Gene description for ITGA8
Gene name integrin, alpha 8
Gene symbol ITGA8
Other names/aliases -
Species Homo sapiens
 Database cross references - ITGA8
ExoCarta ExoCarta_8516
Vesiclepedia VP_8516
Entrez Gene 8516
HGNC 6144
MIM 604063
UniProt P53708  
 ITGA8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ITGA8
Molecular Function
    metal ion binding GO:0046872 IEA
Biological Process
    extracellular matrix organization GO:0030198 TAS
    inner ear morphogenesis GO:0042472 IEA
    memory GO:0007613 IEA
    mesodermal cell differentiation GO:0048333 IEP
    metanephros development GO:0001656 IEA
    cell-matrix adhesion GO:0007160 NAS
    substrate adhesion-dependent cell spreading GO:0034446 IMP
    establishment of protein localization GO:0045184 IEA
    kidney development GO:0001822 IMP
    smooth muscle tissue development GO:0048745 IEA
    single organismal cell-cell adhesion GO:0016337 NAS
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IEA
    integrin-mediated signaling pathway GO:0007229 IEA
    brain development GO:0007420 IEA
    cell projection organization GO:0030030 IEA
    positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation GO:2000721 IEA
Subcellular Localization
    integrin complex GO:0008305 TAS
    dendritic spine membrane GO:0032591 IEA
    perikaryon GO:0043204 IEA
    plasma membrane GO:0005886 TAS
    endoplasmic reticulum GO:0005783 IDA
    apical part of cell GO:0045177 IEA
    cell surface GO:0009986 IDA
    integrin alpha8-beta1 complex GO:0034678 TAS
    focal adhesion GO:0005925 IDA
    postsynaptic density GO:0014069 IEA
 Experiment description of studies that identified ITGA8 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ITGA8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VTN 7448
Invitro Homo sapiens
2 FN1 2335
Invitro Homo sapiens
3 NPNT 255743
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 ITGB1 3688
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ITGA8 is involved
PathwayEvidenceSource
ECM proteoglycans TAS Reactome
Integrin cell surface interactions TAS Reactome
Molecules associated with elastic fibres TAS Reactome





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