Gene description for SEC23A
Gene name Sec23 homolog A (S. cerevisiae)
Gene symbol SEC23A
Other names/aliases CLSD
Species Homo sapiens
 Database cross references - SEC23A
ExoCarta ExoCarta_10484
Entrez Gene 10484
HGNC 10701
MIM 610511
UniProt Q15436  
 SEC23A identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for SEC23A
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    membrane organization GO:0061024 TAS
    COPII vesicle coating GO:0048208 TAS
    vesicle-mediated transport GO:0016192 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    post-translational protein modification GO:0043687 TAS
    intracellular protein transport GO:0006886 IEA
    cellular protein metabolic process GO:0044267 TAS
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
    small molecule metabolic process GO:0044281 TAS
    ER to Golgi vesicle-mediated transport GO:0006888 TAS
    protein N-linked glycosylation via asparagine GO:0018279 TAS
Subcellular Localization
    COPII vesicle coat GO:0030127 IEA
    ER to Golgi transport vesicle membrane GO:0012507 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    Golgi membrane GO:0000139 IEA
    cytosol GO:0005829 TAS
    endoplasmic reticulum GO:0005783 TAS
    smooth endoplasmic reticulum membrane GO:0030868 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified SEC23A in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SEC23A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC24C 9632
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 SEC24B 10427
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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