Gene description for DPP8
Gene name dipeptidyl-peptidase 8
Gene symbol DPP8
Other names/aliases DP8
DPRP1
MSTP141
Species Homo sapiens
 Database cross references - DPP8
ExoCarta ExoCarta_54878
Vesiclepedia VP_54878
Entrez Gene 54878
HGNC 16490
MIM 606819
UniProt Q6V1X1  
 DPP8 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DPP8
Molecular Function
    aminopeptidase activity GO:0004177 IEA
    protein binding GO:0005515 IPI
    serine-type peptidase activity GO:0008236 IEA
    dipeptidyl-peptidase activity GO:0008239 IBA
    dipeptidyl-peptidase activity GO:0008239 IDA
    dipeptidyl-peptidase activity GO:0008239 NAS
Biological Process
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 NAS
    apoptotic process GO:0006915 IEA
    immune response GO:0006955 TAS
    negative regulation of programmed cell death GO:0043069 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 NAS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified DPP8 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DPP8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 P3H1 64175
Co-fractionation Homo sapiens
2 ZNF282  
Affinity Capture-MS Homo sapiens
3 SFN 2810
Co-fractionation Homo sapiens
4 ACTN4 81
Co-fractionation Homo sapiens
5 CCL22 6367
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TSNAXIP1 55815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DPP9 91039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 AMD1  
Affinity Capture-MS Homo sapiens
9 WDR4 10785
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
10 IL17A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 UBXN4 23190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CIAO1 9391
Affinity Capture-MS Homo sapiens
13 FBXO10  
Affinity Capture-MS Homo sapiens
14 DOK3 79930
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 UBXN7 26043
Co-fractionation Homo sapiens
16 CALU 813
Co-fractionation Homo sapiens
17 SRP9 6726
Co-fractionation Homo sapiens
18 PFDN1 5201
Co-fractionation Homo sapiens
19 LGALS1 3956
Affinity Capture-MS Homo sapiens
20 DMWD  
Affinity Capture-MS Homo sapiens
21 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
22 FUBP3 8939
Co-fractionation Homo sapiens
23 ARHGEF16 27237
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SHMT2 6472
Affinity Capture-MS Homo sapiens
25 CXorf57  
Affinity Capture-MS Homo sapiens
26 KRBA1  
Affinity Capture-MS Homo sapiens
27 ATF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 UBB 7314
Affinity Capture-MS Homo sapiens
29 SNRPB 6628
Affinity Capture-MS Homo sapiens
30 EPS8L1 54869
Affinity Capture-MS Homo sapiens
31 RELT  
Affinity Capture-MS Homo sapiens
32 ESRRA  
Co-fractionation Homo sapiens
33 NLRP1  
Affinity Capture-MS Homo sapiens
34 RIN1 9610
Affinity Capture-MS Homo sapiens
35 ARMC9 80210
Co-fractionation Homo sapiens
36 DHPS 1725
Co-fractionation Homo sapiens
37 WDR90  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SNRPN 6638
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 COA7  
Affinity Capture-MS Homo sapiens
40 CD44 960
Co-fractionation Homo sapiens
41 AARS 16
Co-fractionation Homo sapiens
42 SRP14 6727
Co-fractionation Homo sapiens
43 IRAK3 11213
Affinity Capture-MS Homo sapiens
44 IDO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PIGQ  
Affinity Capture-MS Homo sapiens
46 ICAM4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DPP8 is involved
No pathways found





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