Gene description for Fbl
Gene name fibrillarin
Gene symbol Fbl
Other names/aliases AL022665
FIB
FLRN
RNU3IP1
Species Mus musculus
 Database cross references - Fbl
ExoCarta ExoCarta_14113
Entrez Gene 14113
UniProt P35550  
 Fbl identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Fbl
Molecular Function
    rRNA (cytosine-2'-O-)-methyltransferase activity GO:0070677 IEA
    trimethylamine methyltransferase activity GO:0043834 IEA
    trihydroxyferuloyl spermidine O-methyltransferase activity GO:0080012 IEA
    protein-lysine N-methyltransferase activity GO:0016279 IEA
    tRNA (guanine) methyltransferase activity GO:0016423 IEA
    tRNA (adenine-57, 58-N(1)-) methyltransferase activity GO:0043827 IEA
    protein methyltransferase activity GO:0008276 IEA
    N-methyltransferase activity GO:0008170 IEA
    rRNA methyltransferase activity GO:0008649 IBA
    RNA methyltransferase activity GO:0008173 IEA
    4,5-dihydroxybenzo(a)pyrene methyltransferase activity GO:0034807 IEA
    lysine N-methyltransferase activity GO:0016278 IEA
    hydroxyneurosporene-O-methyltransferase activity GO:0043803 IEA
    demethylmenaquinone methyltransferase activity GO:0043770 IEA
    rRNA (uridine) methyltransferase activity GO:0016436 IEA
    mRNA methyltransferase activity GO:0008174 IEA
    O-methyltransferase activity GO:0008171 IEA
    rRNA (cytosine) methyltransferase activity GO:0016434 IEA
    cobalt-precorrin-5B C1-methyltransferase activity GO:0043780 IEA
    poly(A) RNA binding GO:0044822 ISO
    tRNA (adenine-N1-)-methyltransferase activity GO:0016429 IEA
    cobalt-precorrin-6B C5-methyltransferase activity GO:0043776 IEA
    methylarsonite methyltransferase activity GO:0030792 IEA
    tRNA (adenine) methyltransferase activity GO:0016426 IEA
    tRNA (cytosine) methyltransferase activity GO:0016427 IEA
    DNA-methyltransferase activity GO:0009008 IEA
    cobalt-precorrin-3 C17-methyltransferase activity GO:0043782 IEA
    dimethylamine methyltransferase activity GO:0043791 IEA
    arginine N-methyltransferase activity GO:0016273 IEA
    tRNA (guanine-N1-)-methyltransferase activity GO:0009019 IEA
    tRNA (cytosine-5-)-methyltransferase activity GO:0016428 IEA
    tRNA (cytosine-2'-O-)-methyltransferase activity GO:0052666 IEA
    dimethylarsinite methyltransferase activity GO:0034541 IEA
    protein-arginine N-methyltransferase activity GO:0016274 IEA
    transferase activity GO:0016740 IEA
    rRNA (cytosine-C5-)-methyltransferase activity GO:0009383 IEA
    1-phenanthrol methyltransferase activity GO:0018707 IEA
    S-methyltransferase activity GO:0008172 IEA
    tRNA (cytosine-3-)-methyltransferase activity GO:0052735 IEA
    P-methyltransferase activity GO:0051994 IEA
    Se-methyltransferase activity GO:0051995 IEA
    C-methyltransferase activity GO:0008169 IEA
    protein-arginine N5-methyltransferase activity GO:0019702 IEA
    2-phytyl-1,4-naphthoquinone methyltransferase activity GO:0052624 IEA
    rRNA (cytosine-N4-)-methyltransferase activity GO:0071424 IEA
    1-hydroxy-6-methoxypyrene methyltransferase activity GO:0034933 IEA
    methyltransferase activity GO:0008168 IEA
    cobalt-precorrin-7 C15-methyltransferase activity GO:0043777 IEA
    methylamine-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043833 IEA
    tRNA (guanine-N2-)-methyltransferase activity GO:0004809 IEA
    rRNA (adenine-N6-)-methyltransferase activity GO:0008988 IEA
    protein C-terminal leucine carboxyl O-methyltransferase activity GO:0018423 IEA
    rRNA (adenine) methyltransferase activity GO:0016433 IEA
    rRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179 IEA
    rRNA (guanine) methyltransferase activity GO:0016435 IEA
    tRNA methyltransferase activity GO:0008175 IEA
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IEA
    monomethylamine methyltransferase activity GO:0043852 IEA
    2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GO:0008425 IEA
    histone-glutamine methyltransferase activity GO:1990259 ISO
    1-hydroxypyrene methyltransferase activity GO:0034931 IEA
    tRNA (uracil-2'-O-)-methyltransferase activity GO:0052665 IEA
    tRNA (uracil) methyltransferase activity GO:0016300 IEA
    phosphomethylethanolamine N-methyltransferase activity GO:0052667 IEA
    RNA binding GO:0003723 ISO
    protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IEA
    methanol-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043851 IEA
    selenocysteine methyltransferase activity GO:0016205 IEA
Biological Process
    tRNA processing GO:0008033 IEA
    methylation GO:0032259 IEA
    box C/D snoRNA 3'-end processing GO:0000494 IBA
    histone glutamine methylation GO:1990258 ISO
    RNA processing GO:0006396 ISO
    snoRNA metabolic process GO:0016074 IMP
    osteoblast differentiation GO:0001649 ISO
    rRNA methylation GO:0031167 IBA
    rRNA processing GO:0006364 IEA
Subcellular Localization
    membrane GO:0016020 ISO
    nucleus GO:0005634 ISO
    ribonucleoprotein complex GO:0030529 IEA
    box C/D snoRNP complex GO:0031428 IBA
    Cajal body GO:0015030 ISO
    dense fibrillar component GO:0001651 ISO
    small-subunit processome GO:0032040 IBA
    extracellular exosome GO:0070062 ISO
    nucleolus GO:0005730 ISS
    granular component GO:0001652 IDA
 Experiment description of studies that identified Fbl in exosomes
1
Experiment ID 263
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fbl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fbl is involved
No pathways found





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