Gene description for GLMN
Gene name glomulin, FKBP associated protein
Gene symbol GLMN
Other names/aliases FAP
FAP48
FAP68
FKBPAP
GLML
GVM
VMGLOM
Species Homo sapiens
 Database cross references - GLMN
ExoCarta ExoCarta_11146
Entrez Gene 11146
HGNC 14373
MIM 601749
UniProt Q92990  
 GLMN identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for GLMN
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-protein transferase inhibitor activity GO:0055105 IGI
    hepatocyte growth factor receptor binding GO:0005171 IPI
    ubiquitin protein ligase binding GO:0031625 IDA
Biological Process
    positive regulation of interleukin-2 biosynthetic process GO:0045086 IMP
    muscle cell differentiation GO:0042692 IMP
    neural tube closure GO:0001843 IEA
    regulation of gene expression, epigenetic GO:0040029 IMP
    negative regulation of T cell proliferation GO:0042130 IDA
    vasculogenesis GO:0001570 IMP
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IMP
    negative regulation of protein ubiquitination GO:0031397 IGI
    positive regulation of cytokine secretion GO:0050715 IMP
    positive regulation of phosphorylation GO:0042327 IDA
Subcellular Localization
    Cul4A-RING E3 ubiquitin ligase complex GO:0031464 IPI
    intracellular GO:0005622 NAS
    cullin-RING ubiquitin ligase complex GO:0031461 IPI
    Cul3-RING ubiquitin ligase complex GO:0031463 IPI
    Cul2-RING ubiquitin ligase complex GO:0031462 IPI
 Experiment description of studies that identified GLMN in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GLMN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MET 4233
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 FKBP1A 2280
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
3 FKBP4 2288
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GLMN is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here