Gene description for ITGA8
Gene name integrin, alpha 8
Gene symbol ITGA8
Other names/aliases -
Species Homo sapiens
 Database cross references - ITGA8
ExoCarta ExoCarta_8516
Vesiclepedia VP_8516
Entrez Gene 8516
HGNC 6144
MIM 604063
UniProt P53708  
 ITGA8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ITGA8
Molecular Function
    integrin binding GO:0005178 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    metanephros development GO:0001656 IEA
    kidney development GO:0001822 IMP
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 IMP
    cell-matrix adhesion GO:0007160 NAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    integrin-mediated signaling pathway GO:0007229 IBA
    nervous system development GO:0007399 IEA
    memory GO:0007613 IEA
    cell projection organization GO:0030030 IEA
    extracellular matrix organization GO:0030198 IEA
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IEA
    cell adhesion mediated by integrin GO:0033627 IBA
    substrate adhesion-dependent cell spreading GO:0034446 IMP
    inner ear morphogenesis GO:0042472 IEA
    establishment of protein localization GO:0045184 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    mesodermal cell differentiation GO:0048333 IEP
    smooth muscle tissue development GO:0048745 IEA
    smooth muscle cell differentiation GO:0051145 IEA
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 NAS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 HDA
    integrin complex GO:0008305 IBA
    integrin complex GO:0008305 TAS
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 IDA
    dendritic spine membrane GO:0032591 IEA
    integrin alpha8-beta1 complex GO:0034678 TAS
    perikaryon GO:0043204 IEA
    apical part of cell GO:0045177 IEA
    postsynaptic density membrane GO:0098839 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified ITGA8 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ITGA8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 NPNT 255743
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 BST1 683
Affinity Capture-MS Homo sapiens
4 ZDHHC18 84243
Affinity Capture-MS Homo sapiens
5 GPIHBP1  
Affinity Capture-MS Homo sapiens
6 PICK1  
Affinity Capture-MS Homo sapiens
7 CCL22 6367
Affinity Capture-MS Homo sapiens
8 DECR2 26063
Affinity Capture-MS Homo sapiens
9 ART3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LGALS1 3956
Affinity Capture-MS Homo sapiens
11 CEACAM8 1088
Affinity Capture-MS Homo sapiens
12 TRAPPC5 126003
Affinity Capture-MS Homo sapiens
13 HDGF 3068
Cross-Linking-MS (XL-MS) Homo sapiens
14 SIAE 54414
Affinity Capture-MS Homo sapiens
15 CLDND1 56650
Affinity Capture-MS Homo sapiens
16 ZNRF3  
Affinity Capture-MS Homo sapiens
17 DHRS7 51635
Affinity Capture-MS Homo sapiens
18 CALR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DSC3 1825
Affinity Capture-MS Homo sapiens
20 HIGD1A 25994
Affinity Capture-MS Homo sapiens
21 C7orf34  
Affinity Capture-MS Homo sapiens
22 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SCGB1D4  
Affinity Capture-MS Homo sapiens
24 DEFB109P1B  
Affinity Capture-MS Homo sapiens
25 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
26 Pparg 19016
Affinity Capture-MS Mus musculus
27 PDGFRA 5156
Affinity Capture-MS Homo sapiens
28 PNLIPRP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ITIH2 3698
Affinity Capture-MS Homo sapiens
30 FBXO2 26232
Affinity Capture-MS Homo sapiens
31 HOOK3 84376
Affinity Capture-MS Homo sapiens
32 CLU 1191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 LY6G5C  
Affinity Capture-MS Homo sapiens
34 LCTL  
Affinity Capture-MS Homo sapiens
35 NPAP1  
Affinity Capture-MS Homo sapiens
36 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
37 EDDM3A  
Affinity Capture-MS Homo sapiens
38 DEFB136  
Affinity Capture-MS Homo sapiens
39 TMEM25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 SUSD5 26032
Affinity Capture-MS Homo sapiens
41 SUSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 GPRC5C 55890
Affinity Capture-MS Homo sapiens
43 LCN9  
Affinity Capture-MS Homo sapiens
44 GML  
Affinity Capture-MS Homo sapiens
45 PSCA 8000
Affinity Capture-MS Homo sapiens
46 DEFB135  
Affinity Capture-MS Homo sapiens
47 PCDHGA10  
Affinity Capture-MS Homo sapiens
48 NUS1  
Affinity Capture-MS Homo sapiens
49 PTPRK 5796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CD160  
Affinity Capture-MS Homo sapiens
51 LEMD3  
Affinity Capture-MS Homo sapiens
52 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
53 PTCH1  
Affinity Capture-MS Homo sapiens
54 TRAV20  
Affinity Capture-MS Homo sapiens
55 THEM6  
Affinity Capture-MS Homo sapiens
56 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 BTNL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 FAM19A4  
Affinity Capture-MS Homo sapiens
59 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
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