Gene description for H3F3C
Gene name H3 histone, family 3C
Gene symbol H3F3C
Other names/aliases H3.5
Species Homo sapiens
 Database cross references - H3F3C
ExoCarta ExoCarta_440093
Vesiclepedia VP_440093
Entrez Gene 440093
HGNC 33164
MIM 616134
UniProt Q6NXT2  
 H3F3C identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
 Gene ontology annotations for H3F3C
Molecular Function
    protein heterodimerization activity GO:0046982 IEA
    protein binding GO:0005515 IPI
    nucleosomal DNA binding GO:0031492 IDA
Biological Process
    positive regulation of cell growth GO:0030307 IMP
Subcellular Localization
    nuclear euchromatin GO:0005719 IDA
    nucleosome GO:0000786 IEA
 Experiment description of studies that identified H3F3C in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101|CD63|CD81
EV Enriched markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 138
MISEV standards
EM
EV Biophysical techniques
HSP70|HSP90|RAB5|LAMP2|CD9
EV Enriched markers
HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
3
Experiment ID 143
MISEV standards
EM
EV Biophysical techniques
HSP70|HSP90|RAB5|LAMP2|CD9
EV Enriched markers
HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for H3F3C
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which H3F3C is involved
No pathways found





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