Gene description for CDKN1B
Gene name	cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene symbol	CDKN1B
Other names/aliases	CDKN4 KIP1 MEN1B MEN4 P27KIP1
Species	Homo sapiens
Database cross references - CDKN1B
ExoCarta	ExoCarta_1027
Entrez Gene	1027
HGNC	1785
MIM	600778
UniProt	P46527
CDKN1B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for CDKN1B

Molecular Function     protein complex binding GO:0032403 IEA     protein binding GO:0005515 IPI     protein phosphatase binding GO:0019903 IPI     transforming growth factor beta receptor, cytoplasmic mediator activity GO:0005072 TAS     Hsp70 protein binding GO:0030544 IEA     cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 IDA     chaperone binding GO:0051087 IEA     cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 IEA Biological Process     negative regulation of kinase activity GO:0033673 IDA     positive regulation of microtubule polymerization GO:0031116 IEA     negative regulation of cell proliferation GO:0008285 IMP     negative regulation of apoptotic process GO:0043066 IEA     response to peptide hormone GO:0043434 IEA     inner ear development GO:0048839 IEA     response to amino acid GO:0043200 IEA     DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     autophagic cell death GO:0048102 IDA     phosphatidylinositol-mediated signaling GO:0048015 TAS     negative regulation of phosphorylation GO:0042326 IDA     cellular response to organic cyclic compound GO:0071407 IEA     small GTPase mediated signal transduction GO:0007264 TAS     response to estradiol GO:0032355 IEA     response to cadmium ion GO:0046686 IEA     innate immune response GO:0045087 TAS     negative regulation of cellular component movement GO:0051271 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA     positive regulation of cell death GO:0010942 IDA     negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IEA     response to hypoxia GO:0001666 IEA     cellular response to lithium ion GO:0071285 IDA     mitotic cell cycle GO:0000278 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     negative regulation of transcription, DNA-templated GO:0045892 IDA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     G1/S transition of mitotic cell cycle GO:0000082 TAS     sensory perception of sound GO:0007605 IEA     cellular response to antibiotic GO:0071236 IEA     positive regulation of protein catabolic process GO:0045732 IDA     regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 TAS     negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 IEA     response to drug GO:0042493 IEA     negative regulation of cell growth GO:0030308 IDA     cell cycle arrest GO:0007050 IMP     response to glucose GO:0009749 IEA     mitotic cell cycle arrest GO:0071850 IDA     negative regulation of mitotic cell cycle GO:0045930 IDA     potassium ion transport GO:0006813 IEA     positive regulation of cell proliferation GO:0008284 IEA Subcellular Localization     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     Cul4A-RING E3 ubiquitin ligase complex GO:0031464 IDA     endosome GO:0005768 IEA     cytosol GO:0005829 TAS     nucleus GO:0005634 IDA