 IBA
    choline metabolic process GO:0019695 IDA
    glycerophospholipid catabolic process GO:0046475 TAS
Subcellular Localization
    extracellular region GO:0005576 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified ENPP6 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ENPP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SACS 26278
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GNPAT 8443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 EMC3 55831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 EMC8 10328
Affinity Capture-MS Homo sapiens
5 CTPS2 56474
Affinity Capture-MS Homo sapiens
6 MKS1 54903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ND5 4540
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 OCRL 4952
Affinity Capture-MS Homo sapiens
10 SCAMP1 9522
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ASPH 444
Two-hybrid Homo sapiens
12 EMC7 56851
Affinity Capture-MS Homo sapiens
13 SLC26A6 65010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GLMN 11146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 NDUFB5 4711
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TOR4A 54863
Affinity Capture-MS Homo sapiens
17 VAMP3 9341
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 GLB1L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PTPN1 5770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 RUNDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RIPK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMTC3 160418
Affinity Capture-MS Homo sapiens
23 TRIM24  
Affinity Capture-MS Homo sapiens
24 AGTRAP 57085
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 NDUFB9 4715
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ZBTB33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MEX3B 84206
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 NDUFB3 4709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 NDUFB8 4714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 NDUFA7 4701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 C14orf80  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 IMPAD1 54928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DIAPH3 81624
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LMF2 91289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PIGS 94005
Affinity Capture-MS Homo sapiens
37 LMF1 64788
Affinity Capture-MS Homo sapiens
38 NUP85 79902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 STEAP3 55240
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CRLF3 51379
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TMEM206 55248
Affinity Capture-MS Homo sapiens
42 ALG9 79796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 NDUFB4 4710
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ENPP6 is involved
PathwayEvidenceSource
Glycerophospholipid catabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Phospholipid metabolism TAS Reactome
PI Metabolism TAS Reactome





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