Gene description for NUMA1
Gene name nuclear mitotic apparatus protein 1
Gene symbol NUMA1
Other names/aliases NMP-22
NUMA
Species Homo sapiens
 Database cross references - NUMA1
ExoCarta ExoCarta_4926
Vesiclepedia VP_4926
Entrez Gene 4926
HGNC 8059
MIM 164009
UniProt Q14980  
 NUMA1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
Thymus 23844026    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for NUMA1
Molecular Function
    structural molecule activity GO:0005198 TAS
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 IDA
    tubulin binding GO:0015631 IDA
    protein domain specific binding GO:0019904 IPI
    phosphatidylinositol binding GO:0035091 IDA
    protein-containing complex binding GO:0044877 IDA
    microtubule plus-end binding GO:0051010 IDA
    microtubule minus-end binding GO:0051011 IDA
    dynein complex binding GO:0070840 IDA
    disordered domain specific binding GO:0097718 IMP
Biological Process
    establishment of mitotic spindle orientation GO:0000132 IBA
    establishment of mitotic spindle orientation GO:0000132 IDA
    establishment of mitotic spindle orientation GO:0000132 IMP
    establishment of mitotic spindle orientation GO:0000132 ISS
    microtubule bundle formation GO:0001578 IMP
    nucleus organization GO:0006997 TAS
    positive regulation of BMP signaling pathway GO:0030513 ISS
    astral microtubule organization GO:0030953 IDA
    astral microtubule organization GO:0030953 IMP
    positive regulation of microtubule polymerization GO:0031116 IMP
    positive regulation of intracellular transport GO:0032388 IMP
    positive regulation of keratinocyte differentiation GO:0045618 ISS
    cell division GO:0051301 IEA
    meiotic cell cycle GO:0051321 IEA
    positive regulation of hair follicle development GO:0051798 ISS
    positive regulation of chromosome segregation GO:0051984 IMP
    anastral spindle assembly GO:0055048 IMP
    regulation of mitotic spindle organization GO:0060236 IDA
    regulation of mitotic spindle organization GO:0060236 IMP
    regulation of metaphase plate congression GO:0090235 IMP
    positive regulation of protein localization to spindle pole body GO:1902365 IDA
    positive regulation of mitotic spindle elongation GO:1902846 IMP
    positive regulation of protein localization to cell cortex GO:1904778 IMP
    positive regulation of chromosome separation GO:1905820 IMP
    positive regulation of spindle assembly GO:1905832 IMP
Subcellular Localization
    spindle pole GO:0000922 IBA
    spindle pole GO:0000922 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IEA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    spindle GO:0005819 TAS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    spindle microtubule GO:0005876 IBA
    spindle microtubule GO:0005876 IDA
    plasma membrane GO:0005886 IDA
    cell cortex GO:0005938 IDA
    lateral plasma membrane GO:0016328 IEA
    nuclear matrix GO:0016363 IDA
    dendrite GO:0030425 IEA
    spindle pole centrosome GO:0031616 IDA
    protein-containing complex GO:0032991 IDA
    protein-containing complex GO:0032991 IMP
    microtubule plus-end GO:0035371 IDA
    microtubule minus-end GO:0036449 IDA
    neuronal cell body GO:0043025 IEA
    cortical microtubule GO:0055028 IDA
    mitotic spindle astral microtubule GO:0061673 IDA
    extracellular exosome GO:0070062 HDA
    mitotic spindle GO:0072686 IDA
    microtubule bundle GO:0097427 IDA
    mitotic spindle pole GO:0097431 IDA
    mitotic spindle pole GO:0097431 IMP
    lateral cell cortex GO:0097575 ISS
    cell cortex region GO:0099738 IDA
    cytoplasmic microtubule bundle GO:1905720 IDA
    mitotic spindle midzone GO:1990023 IDA
 Experiment description of studies that identified NUMA1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
24
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
29
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
34
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
35
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
36
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NUMA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPSM2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 KRT4 3851
Affinity Capture-MS Homo sapiens
4 PSMA4 5685
Co-fractionation Homo sapiens
5 CRK 1398
Affinity Capture-MS Homo sapiens
6 EIF2B2 8892
Affinity Capture-MS Homo sapiens
7 ACTC1 70
Proximity Label-MS Homo sapiens
8 BRCA1 672
Affinity Capture-MS Homo sapiens
9 SMARCE1 6605
Affinity Capture-MS Homo sapiens
10 KIF20A 10112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 BRD2  
Affinity Capture-MS Homo sapiens
12 MAP4K4 9448
Affinity Capture-MS Homo sapiens
13 KPNA2 3838
Affinity Capture-MS Homo sapiens
14 APEX1 328
Proximity Label-MS Homo sapiens
15 WDR76  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MEAF6  
Affinity Capture-MS Homo sapiens
17 MTF2  
Affinity Capture-MS Homo sapiens
18 CTDSPL2  
Affinity Capture-MS Homo sapiens
19 NUP153 9972
Affinity Capture-MS Homo sapiens
20 NAGA 4668
Affinity Capture-MS Homo sapiens
21 POLR3G  
Affinity Capture-MS Homo sapiens
22 BRCC3 79184
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
23 KRT78 196374
Affinity Capture-MS Homo sapiens
24 EIF3E 3646
Co-fractionation Homo sapiens
25 DYNLL1 8655
Affinity Capture-Western Homo sapiens
26 KIF14 9928
Affinity Capture-MS Homo sapiens
27 EMC9  
Affinity Capture-MS Homo sapiens
28 AURKA 6790
Affinity Capture-MS Homo sapiens
29 BRPF1  
Affinity Capture-MS Homo sapiens
30 GPSM1 26086
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 UBE4B 10277
Co-fractionation Homo sapiens
32 MRE11A 4361
Affinity Capture-MS Homo sapiens
33 TOP2B 7155
Affinity Capture-MS Homo sapiens
34 ATAD2 29028
Affinity Capture-MS Homo sapiens
35 MAPRE1 22919
Affinity Capture-MS Homo sapiens
36 UBE2I 7329
Affinity Capture-MS Homo sapiens
37 ZMYM3  
Affinity Capture-MS Homo sapiens
38 Srp72  
Affinity Capture-MS Mus musculus
39 OGT 8473
Affinity Capture-MS Homo sapiens
40 CBX5 23468
Affinity Capture-MS Homo sapiens
41 BANF1 8815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 YWHAQ 10971
Reconstituted Complex Homo sapiens
43 ENO1 2023
Affinity Capture-RNA Homo sapiens
44 SCOC 60592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 BRAP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 AHCTF1 25909
Affinity Capture-MS Homo sapiens
47 USP28 57646
Affinity Capture-Western Homo sapiens
48 CD3EAP  
Co-fractionation Homo sapiens
49 SCARNA22  
Affinity Capture-RNA Homo sapiens
50 ANLN 54443
Affinity Capture-MS Homo sapiens
51 BRD7  
Affinity Capture-MS Homo sapiens
52 HIST1H2AD 3013
Affinity Capture-MS Homo sapiens
53 EPB41L1 2036
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
54 C9orf78 51759
Affinity Capture-MS Homo sapiens
55 SIRT7  
Affinity Capture-MS Homo sapiens
56 PAPD5 64282
Affinity Capture-MS Homo sapiens
57 RBBP4 5928
Affinity Capture-MS Homo sapiens
58 NTHL1  
Affinity Capture-MS Homo sapiens
59 ZNF512  
Affinity Capture-MS Homo sapiens
60 ARHGAP44  
Affinity Capture-MS Homo sapiens
61 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
62 DLST 1743
Co-fractionation Homo sapiens
63 RPL35A 6165
Co-fractionation Homo sapiens
64 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
65 CSDE1 7812
Co-fractionation Homo sapiens
66 HIST1H2AJ 8331
Affinity Capture-MS Homo sapiens
67 PYHIN1  
Affinity Capture-MS Homo sapiens
68 DNAH6 1768
Cross-Linking-MS (XL-MS) Homo sapiens
69 RPS27A 6233
Affinity Capture-MS Homo sapiens
70 DVL1 1855
Affinity Capture-Western Homo sapiens
71 FAM175B 23172
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
72 HIST1H2AC 8334
Affinity Capture-MS Homo sapiens
73 EIF3I 8668
Co-fractionation Homo sapiens
74 RUVBL2 10856
Affinity Capture-MS Homo sapiens
75 ATG13 9776
Affinity Capture-MS Homo sapiens
76 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
77 MTA1 9112
Affinity Capture-MS Homo sapiens
78 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
79 PARP2  
Affinity Capture-MS Homo sapiens
80 DYNC1H1 1778
Affinity Capture-Western Homo sapiens
81 CDC16 8881
Affinity Capture-MS Homo sapiens
82 KXD1 79036
Affinity Capture-MS Homo sapiens
83 INTS3 65123
Affinity Capture-MS Homo sapiens
84 CUL7 9820
Affinity Capture-MS Homo sapiens
85 RPA1 6117
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
86 R3HCC1 203069
Affinity Capture-MS Homo sapiens
87 PWWP2A  
Affinity Capture-MS Homo sapiens
88 CHD4 1108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 RANGAP1 5905
Affinity Capture-MS Homo sapiens
90 MCM3 4172
Affinity Capture-MS Homo sapiens
91 NCOA6  
Affinity Capture-MS Homo sapiens
92 MCM2 4171
Affinity Capture-MS Homo sapiens
93 BRDT  
Affinity Capture-MS Homo sapiens
94 RPA2 6118
Affinity Capture-MS Homo sapiens
95 NUP62 23636
Affinity Capture-MS Homo sapiens
96 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
97 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
98 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
99 TERF2IP 54386
Two-hybrid Homo sapiens
100 SETDB1  
Affinity Capture-MS Homo sapiens
101 NUP160 23279
Affinity Capture-MS Homo sapiens
102 KIAA1598 57698
Co-fractionation Homo sapiens
103 PSIP1 11168
Affinity Capture-MS Homo sapiens
104 XRCC1 7515
Affinity Capture-MS Homo sapiens
105 SRCAP  
Affinity Capture-MS Homo sapiens
106 KIF22  
Affinity Capture-MS Homo sapiens
107 MYO5B 4645
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
108 H1FX 8971
Affinity Capture-MS Homo sapiens
109 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
110 WDR83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 HIST2H3A 333932
Affinity Capture-MS Homo sapiens
112 PRC1 9055
Affinity Capture-MS Homo sapiens
113 NPM1 4869
Affinity Capture-MS Homo sapiens
114 ACTR1A 10121
Affinity Capture-Western Homo sapiens
115 NUP93 9688
Affinity Capture-MS Homo sapiens
116 OBSL1 23363
Affinity Capture-MS Homo sapiens
117 FBXO28  
Affinity Capture-MS Homo sapiens
118 KRT72 140807
Affinity Capture-MS Homo sapiens
119 WIZ 58525
Affinity Capture-MS Homo sapiens
120 ASF1A 25842
Proximity Label-MS Homo sapiens
121 DNAH2 146754
Cross-Linking-MS (XL-MS) Homo sapiens
122 RIF1  
Affinity Capture-MS Homo sapiens
123 PHF10  
Affinity Capture-MS Homo sapiens
124 RLF 6018
Affinity Capture-MS Homo sapiens
125 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
126 HNRNPA0 10949
Cross-Linking-MS (XL-MS) Homo sapiens
127 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 RPL4 6124
Cross-Linking-MS (XL-MS) Homo sapiens
129 WHSC1 7468
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 HELLS 3070
Affinity Capture-MS Homo sapiens
131 NBN 4683
Affinity Capture-MS Homo sapiens
132 Tnks2  
Affinity Capture-MS Mus musculus
133 POLB 5423
Affinity Capture-MS Homo sapiens
134 YEATS4  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
135 CHRAC1  
Affinity Capture-MS Homo sapiens
136 ATAD2B 54454
Affinity Capture-MS Homo sapiens
137 SMARCAD1  
Affinity Capture-MS Homo sapiens
138 TP53BP1 7158
Affinity Capture-MS Homo sapiens
139 TNKS 8658
Reconstituted Complex Homo sapiens
140 MEX3A  
Affinity Capture-RNA Homo sapiens
141 NUP88 4927
Affinity Capture-MS Homo sapiens
142 PHIP 55023
Affinity Capture-MS Homo sapiens
143 HNRNPA1L2 144983
Cross-Linking-MS (XL-MS) Homo sapiens
144 CDK2 1017
Affinity Capture-MS Homo sapiens
145 MYC  
Affinity Capture-MS Homo sapiens
146 EHMT1  
Affinity Capture-MS Homo sapiens
147 SUV39H2 79723
Affinity Capture-MS Homo sapiens
148 RAI1 10743
Affinity Capture-MS Homo sapiens
149 DDB1 1642
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
150 BMI1  
Affinity Capture-MS Homo sapiens
151 RAE1 8480
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
152 EIF3H 8667
Co-fractionation Homo sapiens
153 NUP54 53371
Affinity Capture-MS Homo sapiens
154 TERF2  
Two-hybrid Homo sapiens
155 PARP1 142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 NUP85 79902
Affinity Capture-MS Homo sapiens
157 KEAP1 9817
Negative Genetic Homo sapiens
158 CAPZA2 830
Co-fractionation Homo sapiens
159 CAPRIN1 4076
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
160 CDK6 1021
Biochemical Activity Homo sapiens
161 EPB41L2 2037
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
162 MAP2K1 5604
Affinity Capture-MS Homo sapiens
163 RAD50 10111
Affinity Capture-MS Homo sapiens
164 TRIP12 9320
Affinity Capture-MS Homo sapiens
165 LCOR 84458
Affinity Capture-MS Homo sapiens
166 Ranbp2  
Affinity Capture-MS Mus musculus
167 BRD1 23774
Affinity Capture-MS Homo sapiens
168 GLYR1 84656
Affinity Capture-MS Homo sapiens
169 KAT6A  
Affinity Capture-MS Homo sapiens
170 RCOR1  
Affinity Capture-MS Homo sapiens
171 CUL4A 8451
Affinity Capture-MS Homo sapiens
172 NUPL2 11097
Affinity Capture-MS Homo sapiens
173 MCM7 4176
Affinity Capture-MS Homo sapiens
174 TCF7L2  
Affinity Capture-MS Homo sapiens
175 SMC3 9126
Affinity Capture-Western Homo sapiens
176 RFC5 5985
Affinity Capture-MS Homo sapiens
177 HIST2H2AA3 8337
Affinity Capture-MS Homo sapiens
178 KAT7  
Affinity Capture-MS Homo sapiens
179 CAPZB 832
Co-fractionation Homo sapiens
180 RUVBL1 8607
Co-fractionation Homo sapiens
181 TRIM28 10155
Affinity Capture-MS Homo sapiens
182 EMILIN1 11117
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
183 VARS 7407
Cross-Linking-MS (XL-MS) Homo sapiens
184 SMARCA1 6594
Affinity Capture-MS Homo sapiens
185 SUV39H1  
Affinity Capture-MS Homo sapiens
186 MDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 LINC00240  
Affinity Capture-MS Homo sapiens
188 MCM6 4175
Affinity Capture-MS Homo sapiens
189 RCC1 1104
Affinity Capture-MS Homo sapiens
190 EML3 256364
Affinity Capture-MS Homo sapiens
191 NCK1 4690
Affinity Capture-MS Homo sapiens
192 NCSTN 23385
Co-fractionation Homo sapiens
193 NUP155 9631
Affinity Capture-MS Homo sapiens
194 EPB41L3 23136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
195 FOXC1  
Affinity Capture-MS Homo sapiens
196 RTF1 23168
Co-fractionation Homo sapiens
197 PHF14 9678
Affinity Capture-MS Homo sapiens
198 CLNS1A 1207
Affinity Capture-MS Homo sapiens
199 ARHGEF1 9138
Affinity Capture-MS Homo sapiens
200 CBX3 11335
Affinity Capture-MS Homo sapiens
201 CHMP4B 128866
Affinity Capture-MS Homo sapiens
202 BTF3 689
Affinity Capture-MS Homo sapiens
203 BARD1 580
Affinity Capture-MS Homo sapiens
204 NTRK1 4914
Affinity Capture-MS Homo sapiens
205 U2AF2 11338
Affinity Capture-MS Homo sapiens
206 RPA4  
Proximity Label-MS Homo sapiens
207 Tnks  
Affinity Capture-MS Mus musculus
208 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
209 NECAP1 25977
Affinity Capture-MS Homo sapiens
210 HNRNPA3 220988
Cross-Linking-MS (XL-MS) Homo sapiens
211 HDAC5 10014
Affinity Capture-MS Homo sapiens
212 NUP210 23225
Affinity Capture-MS Homo sapiens
213 CAMK1 8536
Affinity Capture-MS Homo sapiens
214 RAN 5901
Affinity Capture-MS Homo sapiens
215 POLR2B 5431
Affinity Capture-MS Homo sapiens
216 SLX4  
Affinity Capture-MS Homo sapiens
217 ZBTB2 57621
Affinity Capture-MS Homo sapiens
218 KMT2A  
Affinity Capture-MS Homo sapiens
219 CDC73  
Co-fractionation Homo sapiens
220 BAZ1B 9031
Affinity Capture-MS Homo sapiens
221 SMARCA5 8467
Affinity Capture-MS Homo sapiens
222 CDC27 996
Affinity Capture-MS Homo sapiens
223 CCDC57 284001
Two-hybrid Homo sapiens
224 ASPM 259266
Affinity Capture-MS Homo sapiens
225 DCAF13 25879
Cross-Linking-MS (XL-MS) Homo sapiens
226 YY1 7528
Proximity Label-MS Homo sapiens
227 H1F0 3005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
228 HNRNPA1 3178
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
229 NUP214 8021
Affinity Capture-MS Homo sapiens
230 RPS13 6207
Co-fractionation Homo sapiens
231 ZC3H18  
Co-fractionation Homo sapiens
232 DCAF8L2  
Affinity Capture-MS Homo sapiens
233 EPB41 2035
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
234 HP1BP3 50809
Affinity Capture-MS Homo sapiens
235 MATR3 9782
Affinity Capture-MS Homo sapiens
236 RNF2  
Affinity Capture-MS Homo sapiens
237 GMCL1  
Two-hybrid Homo sapiens
238 RBBP5 5929
Affinity Capture-MS Homo sapiens
239 NAA10 8260
Co-fractionation Homo sapiens
240 PIGR 5284
Affinity Capture-MS Homo sapiens
241 SUMO1 7341
Affinity Capture-MS Homo sapiens
242 HECTD1 25831
Affinity Capture-MS Homo sapiens
243 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
244 PRMT3 10196
Co-fractionation Homo sapiens
245 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
246 NUP205 23165
Affinity Capture-MS Homo sapiens
247 LIG3 3980
Affinity Capture-MS Homo sapiens
248 RPL6 6128
Cross-Linking-MS (XL-MS) Homo sapiens
249 CHAMP1  
Affinity Capture-MS Homo sapiens
250 MEN1 4221
Affinity Capture-MS Homo sapiens
251 PDHA1 5160
Affinity Capture-MS Homo sapiens
252 PBRM1 55193
Affinity Capture-MS Homo sapiens
253 PTTG1  
Synthetic Growth Defect Homo sapiens
254 MKI67  
Affinity Capture-MS Homo sapiens
255 ZNF280C  
Affinity Capture-MS Homo sapiens
256 PDZD8 118987
Affinity Capture-MS Homo sapiens
257 MED12  
Affinity Capture-MS Homo sapiens
258 MYO1E 4643
Affinity Capture-MS Homo sapiens
259 ERG  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
260 RSF1  
Affinity Capture-MS Homo sapiens
261 UBA6 55236
Co-fractionation Homo sapiens
262 NUCKS1 64710
Affinity Capture-MS Homo sapiens
263 POGZ 23126
Affinity Capture-MS Homo sapiens
264 EP300 2033
Affinity Capture-MS Homo sapiens
265 EIF3L 51386
Co-fractionation Homo sapiens
266 UBE2H 7328
Affinity Capture-MS Homo sapiens
267 LGR4 55366
Affinity Capture-MS Homo sapiens
268 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
269 KPNB1 3837
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
270 NUPL1 9818
Affinity Capture-MS Homo sapiens
271 DVL3 1857
Affinity Capture-Western Homo sapiens
272 RNF40 9810
Co-fractionation Homo sapiens
273 KIAA1429 25962
Affinity Capture-MS Homo sapiens
274 TOP2A 7153
Affinity Capture-MS Homo sapiens
275 FBXW7  
Affinity Capture-MS Homo sapiens
276 IMPDH2 3615
Co-fractionation Homo sapiens
277 H2AFY2 55506
Affinity Capture-MS Homo sapiens
278 HMGA1 3159
Affinity Capture-MS Homo sapiens
279 ABCE1 6059
Affinity Capture-MS Homo sapiens
280 EED  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
281 ANAPC7 51434
Affinity Capture-MS Homo sapiens
282 MYCN  
Affinity Capture-MS Homo sapiens
283 SMARCB1 6598
Affinity Capture-MS Homo sapiens
284 DVL2 1856
Affinity Capture-Western Homo sapiens
285 ESR1  
Affinity Capture-MS Homo sapiens
286 H2AFZ 3015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
287 NEDD8-MDP1 100528064
Affinity Capture-MS Homo sapiens
288 TCP10L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
289 ECT2 1894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
290 RGPD3  
Affinity Capture-MS Homo sapiens
291 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
292 ZNF22  
Affinity Capture-MS Homo sapiens
293 PRDM2  
Affinity Capture-MS Homo sapiens
294 SMARCA4 6597
Affinity Capture-MS Homo sapiens
295 VCP 7415
Affinity Capture-MS Homo sapiens
296 DDX5 1655
Co-fractionation Homo sapiens
297 ACTL6A 86
Affinity Capture-MS Homo sapiens
298 KRT75 9119
Affinity Capture-MS Homo sapiens
299 SUMO2 6613
Reconstituted Complex Homo sapiens
300 ARRDC3 57561
Affinity Capture-MS Homo sapiens
301 SMC1A 8243
Affinity Capture-Western Homo sapiens
302 PML 5371
Affinity Capture-MS Homo sapiens
303 BRD4 23476
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
304 H2AFY 9555
Affinity Capture-MS Homo sapiens
305 ZMYM4  
Affinity Capture-MS Homo sapiens
306 TCP10  
Affinity Capture-MS Homo sapiens
307 IPO5 3843
Co-fractionation Homo sapiens
308 HIST1H3A 8350
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
309 FANCD2  
Affinity Capture-MS Homo sapiens
310 CBX8 57332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
311 PNN 5411
Affinity Capture-MS Homo sapiens
312 CTNNB1 1499
Affinity Capture-MS Homo sapiens
313 ADNP 23394
Affinity Capture-MS Homo sapiens
314 MCM4 4173
Affinity Capture-MS Homo sapiens
315 CBX2  
Affinity Capture-MS Homo sapiens
316 SUZ12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
317 NXF1 10482
Affinity Capture-RNA Homo sapiens
318 CDYL 9425
Affinity Capture-MS Homo sapiens
319 H3F3B 3021
Affinity Capture-MS Homo sapiens
320 BAZ1A 11177
Affinity Capture-MS Homo sapiens
321 BRD3 8019
Affinity Capture-MS Homo sapiens
322 CCDC8  
Affinity Capture-MS Homo sapiens
323 H2AFX 3014
Affinity Capture-MS Homo sapiens
324 Cbx1  
Affinity Capture-MS Mus musculus
325 UBQLN4 56893
Affinity Capture-MS Homo sapiens
326 SIRT6  
Affinity Capture-MS Homo sapiens
327 MPP6 51678
Affinity Capture-MS Homo sapiens
328 SHANK3 85358
Affinity Capture-MS Homo sapiens
329 NUP133 55746
Affinity Capture-MS Homo sapiens
330 SRRM1 10250
Co-fractionation Homo sapiens
331 RPAP1  
Affinity Capture-MS Homo sapiens
332 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
333 HMGN5 79366
Affinity Capture-MS Homo sapiens
334 SMURF1 57154
Affinity Capture-MS Homo sapiens
335 PIM1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
336 HIST1H2BD 3017
Affinity Capture-MS Homo sapiens
337 NUP35 129401
Affinity Capture-MS Homo sapiens
338 NUP98 4928
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
339 NUP107 57122
Affinity Capture-MS Homo sapiens
340 TERF1 7013
Two-hybrid Homo sapiens
341 MOV10 4343
Affinity Capture-RNA Homo sapiens
342 EZH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
343 PINK1  
Affinity Capture-MS Homo sapiens
344 RANBP2 5903
Affinity Capture-MS Homo sapiens
345 XRCC6 2547
Proximity Label-MS Homo sapiens
346 SRM 6723
Co-fractionation Homo sapiens
347 CNDP2 55748
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here