Gene description for HELLS
Gene name helicase, lymphoid-specific
Gene symbol HELLS
Other names/aliases LSH
Nbla10143
PASG
SMARCA6
Species Homo sapiens
 Database cross references - HELLS
ExoCarta ExoCarta_3070
Entrez Gene 3070
HGNC 4861
MIM 603946
UniProt Q9NRZ9  
 HELLS identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for HELLS
Molecular Function
    protein binding GO:0005515 IPI
    helicase activity GO:0004386 IEA
    ATP binding GO:0005524 IEA
    DNA binding GO:0003677 IEA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    cell division GO:0051301 IEA
    multicellular organismal development GO:0007275 ISS
    mitotic nuclear division GO:0007067 IEA
    pericentric heterochromatin assembly GO:0031508 ISS
    methylation-dependent chromatin silencing GO:0006346 ISS
    lymphocyte proliferation GO:0046651 ISS
    maintenance of DNA methylation GO:0010216 ISS
Subcellular Localization
    nucleus GO:0005634 IEA
    pericentric heterochromatin GO:0005721 ISS
    chromosome, centromeric region GO:0000775 ISS
 Experiment description of studies that identified HELLS in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HELLS
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HELLS is involved
No pathways found





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