Gene description for OTUD1
Gene name OTU deubiquitinase 1
Gene symbol OTUD1
Other names/aliases DUBA7
OTDC1
Species Homo sapiens
 Database cross references - OTUD1
ExoCarta ExoCarta_220213
Entrez Gene 220213
HGNC 27346
MIM 612022
UniProt Q5VV17  
 OTUD1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for OTUD1
Molecular Function
    ubiquitin-specific protease activity GO:0004843 IDA
Biological Process
    protein K63-linked deubiquitination GO:0070536 IDA
 Experiment description of studies that identified OTUD1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for OTUD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OTUD1 is involved
No pathways found





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