Gene description for NUP205
Gene name nucleoporin 205kDa
Gene symbol NUP205
Other names/aliases C7orf14
Species Homo sapiens
 Database cross references - NUP205
ExoCarta ExoCarta_23165
Entrez Gene 23165
HGNC 18658
MIM 614352
UniProt Q92621  
 NUP205 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NUP205
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of nuclear pore GO:0017056 IMP
Biological Process
    viral life cycle GO:0019058 TAS
    protein sumoylation GO:0016925 TAS
    viral process GO:0016032 TAS
    glucose transport GO:0015758 TAS
    mRNA transport GO:0051028 IEA
    mitotic nuclear envelope disassembly GO:0007077 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    nuclear pore complex assembly GO:0051292 IMP
    nucleocytoplasmic transport GO:0006913 TAS
    transmembrane transport GO:0055085 TAS
    regulation of glucose transport GO:0010827 TAS
    cellular protein metabolic process GO:0044267 TAS
    small molecule metabolic process GO:0044281 TAS
    hexose transport GO:0008645 TAS
    regulation of cellular response to heat GO:1900034 TAS
    gene expression GO:0010467 TAS
    post-translational protein modification GO:0043687 TAS
    mitotic cell cycle GO:0000278 TAS
    cellular response to heat GO:0034605 TAS
    protein import into nucleus, docking GO:0000059 TAS
    carbohydrate metabolic process GO:0005975 TAS
    viral transcription GO:0019083 TAS
Subcellular Localization
    nuclear pore GO:0005643 NAS
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    membrane GO:0016020 IDA
    nuclear membrane GO:0031965 IDA
    nuclear envelope GO:0005635 TAS
    nuclear periphery GO:0034399 IDA
 Experiment description of studies that identified NUP205 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NUP205
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAGED1  
Affinity Capture-MS Homo sapiens
2 PHLDA3  
Affinity Capture-MS Homo sapiens
3 PHB2 11331
Affinity Capture-MS Homo sapiens
4 TTBK1  
Affinity Capture-MS Homo sapiens
5 MYC  
Affinity Capture-MS Homo sapiens
6 TPR 7175
Affinity Capture-Western Homo sapiens
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