Gene description for BCS1L
Gene name BC1 (ubiquinol-cytochrome c reductase) synthesis-like
Gene symbol BCS1L
Other names/aliases BCS
BCS1
BJS
FLNMS
GRACILE
Hs.6719
MC3DN1
PTD
h-BCS
Species Homo sapiens
 Database cross references - BCS1L
ExoCarta ExoCarta_617
Vesiclepedia VP_617
Entrez Gene 617
HGNC 1020
MIM 603647
UniProt Q9Y276  
 BCS1L identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BCS1L
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
Biological Process
    mitochondrion organization GO:0007005 IMP
    protein insertion into mitochondrial inner membrane from matrix GO:0032979 IBA
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
    mitochondrial cytochrome c oxidase assembly GO:0033617 IMP
    mitochondrial respiratory chain complex III assembly GO:0034551 IBA
    mitochondrial respiratory chain complex III assembly GO:0034551 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
    respiratory chain complex III GO:0045275 TAS
 Experiment description of studies that identified BCS1L in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BCS1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 SLIRP 81892
Proximity Label-MS Homo sapiens
3 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
4 COQ9  
Affinity Capture-MS Homo sapiens
5 MBLAC2 153364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 VAPA 9218
Co-fractionation Homo sapiens
7 TMEFF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TRUB2  
Proximity Label-MS Homo sapiens
9 MTG2  
Proximity Label-MS Homo sapiens
10 MDFI  
Affinity Capture-MS Homo sapiens
11 CHCHD1  
Proximity Label-MS Homo sapiens
12 MRPL10 124995
Co-fractionation Homo sapiens
13 RPUSD4 84881
Proximity Label-MS Homo sapiens
14 DNAJC15  
Proximity Label-MS Homo sapiens
15 MTRF1  
Proximity Label-MS Homo sapiens
16 GFM2 84340
Proximity Label-MS Homo sapiens
17 CCDC90B  
Proximity Label-MS Homo sapiens
18 LRPPRC 10128
Proximity Label-MS Homo sapiens
19 VPS26A 9559
Affinity Capture-MS Homo sapiens
20 CRYZ 1429
Proximity Label-MS Homo sapiens
21 PMPCA 23203
Proximity Label-MS Homo sapiens
22 DDX24 57062
Two-hybrid Homo sapiens
23 C8orf82  
Proximity Label-MS Homo sapiens
24 C4orf3  
Affinity Capture-MS Homo sapiens
25 HINT2 84681
Proximity Label-MS Homo sapiens
26 MRPS26 64949
Proximity Label-MS Homo sapiens
27 EXD2  
Proximity Label-MS Homo sapiens
28 VCAM1 7412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 EMB 133418
Affinity Capture-MS Homo sapiens
30 PMPCB 9512
Proximity Label-MS Homo sapiens
31 TACO1  
Proximity Label-MS Homo sapiens
32 FASTKD2  
Proximity Label-MS Homo sapiens
33 VWA8 23078
Proximity Label-MS Homo sapiens
34 MTERF3  
Proximity Label-MS Homo sapiens
35 IMPDH1 3614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MDH2 4191
Proximity Label-MS Homo sapiens
37 UCKL1 54963
Co-fractionation Homo sapiens
38 C6orf203  
Proximity Label-MS Homo sapiens
39 FASTKD5  
Proximity Label-MS Homo sapiens
40 PARK2  
Affinity Capture-MS Homo sapiens
41 TUFM 7284
Proximity Label-MS Homo sapiens
42 HSCB 150274
Proximity Label-MS Homo sapiens
43 CCDC109B 55013
Proximity Label-MS Homo sapiens
44 DNAJA1 3301
Two-hybrid Homo sapiens
45 TBRG4 9238
Proximity Label-MS Homo sapiens
46 MTFMT  
Proximity Label-MS Homo sapiens
47 MRPL11 65003
Proximity Label-MS Homo sapiens
48 MTRF1L  
Proximity Label-MS Homo sapiens
49 DNAJC30  
Affinity Capture-MS Homo sapiens
50 GSX1  
Affinity Capture-MS Homo sapiens
51 MRRF  
Proximity Label-MS Homo sapiens
52 Myh9 17886
Affinity Capture-MS Mus musculus
53 AIFM1 9131
Co-fractionation Homo sapiens
54 MRPS12  
Proximity Label-MS Homo sapiens
55 MTIF2 4528
Proximity Label-MS Homo sapiens
56 C9orf78 51759
Affinity Capture-MS Homo sapiens
57 MTIF3  
Proximity Label-MS Homo sapiens
58 MATN4 8785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 CRELD1 78987
Affinity Capture-MS Homo sapiens
60 TMEM128  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MX1 4599
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 FUS 2521
Affinity Capture-MS Homo sapiens
63 C12orf65  
Proximity Label-MS Homo sapiens
64 MTG1  
Proximity Label-MS Homo sapiens
65 RPA3 6119
Proximity Label-MS Homo sapiens
66 ACAD9 28976
Proximity Label-MS Homo sapiens
67 METTL15  
Proximity Label-MS Homo sapiens
68 BRD3 8019
Affinity Capture-MS Homo sapiens
69 MCUR1 63933
Proximity Label-MS Homo sapiens
70 SAYSD1  
Affinity Capture-MS Homo sapiens
71 MAGEA8  
Affinity Capture-MS Homo sapiens
72 SLC2A12 154091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CLPP 8192
Proximity Label-MS Homo sapiens
74 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
75 NME6  
Affinity Capture-MS Homo sapiens
76 NRP1 8829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 TSFM 10102
Proximity Label-MS Homo sapiens
78 AUH 549
Proximity Label-MS Homo sapiens
79 ICT1 3396
Proximity Label-MS Homo sapiens
80 LONP1 9361
Proximity Label-MS Homo sapiens
81 Rbm8a  
Affinity Capture-MS Mus musculus
82 PDHA1 5160
Proximity Label-MS Homo sapiens
83 LITAF 9516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 COX8A  
Proximity Label-MS Homo sapiens
86 C21orf33  
Proximity Label-MS Homo sapiens
87 SSBP1 6742
Proximity Label-MS Homo sapiens
88 CD80 941
Affinity Capture-MS Homo sapiens
89 RBFOX2 23543
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 GFM1 85476
Proximity Label-MS Homo sapiens
91 ACYP2  
Affinity Capture-MS Homo sapiens
92 RPUSD3  
Proximity Label-MS Homo sapiens
93 C1QBP 708
Proximity Label-MS Homo sapiens
94 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
95 METTL17  
Proximity Label-MS Homo sapiens
96 ARSF 416
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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