Gene description for SF3B6
Gene name splicing factor 3b, subunit 6, 14kDa
Gene symbol SF3B6
Other names/aliases CGI-110
HSPC175
Ht006
P14
SAP14
SAP14a
SF3B14
SF3B14a
Species Homo sapiens
 Database cross references - SF3B6
ExoCarta ExoCarta_51639
Entrez Gene 51639
HGNC 30096
MIM 607835
UniProt Q9Y3B4  
 SF3B6 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SF3B6
Molecular Function
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    RNA splicing GO:0008380 TAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    gene expression GO:0010467 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    U12-type spliceosomal complex GO:0005689 IDA
 Experiment description of studies that identified SF3B6 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SF3B6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SF3B4 10262
Invitro Homo sapiens
2 SF3B1 23451
Reconstituted Complex Homo sapiens
3 PHF5A 84844
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which SF3B6 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway TAS Reactome
mRNA Splicing - Minor Pathway TAS Reactome





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