Gene description for PF4V1
Gene name platelet factor 4 variant 1
Gene symbol PF4V1
Other names/aliases CXCL4L1
CXCL4V1
PF4-ALT
PF4A
SCYB4V1
Species Homo sapiens
 Database cross references - PF4V1
ExoCarta ExoCarta_5197
Vesiclepedia VP_5197
Entrez Gene 5197
HGNC 8862
MIM 173461
UniProt P10720  
 PF4V1 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for PF4V1
Molecular Function
    chemokine activity GO:0008009 IBA
    heparin binding GO:0008201 IBA
    CXCR chemokine receptor binding GO:0045236 IBA
Biological Process
    immune response GO:0006955 IBA
    chemokine-mediated signaling pathway GO:0070098 IBA
    inflammatory response GO:0006954 IBA
    G-protein coupled receptor signaling pathway GO:0007186 IBA
    regulation of cell proliferation GO:0042127 IBA
    response to lipopolysaccharide GO:0032496 IBA
    positive regulation of leukocyte chemotaxis GO:0002690 IBA
    cell chemotaxis GO:0060326 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified PF4V1 in exosomes
1
Experiment ID 494
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PF4V1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PF4V1 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome
Common Pathway of Fibrin Clot Formation TAS Reactome





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