Gene description for CCL22
Gene name chemokine (C-C motif) ligand 22
Gene symbol CCL22
Other names/aliases A-152E5.1
ABCD-1
DC/B-CK
MDC
SCYA22
STCP-1
Species Homo sapiens
 Database cross references - CCL22
ExoCarta ExoCarta_6367
Entrez Gene 6367
HGNC 10621
MIM 602957
UniProt O00626  
 CCL22 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CCL22
Molecular Function
    chemokine activity GO:0008009 IEA
Biological Process
    inflammatory response GO:0006954 IEA
    response to virus GO:0009615 TAS
    cell chemotaxis GO:0060326 IEA
    cell-cell signaling GO:0007267 TAS
    signal transduction GO:0007165 TAS
    chemotaxis GO:0006935 TAS
    immune response GO:0006955 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified CCL22 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CCL22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCR4 1233
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
2 VCAM1  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CCL22 is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines TAS Reactome





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