Gene description for ENPP6
Gene name ectonucleotide pyrophosphatase/phosphodiesterase 6
Gene symbol ENPP6
Other names/aliases NPP6
Species Homo sapiens
 Database cross references - ENPP6
ExoCarta ExoCarta_133121
Entrez Gene 133121
HGNC 23409
UniProt Q6UWR7  
 ENPP6 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ENPP6
Molecular Function
    glycerophosphocholine cholinephosphodiesterase activity GO:0047390 IDA
    glycerophosphodiester phosphodiesterase activity GO:0008889 IEA
    phosphoric diester hydrolase activity GO:0008081 IDA
Biological Process
    choline metabolic process GO:0019695 IDA
    lipid catabolic process GO:0016042 IEA
    lipid metabolic process GO:0006629 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 IDA
    anchored component of membrane GO:0031225 IEA
    extracellular region GO:0005576 IDA
 Experiment description of studies that identified ENPP6 in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ENPP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ENPP6 is involved
No pathways found

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