Gene description for RAPGEF3
Gene name	Rap guanine nucleotide exchange factor (GEF) 3
Gene symbol	RAPGEF3
Other names/aliases	CAMP-GEFI EPAC EPAC1 HSU79275 bcm910
Species	Homo sapiens
Database cross references - RAPGEF3
ExoCarta	ExoCarta_10411
Entrez Gene	10411
HGNC	16629
MIM	606057
UniProt	O95398
RAPGEF3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692
Urine	19056867

Gene ontology annotations for RAPGEF3

Molecular Function     Rap guanyl-nucleotide exchange factor activity GO:0017034 IMP     cAMP binding GO:0030552 IEA     cAMP-dependent protein kinase regulator activity GO:0008603 IEA     guanyl-nucleotide exchange factor activity GO:0005085 TAS     protein binding GO:0005515 IPI Biological Process     positive regulation of syncytium formation by plasma membrane fusion GO:0060143 IMP     regulation of actin cytoskeleton reorganization GO:2000249 IMP     regulation of histone H3-K9 acetylation GO:2000615 IMP     negative regulation of syncytium formation by plasma membrane fusion GO:0034242 IMP     cellular response to cAMP GO:0071320 IDA     positive regulation of protein export from nucleus GO:0046827 IDA     cAMP-mediated signaling GO:0019933 NAS     positive regulation of stress fiber assembly GO:0051496 IMP     signal transduction GO:0007165 TAS     cell proliferation GO:0008283 TAS     small molecule metabolic process GO:0044281 TAS     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     regulation of insulin secretion GO:0050796 TAS     energy reserve metabolic process GO:0006112 TAS     positive regulation of cAMP catabolic process GO:0030822 NAS     Rap protein signal transduction GO:0032486 IMP     angiogenesis GO:0001525 IEA     positive regulation of GTPase activity GO:0043547 IMP     regulation of protein kinase activity GO:0045859 IEA     positive regulation of protein acetylation GO:1901985 IMP     positive regulation of angiogenesis GO:0045766 IMP     platelet activation GO:0030168 TAS     blood coagulation GO:0007596 TAS     establishment of endothelial barrier GO:0061028 IMP Subcellular Localization     membrane GO:0016020 TAS     endomembrane system GO:0012505 IEA     plasma membrane GO:0005886 TAS     cAMP-dependent protein kinase complex GO:0005952 IEA     extracellular exosome GO:0070062 IDA