Gene description for F9
Gene name coagulation factor IX
Gene symbol F9
Other names/aliases FIX
Species Homo sapiens
 Database cross references - F9
ExoCarta ExoCarta_2158
Entrez Gene 2158
HGNC 3551
MIM 300746
UniProt P00740  
 F9 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for F9
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
    endopeptidase activity GO:0004175 IDA
    calcium ion binding GO:0005509 IDA
Biological Process
    proteolysis GO:0006508 TAS
    blood coagulation, intrinsic pathway GO:0007597 TAS
    post-translational protein modification GO:0043687 TAS
    cellular protein metabolic process GO:0044267 TAS
    zymogen activation GO:0031638 IDA
    peptidyl-glutamic acid carboxylation GO:0017187 TAS
    blood coagulation, extrinsic pathway GO:0007598 TAS
    blood coagulation GO:0007596 TAS
Subcellular Localization
    extracellular space GO:0005615 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    Golgi lumen GO:0005796 TAS
    plasma membrane GO:0005886 TAS
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified F9 in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for F9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F7 2155
Invitro Homo sapiens
2 LRP1 4035
Invitro Homo sapiens
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