Gene description for SLCO4A1
Gene name solute carrier organic anion transporter family, member 4A1
Gene symbol SLCO4A1
Other names/aliases OATP-E
OATP1
OATP4A1
OATPE
OATPRP1
POAT
SLC21A12
Species Homo sapiens
 Database cross references - SLCO4A1
ExoCarta ExoCarta_28231
Vesiclepedia VP_28231
Entrez Gene 28231
HGNC 10953
MIM 612436
UniProt Q96BD0  
 SLCO4A1 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLCO4A1
Molecular Function
    protein binding GO:0005515 IPI
    organic anion transmembrane transporter activity GO:0008514 IDA
    prostaglandin transmembrane transporter activity GO:0015132 IDA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 IBA
    thyroid hormone transmembrane transporter activity GO:0015349 IBA
Biological Process
    monoatomic ion transport GO:0006811 IEA
    prostaglandin transport GO:0015732 IEA
    sodium-independent organic anion transport GO:0043252 IBA
    transmembrane transport GO:0055085 IEA
    thyroid hormone transport GO:0070327 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IBA
 Experiment description of studies that identified SLCO4A1 in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLCO4A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLRC1  
Affinity Capture-MS Homo sapiens
2 LGALS12  
Affinity Capture-MS Homo sapiens
3 RAB35 11021
Proximity Label-MS Homo sapiens
4 FASN 2194
Negative Genetic Homo sapiens
5 MARCKS 4082
Proximity Label-MS Homo sapiens
6 GP9 2815
Affinity Capture-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 SLC2A4  
Affinity Capture-MS Homo sapiens
9 KLK5 25818
Affinity Capture-MS Homo sapiens
10 MFSD4  
Affinity Capture-MS Homo sapiens
11 Fbl 14113
Affinity Capture-MS Mus musculus
12 TAZ  
Affinity Capture-MS Homo sapiens
13 CCR4 1233
Two-hybrid Homo sapiens
14 LAMP1 3916
Proximity Label-MS Homo sapiens
15 CLEC2D  
Affinity Capture-MS Homo sapiens
16 LGALS3 3958
Affinity Capture-MS Homo sapiens
17 GPR25  
Two-hybrid Homo sapiens
18 ARMC6 93436
Affinity Capture-MS Homo sapiens
19 RAB4A 5867
Proximity Label-MS Homo sapiens
20 ACACA 31
Negative Genetic Homo sapiens
21 BSND  
Affinity Capture-MS Homo sapiens
22 RAB2A 5862
Proximity Label-MS Homo sapiens
23 KRAS 3845
Proximity Label-MS Homo sapiens
24 RAB5C 5878
Proximity Label-MS Homo sapiens
25 RHOB 388
Proximity Label-MS Homo sapiens
26 XRCC3  
Affinity Capture-MS Homo sapiens
27 HAX1  
Affinity Capture-MS Homo sapiens
28 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
29 Gsk3b  
Affinity Capture-MS Mus musculus
30 KIAA1644  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here