Gene description for UBE2B
Gene name	ubiquitin-conjugating enzyme E2B
Gene symbol	UBE2B
Other names/aliases	E2-17kDa HHR6B HR6B RAD6B UBC2
Species	Homo sapiens
Database cross references - UBE2B
ExoCarta	ExoCarta_7320
Entrez Gene	7320
HGNC	12473
MIM	179095
UniProt	P63146
UBE2B identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for UBE2B

Molecular Function     ubiquitin protein ligase activity GO:0061630 IBA     ligase activity GO:0016874 IEA     ubiquitin protein ligase binding GO:0031625 IPI     ubiquitin-protein transferase activity GO:0004842 IMP     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA Biological Process     maintenance of chromatin silencing GO:0006344 IEA     cellular response to insulin stimulus GO:0032869 IEA     sperm axoneme assembly GO:0007288 IEA     negative regulation of apoptotic process GO:0043066 IEA     response to UV GO:0009411 IGI     protein stabilization GO:0050821 IMP     ubiquitin-dependent protein catabolic process GO:0006511 NAS     protein ubiquitination GO:0016567 IDA     protein K63-linked ubiquitination GO:0070534 IDA     response to drug GO:0042493 IDA     spermatogenesis GO:0007283 TAS     translesion synthesis GO:0019985 TAS     positive regulation of reciprocal meiotic recombination GO:0010845 IEA     response to hypoxia GO:0001666 IEA     chiasma assembly GO:0051026 IEA     protein polyubiquitination GO:0000209 IMP     synaptonemal complex organization GO:0070193 IEA     DNA repair GO:0006281 TAS     protein K48-linked ubiquitination GO:0070936 IDA     negative regulation of cAMP-mediated signaling GO:0043951 IDA     in utero embryonic development GO:0001701 IEA     protein monoubiquitination GO:0006513 IMP     protein K11-linked ubiquitination GO:0070979 IDA     negative regulation of histone phosphorylation GO:0033128 IEA     cellular response to DNA damage stimulus GO:0006974 IDA     postreplication repair GO:0006301 NAS     histone lysine demethylation GO:0070076 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     canonical Wnt signaling pathway GO:0060070 ISS     protein autoubiquitination GO:0051865 IDA     histone H2A ubiquitination GO:0033522 IMP     DNA damage response, detection of DNA damage GO:0042769 TAS Subcellular Localization     HULC complex GO:0033503 IDA     nucleoplasm GO:0005654 TAS     nuclear chromatin GO:0000790 IBA     plasma membrane GO:0005886 IEA     replication fork GO:0005657 IDA     cytoplasm GO:0005737 IDA     XY body GO:0001741 IEA     chromatin GO:0000785 ISS     nucleus GO:0005634 IDA