Gene description for VCAM1
Gene name vascular cell adhesion molecule 1
Gene symbol VCAM1
Other names/aliases CD106
INCAM-100
Species Homo sapiens
 Database cross references - VCAM1
ExoCarta ExoCarta_7412
Vesiclepedia VP_7412
Entrez Gene 7412
HGNC 12663
MIM 192225
UniProt P19320  
 VCAM1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VCAM1
Molecular Function
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 IDA
    integrin binding GO:0005178 IMP
    primary methylamine oxidase activity GO:0008131 IDA
    cell adhesion molecule binding GO:0050839 IDA
    cell adhesion molecule binding GO:0050839 IPI
    cell adhesion mediator activity GO:0098631 IDA
Biological Process
    response to hypoxia GO:0001666 IEA
    chronic inflammatory response GO:0002544 IEA
    inflammatory response GO:0006954 IDA
    cell adhesion GO:0007155 IBA
    cell adhesion GO:0007155 IDA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA
    leukocyte cell-cell adhesion GO:0007159 IDA
    cell-matrix adhesion GO:0007160 IDA
    response to nutrient GO:0007584 IEA
    amine metabolic process GO:0009308 IDA
    response to zinc ion GO:0010043 IEA
    response to ionizing radiation GO:0010212 IEA
    membrane to membrane docking GO:0022614 IEP
    B cell differentiation GO:0030183 IC
    response to lipopolysaccharide GO:0032496 IEA
    cell-cell adhesion mediated by integrin GO:0033631 IGI
    heterotypic cell-cell adhesion GO:0034113 IGI
    response to nicotine GO:0035094 IEA
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IEA
    positive regulation of T cell proliferation GO:0042102 IDA
    response to ethanol GO:0045471 IEA
    leukocyte tethering or rolling GO:0050901 IDA
    leukocyte tethering or rolling GO:0050901 IEP
    cell chemotaxis GO:0060326 IEA
    innervation GO:0060384 IEA
    cardiac neuron differentiation GO:0060945 IEA
    cellular response to tumor necrosis factor GO:0071356 IEA
    cellular response to amyloid-beta GO:1904646 IGI
Subcellular Localization
    podosome GO:0002102 IDA
    extracellular space GO:0005615 IDA
    early endosome GO:0005769 IDA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 TAS
    microvillus GO:0005902 IDA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    filopodium GO:0030175 IDA
    sarcolemma GO:0042383 IEA
    apical part of cell GO:0045177 IDA
    extracellular exosome GO:0070062 HDA
    alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex GO:0071065 IDA
 Experiment description of studies that identified VCAM1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VCAM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-MS Homo sapiens
2 EIF3A 8661
Affinity Capture-MS Homo sapiens
3 HIST1H4K 8362
Affinity Capture-MS Homo sapiens
4 SEMA4D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 KRT1 3848
Affinity Capture-MS Homo sapiens
6 STAT5B 6777
Affinity Capture-MS Homo sapiens
7 ZFAND2B  
Affinity Capture-Western Homo sapiens
8 LDHB 3945
Affinity Capture-MS Homo sapiens
9 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
10 DDX17 10521
Affinity Capture-MS Homo sapiens
11 TUBB8 347688
Affinity Capture-MS Homo sapiens
12 SLC2A1 6513
Affinity Capture-MS Homo sapiens
13 TOP1 7150
Affinity Capture-MS Homo sapiens
14 UBC 7316
Affinity Capture-MS Homo sapiens
15 CSE1L 1434
Affinity Capture-MS Homo sapiens
16 NHP2L1 4809
Affinity Capture-MS Homo sapiens
17 KPNA2 3838
Affinity Capture-MS Homo sapiens
18 GCN1L1 10985
Affinity Capture-MS Homo sapiens
19 VASP 7408
Affinity Capture-MS Homo sapiens
20 DECR1 1666
Affinity Capture-MS Homo sapiens
21 SNRNP70 6625
Affinity Capture-MS Homo sapiens
22 DARS 1615
Affinity Capture-MS Homo sapiens
23 AP2A1 160
Affinity Capture-MS Homo sapiens
24 STOM 2040
Affinity Capture-MS Homo sapiens
25 CPSF7 79869
Affinity Capture-MS Homo sapiens
26 PSMB6 5694
Affinity Capture-MS Homo sapiens
27 RPS9 6203
Affinity Capture-MS Homo sapiens
28 EIF3E 3646
Affinity Capture-MS Homo sapiens
29 BCS1L 617
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 RPS11 6205
Affinity Capture-MS Homo sapiens
31 TFRC 7037
Affinity Capture-MS Homo sapiens
32 MSN 4478
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
33 RBM14 10432
Affinity Capture-MS Homo sapiens
34 MYL6 4637
Affinity Capture-MS Homo sapiens
35 ATP1A3 478
Affinity Capture-MS Homo sapiens
36 RBMX 27316
Affinity Capture-MS Homo sapiens
37 HSPA9 3313
Affinity Capture-MS Homo sapiens
38 ZYX 7791
Affinity Capture-MS Homo sapiens
39 KRT19 3880
Affinity Capture-MS Homo sapiens
40 TCP1 6950
Affinity Capture-MS Homo sapiens
41 CAPZA1 829
Affinity Capture-MS Homo sapiens
42 ITGAD  
Reconstituted Complex Homo sapiens
43 MAPRE1 22919
Affinity Capture-MS Homo sapiens
44 TUFM 7284
Affinity Capture-MS Homo sapiens
45 PPIH 10465
Affinity Capture-MS Homo sapiens
46 PABPC1 26986
Affinity Capture-MS Homo sapiens
47 PSMD2 5708
Affinity Capture-MS Homo sapiens
48 MYH9 4627
Affinity Capture-MS Homo sapiens
49 ACTN4 81
Affinity Capture-MS Homo sapiens
50 KRT9 3857
Affinity Capture-MS Homo sapiens
51 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
52 ENO1 2023
Affinity Capture-MS Homo sapiens
53 CAPN1 823
Affinity Capture-MS Homo sapiens
54 DDX39B 7919
Affinity Capture-MS Homo sapiens
55 PICALM 8301
Affinity Capture-MS Homo sapiens
56 VDAC2 7417
Affinity Capture-MS Homo sapiens
57 GTPBP4 23560
Affinity Capture-MS Homo sapiens
58 CACYBP 27101
Affinity Capture-MS Homo sapiens
59 VCP 7415
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
60 CNBP 7555
Affinity Capture-MS Homo sapiens
61 HIST1H2AD 3013
Affinity Capture-MS Homo sapiens
62 RPS19 6223
Affinity Capture-MS Homo sapiens
63 VAMP8 8673
Affinity Capture-MS Homo sapiens
64 LMNB1 4001
Affinity Capture-MS Homo sapiens
65 TYMS 7298
Affinity Capture-MS Homo sapiens
66 HSPE1 3336
Affinity Capture-MS Homo sapiens
67 ANXA1 301
Affinity Capture-MS Homo sapiens
68 YWHAZ 7534
Affinity Capture-MS Homo sapiens
69 EEF1B2 1933
Affinity Capture-MS Homo sapiens
70 STRAP 11171
Affinity Capture-MS Homo sapiens
71 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 PRMT5 10419
Affinity Capture-MS Homo sapiens
73 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
74 IST1 9798
Affinity Capture-MS Homo sapiens
75 HSPA1A 3303
Affinity Capture-MS Homo sapiens
76 PSMC5 5705
Affinity Capture-Western Homo sapiens
77 STMN1 3925
Affinity Capture-MS Homo sapiens
78 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
79 HEATR1 55127
Affinity Capture-MS Homo sapiens
80 DDX1 1653
Affinity Capture-MS Homo sapiens
81 PRKDC 5591
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 RPS16 6217
Affinity Capture-MS Homo sapiens
83 PSMB2 5690
Affinity Capture-MS Homo sapiens
84 ARPC3 10094
Affinity Capture-MS Homo sapiens
85 NUDT21 11051
Affinity Capture-MS Homo sapiens
86 RPS27A 6233
Affinity Capture-MS Homo sapiens
87 FASN 2194
Affinity Capture-MS Homo sapiens
88 TIA1 7072
Affinity Capture-MS Homo sapiens
89 GRB2 2885
Affinity Capture-MS Homo sapiens
90 IARS 3376
Affinity Capture-MS Homo sapiens
91 PLEC 5339
Affinity Capture-MS Homo sapiens
92 MACF1 23499
Affinity Capture-MS Homo sapiens
93 EIF3I 8668
Affinity Capture-MS Homo sapiens
94 RUVBL2 10856
Affinity Capture-MS Homo sapiens
95 PCMT1 5110
Affinity Capture-MS Homo sapiens
96 SRSF9 8683
Affinity Capture-MS Homo sapiens
97 PTBP1 5725
Affinity Capture-MS Homo sapiens
98 APRT 353
Affinity Capture-MS Homo sapiens
99 CAPZB 832
Affinity Capture-MS Homo sapiens
100 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
101 TARS 6897
Affinity Capture-MS Homo sapiens
102 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
103 XPO5 57510
Affinity Capture-MS Homo sapiens
104 DDX3X 1654
Affinity Capture-MS Homo sapiens
105 HIST1H4L 8368
Affinity Capture-MS Homo sapiens
106 RPS24 6229
Affinity Capture-MS Homo sapiens
107 GAPDH 2597
Affinity Capture-MS Homo sapiens
108 ALYREF 10189
Affinity Capture-MS Homo sapiens
109 PSMA5 5686
Affinity Capture-MS Homo sapiens
110 PSMA7 5688
Affinity Capture-MS Homo sapiens
111 HIST1H4J 8363
Affinity Capture-MS Homo sapiens
112 ACO2 50
Affinity Capture-MS Homo sapiens
113 RAB5C 5878
Affinity Capture-MS Homo sapiens
114 ANXA2 302
Affinity Capture-MS Homo sapiens
115 SNRPA1 6627
Affinity Capture-MS Homo sapiens
116 HSPA1B 3304
Affinity Capture-MS Homo sapiens
117 PSMD3 5709
Affinity Capture-MS Homo sapiens
118 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
119 PSMA6 5687
Affinity Capture-MS Homo sapiens
120 LDHA 3939
Affinity Capture-MS Homo sapiens
121 MCM3 4172
Affinity Capture-MS Homo sapiens
122 VARS 7407
Affinity Capture-MS Homo sapiens
123 NUP188 23511
Affinity Capture-MS Homo sapiens
124 TARDBP 23435
Affinity Capture-MS Homo sapiens
125 YARS 8565
Affinity Capture-MS Homo sapiens
126 PCBP2 5094
Affinity Capture-MS Homo sapiens
127 LGALS1 3956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 RPL14 9045
Affinity Capture-MS Homo sapiens
129 EIF4A1 1973
Affinity Capture-MS Homo sapiens
130 CAPNS1 826
Affinity Capture-MS Homo sapiens
131 COPA 1314
Affinity Capture-MS Homo sapiens
132 YTHDF2 51441
Affinity Capture-MS Homo sapiens
133 RPS18 6222
Affinity Capture-MS Homo sapiens
134 PDCD10 11235
Affinity Capture-MS Homo sapiens
135 FERMT3 83706
Affinity Capture-MS Homo sapiens
136 DIAPH1 1729
Affinity Capture-MS Homo sapiens
137 TUBB 203068
Affinity Capture-MS Homo sapiens
138 TLN1 7094
Affinity Capture-MS Homo sapiens
139 HIST2H3A 333932
Affinity Capture-MS Homo sapiens
140 GNB1 2782
Affinity Capture-MS Homo sapiens
141 MRPS23 51649
Affinity Capture-MS Homo sapiens
142 NPM1 4869
Affinity Capture-MS Homo sapiens
143 SYK 6850
Affinity Capture-MS Homo sapiens
144 PRDX2 7001
Affinity Capture-MS Homo sapiens
145 BOLA2 552900
Affinity Capture-MS Homo sapiens
146 STIP1 10963
Affinity Capture-MS Homo sapiens
147 PHB 5245
Affinity Capture-MS Homo sapiens
148 DDX6 1656
Affinity Capture-MS Homo sapiens
149 FBL 2091
Affinity Capture-MS Homo sapiens
150 SDCBP 6386
Affinity Capture-MS Homo sapiens
151 RAVER1 125950
Affinity Capture-MS Homo sapiens
152 BCKDHB 594
Affinity Capture-MS Homo sapiens
153 ATAD3A 55210
Affinity Capture-MS Homo sapiens
154 YWHAB 7529
Affinity Capture-MS Homo sapiens
155 CCT2 10576
Affinity Capture-MS Homo sapiens
156 PFN1 5216
Affinity Capture-MS Homo sapiens
157 SDK2 54549
Affinity Capture-MS Homo sapiens
158 HNRNPA0 10949
Affinity Capture-MS Homo sapiens
159 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
160 DDX21 9188
Affinity Capture-MS Homo sapiens
161 RPL4 6124
Affinity Capture-MS Homo sapiens
162 HIST1H4E 8367
Affinity Capture-MS Homo sapiens
163 DRG1 4733
Affinity Capture-MS Homo sapiens
164 UBAP2L 9898
Affinity Capture-MS Homo sapiens
165 BAG6 7917
Affinity Capture-Western Homo sapiens
166 NTPCR 84284
Affinity Capture-MS Homo sapiens
167 SNRNP200 23020
Affinity Capture-MS Homo sapiens
168 RPL35 11224
Affinity Capture-MS Homo sapiens
169 RAP1B 5908
Affinity Capture-MS Homo sapiens
170 SNRPD1 6632
Affinity Capture-MS Homo sapiens
171 PPP2CA 5515
Affinity Capture-MS Homo sapiens
172 NCL 4691
Affinity Capture-MS Homo sapiens
173 HNRNPL 3191
Affinity Capture-MS Homo sapiens
174 RPLP0 6175
Affinity Capture-MS Homo sapiens
175 GMPS 8833
Affinity Capture-MS Homo sapiens
176 HBA1 3039
Affinity Capture-MS Homo sapiens
177 ULBP3 79465
Affinity Capture-MS Homo sapiens
178 STON2 85439
Affinity Capture-MS Homo sapiens
179 HNRNPD 3184
Affinity Capture-MS Homo sapiens
180 PTPN11 5781
Affinity Capture-MS Homo sapiens
181 PSMA3 5684
Affinity Capture-MS Homo sapiens
182 KHSRP 8570
Affinity Capture-MS Homo sapiens
183 CCL17  
Reconstituted Complex Homo sapiens
184 RPS2 6187
Affinity Capture-MS Homo sapiens
185 XPO1 7514
Affinity Capture-MS Homo sapiens
186 EIF6 3692
Affinity Capture-MS Homo sapiens
187 CLTA 1211
Affinity Capture-MS Homo sapiens
188 TUBB4B 10383
Affinity Capture-MS Homo sapiens
189 FUS 2521
Affinity Capture-MS Homo sapiens
190 LARS 51520
Affinity Capture-MS Homo sapiens
191 EFTUD2 9343
Affinity Capture-MS Homo sapiens
192 RPS27 6232
Affinity Capture-MS Homo sapiens
193 SLC7A3  
Affinity Capture-MS Homo sapiens
194 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
195 ATP2A1 487
Affinity Capture-MS Homo sapiens
196 MYL4 4635
Affinity Capture-MS Homo sapiens
197 HIST1H4F 8361
Affinity Capture-MS Homo sapiens
198 LMNA 4000
Affinity Capture-MS Homo sapiens
199 RAC2 5880
Affinity Capture-MS Homo sapiens
200 PSMB1 5689
Affinity Capture-MS Homo sapiens
201 EEF1A1 1915
Affinity Capture-MS Homo sapiens
202 KRT18 3875
Affinity Capture-MS Homo sapiens
203 SFPQ 6421
Affinity Capture-MS Homo sapiens
204 PARP1 142
Affinity Capture-MS Homo sapiens
205 ILF3 3609
Affinity Capture-MS Homo sapiens
206 PDCD6IP 10015
Affinity Capture-MS Homo sapiens
207 VIM 7431
Affinity Capture-MS Homo sapiens
208 EZR 7430
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
209 RPS12 6206
Affinity Capture-MS Homo sapiens
210 RPS4X 6191
Affinity Capture-MS Homo sapiens
211 FKBP4 2288
Affinity Capture-MS Homo sapiens
212 MDH2 4191
Affinity Capture-MS Homo sapiens
213 BUB3 9184
Affinity Capture-MS Homo sapiens
214 RPS5 6193
Affinity Capture-MS Homo sapiens
215 CDK1 983
Affinity Capture-MS Homo sapiens
216 TAGLN2 8407
Affinity Capture-MS Homo sapiens
217 EEF1D 1936
Affinity Capture-MS Homo sapiens
218 HBG1 3047
Affinity Capture-MS Homo sapiens
219 RPL7A 6130
Affinity Capture-MS Homo sapiens
220 PRDX1 5052
Affinity Capture-MS Homo sapiens
221 ARF1 375
Affinity Capture-MS Homo sapiens
222 GLRX3 10539
Affinity Capture-MS Homo sapiens
223 ATP5C1 509
Affinity Capture-MS Homo sapiens
224 HBZ  
Affinity Capture-MS Homo sapiens
225 RALY 22913
Affinity Capture-MS Homo sapiens
226 AP2S1 1175
Affinity Capture-MS Homo sapiens
227 MCM7 4176
Affinity Capture-MS Homo sapiens
228 HNRNPC 3183
Affinity Capture-MS Homo sapiens
229 GSTP1 2950
Affinity Capture-MS Homo sapiens
230 EEF1G 1937
Affinity Capture-MS Homo sapiens
231 NDUFS1 4719
Affinity Capture-MS Homo sapiens
232 NAPA 8775
Affinity Capture-MS Homo sapiens
233 YWHAE 7531